SEM3F_HUMAN
ID SEM3F_HUMAN Reviewed; 785 AA.
AC Q13275; C9JQ85; Q13274; Q13372; Q15704; Q6GTR4;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 2.
DT 03-AUG-2022, entry version 188.
DE RecName: Full=Semaphorin-3F;
DE AltName: Full=Sema III/F;
DE AltName: Full=Semaphorin IV;
DE Short=Sema IV;
DE Flags: Precursor;
GN Name=SEMA3F;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Fetal brain;
RX PubMed=8649831;
RA Roche J., Boldog F., Robinson M., Robinson L., Varella-Garcia M.,
RA Swanton M., Waggoner B., Fishel R., Franklin W., Gemmill R., Drabkin H.;
RT "Distinct 3p21.3 deletions in lung cancer and identification of a new human
RT semaphorin.";
RL Oncogene 12:1289-1297(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT MET-503.
RC TISSUE=Fetal brain;
RX PubMed=8786119; DOI=10.1006/geno.1996.0074;
RA Xiang R.-H., Hensel C.H., Garcia D.K., Carlson H.C., Kok K., Daly M.C.,
RA Kerbacher K., van den Berg A., Veldhuis P., Buys C.H.C.M., Naylor S.L.;
RT "Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21,
RT a region deleted in lung cancer.";
RL Genomics 32:39-48(1996).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nelson J., Biewald T.;
RT "The sequence of H. sapiens cosmid clone LUCA19.";
RL Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT MET-503.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 394-436 (ISOFORM 1/2).
RC TISSUE=Placenta;
RX PubMed=8633026; DOI=10.1073/pnas.93.9.4120;
RA Sekido Y., Bader S., Latif F., Chen J.-Y., Duh F.-M., Wei M.-H.,
RA Albanesi J.P., Lee C.-C., Lerman M.I., Minna J.D.;
RT "Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer
RT deletion region and demonstrate distinct expression patterns.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:4120-4125(1996).
CC -!- FUNCTION: May play a role in cell motility and cell adhesion.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q13275-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q13275-2; Sequence=VSP_053417;
CC -!- TISSUE SPECIFICITY: Expressed abundantly but differentially in a
CC variety of neural and nonneural tissues. There is high expression in
CC mammary gland, kidney, fetal brain, and lung and lower expression in
CC heart and liver.
CC -!- DEVELOPMENTAL STAGE: Detected as early as embryonic day 10.
CC -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/SEMA3FID42254ch3p21.html";
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U33920; AAC50568.1; -; mRNA.
DR EMBL; U38276; AAB18276.1; -; mRNA.
DR EMBL; AC000063; AAB46344.1; -; Genomic_DNA.
DR EMBL; AC104450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC042914; AAH42914.1; -; mRNA.
DR EMBL; U32171; AAB06011.1; -; mRNA.
DR EMBL; U32172; AAB06012.1; -; mRNA.
DR CCDS; CCDS2811.1; -. [Q13275-1]
DR CCDS; CCDS82779.1; -. [Q13275-2]
DR PIR; G02173; G02173.
DR RefSeq; NP_001305729.1; NM_001318800.1. [Q13275-2]
DR RefSeq; NP_004177.3; NM_004186.4. [Q13275-1]
DR RefSeq; XP_005265438.1; XM_005265381.4. [Q13275-1]
DR RefSeq; XP_005265439.1; XM_005265382.4. [Q13275-2]
DR RefSeq; XP_011532300.1; XM_011533998.2. [Q13275-1]
DR AlphaFoldDB; Q13275; -.
DR SMR; Q13275; -.
DR BioGRID; 112305; 10.
DR IntAct; Q13275; 2.
DR STRING; 9606.ENSP00000002829; -.
DR GlyConnect; 1731; 3 N-Linked glycans (2 sites).
DR GlyGen; Q13275; 3 sites, 4 N-linked glycans (2 sites), 1 O-linked glycan (1 site).
DR iPTMnet; Q13275; -.
DR PhosphoSitePlus; Q13275; -.
DR BioMuta; SEMA3F; -.
DR DMDM; 8134696; -.
DR EPD; Q13275; -.
DR MassIVE; Q13275; -.
DR MaxQB; Q13275; -.
DR PaxDb; Q13275; -.
DR PeptideAtlas; Q13275; -.
DR PRIDE; Q13275; -.
DR ProteomicsDB; 11213; -.
DR ProteomicsDB; 59270; -. [Q13275-1]
DR Antibodypedia; 30785; 208 antibodies from 29 providers.
DR DNASU; 6405; -.
DR Ensembl; ENST00000002829.8; ENSP00000002829.3; ENSG00000001617.12. [Q13275-1]
DR Ensembl; ENST00000434342.5; ENSP00000409859.1; ENSG00000001617.12. [Q13275-2]
DR GeneID; 6405; -.
DR KEGG; hsa:6405; -.
DR MANE-Select; ENST00000002829.8; ENSP00000002829.3; NM_004186.5; NP_004177.3.
DR UCSC; uc003cyj.4; human. [Q13275-1]
DR CTD; 6405; -.
DR DisGeNET; 6405; -.
DR GeneCards; SEMA3F; -.
DR HGNC; HGNC:10728; SEMA3F.
DR HPA; ENSG00000001617; Tissue enhanced (esophagus).
DR MIM; 601124; gene.
DR neXtProt; NX_Q13275; -.
DR OpenTargets; ENSG00000001617; -.
DR PharmGKB; PA35650; -.
DR VEuPathDB; HostDB:ENSG00000001617; -.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000156703; -.
DR InParanoid; Q13275; -.
DR OMA; QDYLPAT; -.
DR OrthoDB; 157685at2759; -.
DR PhylomeDB; Q13275; -.
DR TreeFam; TF352628; -.
DR PathwayCommons; Q13275; -.
DR SignaLink; Q13275; -.
DR SIGNOR; Q13275; -.
DR BioGRID-ORCS; 6405; 9 hits in 1070 CRISPR screens.
DR ChiTaRS; SEMA3F; human.
DR GeneWiki; SEMA3F; -.
DR GenomeRNAi; 6405; -.
DR Pharos; Q13275; Tbio.
DR PRO; PR:Q13275; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q13275; protein.
DR Bgee; ENSG00000001617; Expressed in cervix squamous epithelium and 204 other tissues.
DR ExpressionAtlas; Q13275; baseline and differential.
DR Genevisible; Q13275; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045499; F:chemorepellent activity; IDA:MGI.
DR GO; GO:0030215; F:semaphorin receptor binding; IBA:GO_Central.
DR GO; GO:0048846; P:axon extension involved in axon guidance; ISS:BHF-UCL.
DR GO; GO:0007411; P:axon guidance; IDA:MGI.
DR GO; GO:0021785; P:branchiomotor neuron axon guidance; IEA:Ensembl.
DR GO; GO:0021612; P:facial nerve structural organization; IEA:Ensembl.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IBA:GO_Central.
DR GO; GO:0021675; P:nerve development; ISS:BHF-UCL.
DR GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
DR GO; GO:1901166; P:neural crest cell migration involved in autonomic nervous system development; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR GO; GO:0099175; P:regulation of postsynapse organization; IEA:Ensembl.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IBA:GO_Central.
DR GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IEA:Ensembl.
DR GO; GO:1902285; P:semaphorin-plexin signaling pathway involved in neuron projection guidance; ISS:BHF-UCL.
DR GO; GO:0061549; P:sympathetic ganglion development; ISS:BHF-UCL.
DR GO; GO:0097490; P:sympathetic neuron projection extension; ISS:BHF-UCL.
DR GO; GO:0097491; P:sympathetic neuron projection guidance; ISS:BHF-UCL.
DR GO; GO:0021637; P:trigeminal nerve structural organization; IEA:Ensembl.
DR GO; GO:0036486; P:ventral trunk neural crest cell migration; IEA:Ensembl.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; PTHR11036; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF101912; SSF101912; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..785
FT /note="Semaphorin-3F"
FT /id="PRO_0000032320"
FT DOMAIN 31..545
FT /note="Sema"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DOMAIN 605..690
FT /note="Ig-like C2-type"
FT REGION 752..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..785
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..115
FT /evidence="ECO:0000250"
FT DISULFID 133..142
FT /evidence="ECO:0000250"
FT DISULFID 300..412
FT /evidence="ECO:0000250"
FT DISULFID 324..372
FT /evidence="ECO:0000250"
FT DISULFID 548..566
FT /evidence="ECO:0000250"
FT DISULFID 678..746
FT /evidence="ECO:0000250"
FT VAR_SEQ 153..183
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8786119"
FT /id="VSP_053417"
FT VARIANT 474
FT /note="A -> G (in dbSNP:rs1046955)"
FT /id="VAR_011820"
FT VARIANT 503
FT /note="L -> M (in dbSNP:rs1046956)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:8786119"
FT /id="VAR_008855"
FT CONFLICT 270
FT /note="Missing (in Ref. 2; AAB18276)"
FT /evidence="ECO:0000305"
FT CONFLICT 473
FT /note="A -> S (in Ref. 2; AAB18276)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 785 AA; 88381 MW; FE3FC796EEC1608E CRC64;
MLVAGLLLWA SLLTGAWPSF PTQDHLPATP RVRLSFKELK ATGTAHFFNF LLNTTDYRIL
LKDEDHDRMY VGSKDYVLSL DLHDINREPL IIHWAASPQR IEECVLSGKD VNGECGNFVR
LIQPWNRTHL YVCGTGAYNP MCTYVNRGRR AQATPWTQTQ AVRGRGSRAT DGALRPMPTA
PRQDYIFYLE PERLESGKGK CPYDPKLDTA SALINEELYA GVYIDFMGTD AAIFRTLGKQ
TAMRTDQYNS RWLNDPSFIH AELIPDSAER NDDKLYFFFR ERSAEAPQSP AVYARIGRIC
LNDDGGHCCL VNKWSTFLKA RLVCSVPGED GIETHFDELQ DVFVQQTQDV RNPVIYAVFT
SSGSVFRGSA VCVYSMADIR MVFNGPFAHK EGPNYQWMPF SGKMPYPRPG TCPGGTFTPS
MKSTKDYPDE VINFMRSHPL MYQAVYPLQR RPLVVRTGAP YRLTTIAVDQ VDAADGRYEV
LFLGTDRGTV QKVIVLPKDD QELEELMLEE VEVFKDPAPV KTMTISSKRQ QLYVASAVGV
THLSLHRCQA YGAACADCCL ARDPYCAWDG QACSRYTASS KRRSRRQDVR HGNPIRQCRG
FNSNANKNAV ESVQYGVAGS AAFLECQPRS PQATVKWLFQ RDPGDRRREI RAEDRFLRTE
QGLLLRALQL SDRGLYSCTA TENNFKHVVT RVQLHVLGRD AVHAALFPPL SMSAPPPPGA
GPPTPPYQEL AQLLAQPEVG LIHQYCQGYW RHVPPSPREA PGAPRSPEPQ DQKKPRNRRH
HPPDT
