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SEM3C_MOUSE
ID   SEM3C_MOUSE             Reviewed;         751 AA.
AC   Q62181; Q6NXW7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   03-AUG-2022, entry version 162.
DE   RecName: Full=Semaphorin-3C;
DE   AltName: Full=Semaphorin-E;
DE            Short=Sema E;
DE   Flags: Precursor;
GN   Name=Sema3c; Synonyms=Semae, SemE;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=NMRI; TISSUE=Embryo;
RX   PubMed=7748561; DOI=10.1016/0896-6273(95)90332-1;
RA   Pueschel A.W., Adams R.H., Betz H.;
RT   "Murine semaphorin D/collapsin is a member of a diverse gene family and
RT   creates domains inhibitory for axonal extension.";
RL   Neuron 14:941-948(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CD-1; TISSUE=Neural stem cell;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   DISRUPTION PHENOTYPE, AND FUNCTION.
RX   PubMed=11688556; DOI=10.1242/dev.128.16.3061;
RA   Feiner L., Webber A.L., Brown C.B., Lu M.M., Jia L., Feinstein P.,
RA   Mombaerts P., Epstein J.A., Raper J.A.;
RT   "Targeted disruption of semaphorin 3C leads to persistent truncus
RT   arteriosus and aortic arch interruption.";
RL   Development 128:3061-3070(2001).
RN   [5]
RP   FUNCTION, AND INTERACTION WITH PLXND1.
RX   PubMed=15239958; DOI=10.1016/j.devcel.2004.06.002;
RA   Gitler A.D., Lu M.M., Epstein J.A.;
RT   "PlexinD1 and semaphorin signaling are required in endothelial cells for
RT   cardiovascular development.";
RL   Dev. Cell 7:107-116(2004).
RN   [6]
RP   FUNCTION.
RX   PubMed=17021275; DOI=10.1093/cercor/bhl082;
RA   Gonthier B., Nasarre C., Roth L., Perraut M., Thomasset N., Roussel G.,
RA   Aunis D., Bagnard D.;
RT   "Functional interaction between matrix metalloproteinase-3 and semaphorin-
RT   3C during cortical axonal growth and guidance.";
RL   Cereb. Cortex 17:1712-1721(2007).
CC   -!- FUNCTION: Binds to plexin family members and plays an important role in
CC       the regulation of developmental processes. Required for normal
CC       cardiovascular development during embryogenesis. Functions as
CC       attractant for growing axons, and thereby plays an important role in
CC       axon growth and axon guidance. {ECO:0000269|PubMed:11688556,
CC       ECO:0000269|PubMed:15239958, ECO:0000269|PubMed:17021275}.
CC   -!- SUBUNIT: Interacts with PLXND1. {ECO:0000269|PubMed:15239958}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from day 10 in the embryo. Maximum
CC       expression between days 10-12 with moderate levels from day 13 until
CC       birth.
CC   -!- DISRUPTION PHENOTYPE: Perinatal lethality. Mice display severe defects
CC       in cardiovascular development, including aortic arch malformations and
CC       septation defects in the cardiac outflow tract.
CC       {ECO:0000269|PubMed:11688556}.
CC   -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
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DR   EMBL; X85994; CAA59986.1; -; mRNA.
DR   EMBL; CH466586; EDL03234.1; -; Genomic_DNA.
DR   EMBL; BC066852; AAH66852.1; -; mRNA.
DR   CCDS; CCDS19099.1; -.
DR   PIR; I48748; I48748.
DR   RefSeq; NP_038685.3; NM_013657.5.
DR   AlphaFoldDB; Q62181; -.
DR   SMR; Q62181; -.
DR   BioGRID; 203163; 3.
DR   STRING; 10090.ENSMUSP00000030568; -.
DR   GlyGen; Q62181; 7 sites.
DR   iPTMnet; Q62181; -.
DR   PhosphoSitePlus; Q62181; -.
DR   MaxQB; Q62181; -.
DR   PaxDb; Q62181; -.
DR   PeptideAtlas; Q62181; -.
DR   PRIDE; Q62181; -.
DR   ProteomicsDB; 261150; -.
DR   Antibodypedia; 48987; 280 antibodies from 27 providers.
DR   DNASU; 20348; -.
DR   Ensembl; ENSMUST00000030568; ENSMUSP00000030568; ENSMUSG00000028780.
DR   GeneID; 20348; -.
DR   KEGG; mmu:20348; -.
DR   UCSC; uc008wnl.1; mouse.
DR   CTD; 10512; -.
DR   MGI; MGI:107557; Sema3c.
DR   VEuPathDB; HostDB:ENSMUSG00000028780; -.
DR   eggNOG; KOG3611; Eukaryota.
DR   GeneTree; ENSGT00940000159379; -.
DR   HOGENOM; CLU_009051_5_0_1; -.
DR   InParanoid; Q62181; -.
DR   OMA; IGADYKY; -.
DR   OrthoDB; 157685at2759; -.
DR   PhylomeDB; Q62181; -.
DR   TreeFam; TF352628; -.
DR   BioGRID-ORCS; 20348; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Sema3c; mouse.
DR   PRO; PR:Q62181; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q62181; protein.
DR   Bgee; ENSMUSG00000028780; Expressed in ureter smooth muscle and 273 other tissues.
DR   ExpressionAtlas; Q62181; baseline and differential.
DR   Genevisible; Q62181; MM.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0045499; F:chemorepellent activity; IBA:GO_Central.
DR   GO; GO:0030215; F:semaphorin receptor binding; IPI:MGI.
DR   GO; GO:0007411; P:axon guidance; IDA:UniProtKB.
DR   GO; GO:0001974; P:blood vessel remodeling; IMP:MGI.
DR   GO; GO:0140074; P:cardiac endothelial to mesenchymal transition; IDA:BHF-UCL.
DR   GO; GO:0003215; P:cardiac right ventricle morphogenesis; IEP:BHF-UCL.
DR   GO; GO:0060666; P:dichotomous subdivision of terminal units involved in salivary gland branching; IDA:MGI.
DR   GO; GO:0007507; P:heart development; IMP:MGI.
DR   GO; GO:0060174; P:limb bud formation; IEP:BHF-UCL.
DR   GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR   GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IBA:GO_Central.
DR   GO; GO:0001755; P:neural crest cell migration; IMP:MGI.
DR   GO; GO:0021915; P:neural tube development; IEP:BHF-UCL.
DR   GO; GO:0003151; P:outflow tract morphogenesis; IEP:BHF-UCL.
DR   GO; GO:0003148; P:outflow tract septum morphogenesis; IMP:BHF-UCL.
DR   GO; GO:1905312; P:positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; IDA:BHF-UCL.
DR   GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0009791; P:post-embryonic development; IMP:MGI.
DR   GO; GO:0003350; P:pulmonary myocardium development; IEP:BHF-UCL.
DR   GO; GO:0071526; P:semaphorin-plexin signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0001756; P:somitogenesis; IEP:BHF-UCL.
DR   Gene3D; 2.130.10.10; -; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 1.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   1: Evidence at protein level;
KW   Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
KW   Immunoglobulin domain; Neurogenesis; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..751
FT                   /note="Semaphorin-3C"
FT                   /id="PRO_0000032312"
FT   DOMAIN          28..511
FT                   /note="Sema"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DOMAIN          571..655
FT                   /note="Ig-like C2-type"
FT   CARBOHYD        81
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        123
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        252
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        268
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        465
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        585
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        586
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        101..112
FT                   /evidence="ECO:0000250"
FT   DISULFID        130..139
FT                   /evidence="ECO:0000250"
FT   DISULFID        266..378
FT                   /evidence="ECO:0000250"
FT   DISULFID        290..338
FT                   /evidence="ECO:0000250"
FT   DISULFID        514..532
FT                   /evidence="ECO:0000250"
FT   DISULFID        643..709
FT                   /evidence="ECO:0000250"
FT   CONFLICT        206..208
FT                   /note="NAV -> MQL (in Ref. 1; CAA59986)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        412
FT                   /note="Y -> S (in Ref. 1; CAA59986)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        490
FT                   /note="K -> E (in Ref. 1; CAA59986)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        615
FT                   /note="V -> G (in Ref. 1; CAA59986)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   751 AA;  85289 MW;  32537E9D664123EE CRC64;
     MAFRAICVLV GVFICSICVR GSSQPQARVY LTFDELRETK TSEYFSLSHQ QLDYRILLMD
     EDQDRIYVGS KDHILSLNIN NISQEPLSVF WPASTIKVEE CKMAGKDPTH GCGNFVRVIQ
     TFNRTHLYVC GSGAFSPVCT YLNRGRRSED QVFMIDSKCE SGKGRCSFNP NVNTVSVMIN
     EELFSGMYID FMGTDAAIFR SLTKRNAVRT DQHNSKWLSE PMFVDAHVIP DGTDPNDAKV
     YFFFKERLTD NNRSTKQIHS MIARICPNDT GGQRSLVNKW TTFLKARLVC SVTDEDGPET
     HFDELEDVFL LETDNPRTTL VYGIFTTSSS VFKGSAVCVY HLSDIQTVFN GPFAHKEGPN
     HQLISYQGRI PYPRPGTCPG GAFTPNMRTT KDFPDDVVTF IRNHPLMYNS IYPIHRRPLI
     VRIGTDYKYT KIAVDRVNAA DGRYHVLFLG TDRGTVQKVV VLPTNSSASG ELILEELEVF
     KNHVPITTMK ISSKKQQLYV SSNEGVSQVS LHRCHIYGTA CADCCLARDP YCAWDGHSCS
     RFYPTGKRRS RRQDVRHGNP LTQCRGFNLK AYRNAAEIVQ YGVRNNSTFL ECAPKSPQAS
     IKWLLQKDKD RRKEVKLNER IIATSQGLLI RSVQDSDQGL YHCIATENSF KQTIAKINFK
     VLDSEMVAVV TDKWSPWTWA GSVRALPFHP KDILGAFSHS EMQLINQYCK DTRQQQQLGE
     EPQKMRGDYG KLKALINSRK SRNRRNQLPE S
 
 
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