SEM3D_DANRE
ID SEM3D_DANRE Reviewed; 764 AA.
AC Q9W6G6;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Semaphorin-3D;
DE AltName: Full=Semaphorin-2;
DE AltName: Full=Semaphorin-Z2;
DE Short=Sema Z2;
DE Flags: Precursor;
GN Name=sema3d; Synonyms=sema2, semaz2;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9915572;
RX DOI=10.1002/(sici)1097-0177(199901)214:1<13::aid-dvdy2>3.0.co;2-3;
RA Halloran M.C., Severance S.M., Yee C.S., Gemza D.L., Raper J.A.,
RA Kuwada J.Y.;
RT "Analysis of a zebrafish semaphorin reveals potential functions in vivo.";
RL Dev. Dyn. 214:13-25(1999).
CC -!- FUNCTION: May play a role in the guidance of several axon pathways.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed in a dynamic and restricted pattern
CC during the period of axon outgrowth.
CC -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
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DR EMBL; AF124485; AAD21310.1; -; mRNA.
DR AlphaFoldDB; Q9W6G6; -.
DR SMR; Q9W6G6; -.
DR STRING; 7955.ENSDARP00000111122; -.
DR PaxDb; Q9W6G6; -.
DR PRIDE; Q9W6G6; -.
DR ZFIN; ZDB-GENE-990715-2; sema3d.
DR eggNOG; KOG3611; Eukaryota.
DR InParanoid; Q9W6G6; -.
DR PhylomeDB; Q9W6G6; -.
DR PRO; PR:Q9W6G6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045499; F:chemorepellent activity; IBA:GO_Central.
DR GO; GO:0038191; F:neuropilin binding; IDA:ZFIN.
DR GO; GO:0030215; F:semaphorin receptor binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IMP:ZFIN.
DR GO; GO:0007413; P:axonal fasciculation; IMP:ZFIN.
DR GO; GO:0043534; P:blood vessel endothelial cell migration; IMP:ZFIN.
DR GO; GO:0010002; P:cardioblast differentiation; IMP:ZFIN.
DR GO; GO:0051216; P:cartilage development; IMP:ZFIN.
DR GO; GO:0021534; P:cell proliferation in hindbrain; IMP:ZFIN.
DR GO; GO:0035050; P:embryonic heart tube development; IMP:ZFIN.
DR GO; GO:0060272; P:embryonic skeletal joint morphogenesis; IMP:ZFIN.
DR GO; GO:0048484; P:enteric nervous system development; IMP:ZFIN.
DR GO; GO:0031101; P:fin regeneration; IMP:ZFIN.
DR GO; GO:0007508; P:larval heart development; IMP:ZFIN.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IBA:GO_Central.
DR GO; GO:0014032; P:neural crest cell development; IMP:ZFIN.
DR GO; GO:0014033; P:neural crest cell differentiation; IMP:ZFIN.
DR GO; GO:0001755; P:neural crest cell migration; IMP:ZFIN.
DR GO; GO:0071678; P:olfactory bulb axon guidance; IMP:ZFIN.
DR GO; GO:0007422; P:peripheral nervous system development; IMP:ZFIN.
DR GO; GO:0048936; P:peripheral nervous system neuron axonogenesis; IMP:ZFIN.
DR GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR GO; GO:0030516; P:regulation of axon extension; IMP:ZFIN.
DR GO; GO:0051726; P:regulation of cell cycle; IMP:ZFIN.
DR GO; GO:0031290; P:retinal ganglion cell axon guidance; IMP:ZFIN.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IBA:GO_Central.
DR GO; GO:0048538; P:thymus development; IMP:ZFIN.
DR CDD; cd11252; Sema_3D; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR042582; Sema3D_Sema.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; PTHR11036; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF101912; SSF101912; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Disulfide bond; Glycoprotein;
KW Immunoglobulin domain; Neurogenesis; Reference proteome; Secreted; Signal.
FT SIGNAL 1..41
FT /evidence="ECO:0000255"
FT CHAIN 42..764
FT /note="Semaphorin-3D"
FT /id="PRO_0000032316"
FT DOMAIN 48..535
FT /note="Sema"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DOMAIN 661..740
FT /note="Ig-like C2-type"
FT REGION 743..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 490
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 610
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 121..132
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DISULFID 150..159
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DISULFID 290..402
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DISULFID 314..362
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DISULFID 538..556
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DISULFID 668..733
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
SQ SEQUENCE 764 AA; 87860 MW; A3ED95C2C479D7AE CRC64;
MKTAGEPDRR RQRRQVRTGR FSCAWWSTSV MLFFSLPEGN CMKESLPRVK LGYKDLIHSR
SVVPFTGSSE GQHFQTVLLD EERSRLLLGA KDHVYLLDPD NINKHPKKLS WPASRDRVEM
CILAGKNPLT ECANFIRVLH SYNRTHVYAC GTGAFHPTCA FLEIKGHKED RWLLLHSNTM
ESGRMKCPFD PNQPFASVLT DQYLYAGTAS DFLGKDSTFT RSLGPPPHQQ YIRTDISEDY
WINEGKFISA HPISDTYNPD DDKIYFFFRE ASRDGSTTDK SVLSRVARIC RNDVGGLRSL
TNKWTTFLKA RLVCSIPGPD GVDTHFDELQ DIFLLPSRDE KNPMVYGVFT TTSSIFKGSA
VCVYTMEDIR AAFNGPYAHK EGPDHRWVEY EGRIPYPRPG TCPSRTYDPH IKTTKDFPDE
VISFIRLHPL MYQSVHPMTG RPIFTRINTE YRLTQIIVDR VAAEDGQYAV MFLGTDMGSV
LKVVSITQEN WSSEEIILEE LQVFKNPSPI LNMEVSSKQQ QLFVGGSDGL VQVSLHRCQI
YGQGCAECCL ARDPYCAWDG TQCSRYIPAS KRRARRQDIK HGDPSSHCWD TEDVLGRNVE
EKVLYGVESN SSFLECVSKS QQALIRWFVL KPGVDHRQEI KPDERVLITD RGLLIRWLQR
GDAGSYFCTS QEHRFTRTLL HVSLHILDRG QINAHQPAIR ESSENPAVTE PRQRYKDYLR
MLSGPARSLD EYCETMWHRE KKQKQKGKWK HVQELRKSRN RRHH
