SEM1_MOUSE
ID SEM1_MOUSE Reviewed; 70 AA.
AC P60897; Q13437; Q61067;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=26S proteasome complex subunit SEM1;
DE AltName: Full=26S proteasome complex subunit DSS1;
DE AltName: Full=Deleted in split hand/split foot protein 1 homolog;
DE AltName: Full=Split hand/foot deleted protein 1 homolog;
DE AltName: Full=Split hand/foot malformation type 1 protein homolog;
GN Name=Sem1; Synonyms=Dss1, Shfdg1, Shfm1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8733122; DOI=10.1093/hmg/5.5.571;
RA Crackower M.A., Scherer S.W., Rommens J.M., Hui C.-C., Poorkaj P.,
RA Soder S., Cobben J.M., Hudgins L., Evans J.P., Tsui L.-C.;
RT "Characterization of the split hand/split foot malformation locus SHFM1 at
RT 7q21.3-q22.1 and analysis of a candidate gene for its expression during
RT limb development.";
RL Hum. Mol. Genet. 5:571-579(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the 26S proteasome, a multiprotein complex
CC involved in the ATP-dependent degradation of ubiquitinated proteins.
CC This complex plays a key role in the maintenance of protein homeostasis
CC by removing misfolded or damaged proteins, which could impair cellular
CC functions, and by removing proteins whose functions are no longer
CC required. Therefore, the proteasome participates in numerous cellular
CC processes, including cell cycle progression, apoptosis, or DNA damage
CC repair. Component of the TREX-2 complex (transcription and export
CC complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either
CC centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-
CC competent ribonucleoprotein particles (mRNPs) to the nuclear entrance
CC of the nuclear pore complex (nuclear basket). TREX-2 participates in
CC mRNA export and accurate chromatin positioning in the nucleus by
CC tethering genes to the nuclear periphery. Binds and stabilizes BRCA2
CC and is thus involved in the control of R-loop-associated DNA damage and
CC thus transcription-associated genomic instability. R-loop accumulation
CC increases in SEM1-depleted cells. {ECO:0000250|UniProtKB:P60896}.
CC -!- SUBUNIT: Component of the 19S proteasome regulatory particle complex.
CC The 26S proteasome consists of a 20S core particle (CP) and two 19S
CC regulatory subunits (RP). The regulatory particle is made of a lid
CC composed of 9 subunits including SEM1, a base containing 6 ATPases and
CC few additional components. Belongs to the TREX-2 complex (transcription
CC and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1,
CC and either centrin CETN2 or CETN3. Component of the homologous
CC recombination repair (HR) complex composed of ERCC5/XPG, BRCA2, PALB2,
CC DSS1 and RAD51 (By similarity). Interacts with the C-terminal of BRCA2.
CC {ECO:0000250|UniProtKB:P60896}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P60896}.
CC -!- SIMILARITY: Belongs to the DSS1/SEM1 family. {ECO:0000305}.
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DR EMBL; U41626; AAA91180.1; -; mRNA.
DR EMBL; BC023490; AAH23490.1; -; mRNA.
DR EMBL; BC058117; AAH58117.1; -; mRNA.
DR CCDS; CCDS39422.1; -.
DR RefSeq; NP_033195.1; NM_009169.2.
DR AlphaFoldDB; P60897; -.
DR SMR; P60897; -.
DR BioGRID; 203219; 1.
DR STRING; 10090.ENSMUSP00000040741; -.
DR PhosphoSitePlus; P60897; -.
DR PaxDb; P60897; -.
DR PeptideAtlas; P60897; -.
DR PRIDE; P60897; -.
DR DNASU; 20422; -.
DR Ensembl; ENSMUST00000041111; ENSMUSP00000040741; ENSMUSG00000042541.
DR GeneID; 20422; -.
DR KEGG; mmu:20422; -.
DR UCSC; uc009aws.1; mouse.
DR CTD; 7979; -.
DR MGI; MGI:109238; Sem1.
DR VEuPathDB; HostDB:ENSMUSG00000042541; -.
DR eggNOG; KOG4764; Eukaryota.
DR GeneTree; ENSGT00940000162732; -.
DR HOGENOM; CLU_141774_1_2_1; -.
DR InParanoid; P60897; -.
DR OMA; TLWENNW; -.
DR PhylomeDB; P60897; -.
DR TreeFam; TF314699; -.
DR BioGRID-ORCS; 20422; 27 hits in 113 CRISPR screens.
DR ChiTaRS; Sem1; mouse.
DR PRO; PR:P60897; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; P60897; protein.
DR Bgee; ENSMUSG00000042541; Expressed in urogenital fold and 280 other tissues.
DR ExpressionAtlas; P60897; baseline and differential.
DR Genevisible; P60897; MM.
DR GO; GO:0032039; C:integrator complex; ISO:MGI.
DR GO; GO:0000502; C:proteasome complex; ISS:UniProtKB.
DR GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:InterPro.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:MGI.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR GO; GO:0043248; P:proteasome assembly; IEA:InterPro.
DR InterPro; IPR007834; DSS1_SEM1.
DR PANTHER; PTHR16771; PTHR16771; 1.
DR Pfam; PF05160; DSS1_SEM1; 1.
DR SMART; SM01385; DSS1_SEM1; 1.
PE 3: Inferred from homology;
KW Nucleus; Proteasome; Reference proteome.
FT CHAIN 1..70
FT /note="26S proteasome complex subunit SEM1"
FT /id="PRO_0000122962"
SQ SEQUENCE 70 AA; 8278 MW; 0E0F58D2F3D9F723 CRC64;
MSEKKQPVDL GLLEEDDEFE EFPAEDWAGL DEDEDAHVWE DNWDDDNVED DFSNQLRAEL
EKHGYKMETS
