SEM3B_MOUSE
ID SEM3B_MOUSE Reviewed; 748 AA.
AC Q62177; E9Q9Q1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 25-MAY-2022, entry version 147.
DE RecName: Full=Semaphorin-3B;
DE AltName: Full=Semaphorin-A;
DE Short=Sema A;
DE Flags: Precursor;
GN Name=Sema3b; Synonyms=Sema, Semaa;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=NMRI; TISSUE=Embryo;
RX PubMed=7748561; DOI=10.1016/0896-6273(95)90332-1;
RA Pueschel A.W., Adams R.H., Betz H.;
RT "Murine semaphorin D/collapsin is a member of a diverse gene family and
RT creates domains inhibitory for axonal extension.";
RL Neuron 14:941-948(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Inhibits axonal extension by providing local signals to
CC specify territories inaccessible for growing axons.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed from day 10 in the embryo. Low levels
CC found between days 10-12. Expression peaks on day 13 with moderate
CC levels from then until birth.
CC -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
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DR EMBL; X85990; CAA59982.1; -; mRNA.
DR EMBL; AL672219; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; I48744; I48744.
DR AlphaFoldDB; Q62177; -.
DR SMR; Q62177; -.
DR STRING; 10090.ENSMUSP00000099591; -.
DR GlyGen; Q62177; 2 sites.
DR iPTMnet; Q62177; -.
DR PhosphoSitePlus; Q62177; -.
DR MaxQB; Q62177; -.
DR PaxDb; Q62177; -.
DR PeptideAtlas; Q62177; -.
DR PRIDE; Q62177; -.
DR ProteomicsDB; 256540; -.
DR MGI; MGI:107561; Sema3b.
DR eggNOG; KOG3611; Eukaryota.
DR InParanoid; Q62177; -.
DR ChiTaRS; Sema3b; mouse.
DR PRO; PR:Q62177; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q62177; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045499; F:chemorepellent activity; IBA:GO_Central.
DR GO; GO:0030215; F:semaphorin receptor binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IBA:GO_Central.
DR GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; PTHR11036; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF101912; SSF101912; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Neurogenesis; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..748
FT /note="Semaphorin-3B"
FT /id="PRO_0000032310"
FT DOMAIN 30..512
FT /note="Sema"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DOMAIN 561..659
FT /note="Ig-like C2-type"
FT REGION 708..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..748
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 102..113
FT /evidence="ECO:0000250"
FT DISULFID 131..140
FT /evidence="ECO:0000250"
FT DISULFID 268..379
FT /evidence="ECO:0000250"
FT DISULFID 292..339
FT /evidence="ECO:0000250"
FT DISULFID 515..533
FT /evidence="ECO:0000250"
FT DISULFID 643..709
FT /evidence="ECO:0000250"
FT CONFLICT 8
FT /note="A -> V (in Ref. 1; CAA59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 118
FT /note="K -> R (in Ref. 1; CAA59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 122
FT /note="T -> A (in Ref. 1; CAA59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 132
FT /note="G -> R (in Ref. 1; CAA59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 175..176
FT /note="AA -> PP (in Ref. 1; CAA59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 354..355
FT /note="FA -> LP (in Ref. 1; CAA59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 401
FT /note="A -> G (in Ref. 1; CAA59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 466
FT /note="S -> R (in Ref. 1; CAA59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 501
FT /note="I -> V (in Ref. 1; CAA59982)"
FT /evidence="ECO:0000305"
FT CONFLICT 505
FT /note="S -> A (in Ref. 1; CAA59982)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 748 AA; 82700 MW; E0B4D127F2E75C9E CRC64;
MGRAEAAAMI PGLALLWVAG LGDTAPNLPR LRLSFQELQA RHGVRTFRLE RTCCYEALLV
DEERGRLFVG AENHVASLSL DNISKRAKKL AWPAPVEWRE ECNWAGKDIG TECMNFVKLL
HTYNHTHLLA CGTGAFHPTC ALWRWATAGG THASTGPEKL EDGKGKTPYD PRHRAASVLV
GEELYSGVTA DLMGRDFTIF RSLGQNPSLR TEPHDSRWLN EPKFVKVFWI PESENPDDDK
IYFFFRESAV EAAPAMGRMS VSRVGQICRN DLGGQRSLVN KWTTFLKARL VCSVPGVEGD
THFDQLQDVF LLSSRDRQTP LLYAVFSTSS GVFQGSAVCV YSMNDVRRAF LGPFAHKEGP
THQWVSYQGR VPYPRPGMCP SKTFGTFSST KDFPDDVIQF ARNHPLMYNP VLPMGGRPLF
LQVGAGYTFT QIAADRVAAA DGHYDVLFIG TDVGTVLKVI SVPKGSRPNS EGLLLEELQV
FEDSAAITSM QISSKRQQLY IASRSAVAQI ALHRCTALGR ACAECCLARD PYCAWDGSAC
TRFQPTAKRR FRRQDIRNGD PSTLCSGDSS HSVLLEKKVL GVESGSAFLE CEPRSLQAHV
QWTFQGAGEA AHTQVLAEER VERTARGLLL RGLRRQDSGV YLCVAVEQGF SQPLRRLVLH
VLSAAQAERL ARAEEAAAPA PPGPKLWYRD FLQLVEPGGG GGANSLRMCR PQPGHHSVAA
DSRRKGRNRR MHVSELRAER GPRSAAHW
