SEM3F_MOUSE
ID SEM3F_MOUSE Reviewed; 785 AA.
AC O88632; E9QNC5; O88633;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Semaphorin-3F;
DE AltName: Full=Semaphorin IV;
DE Short=Sema IV;
DE Flags: Precursor;
GN Name=Sema3f;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B).
RX PubMed=9875739; DOI=10.1097/00001756-199812010-00038;
RA Eckhardt F., Meyerhans A.;
RT "Cloning and expression pattern of a murine semaphorin homologous to H-sema
RT IV.";
RL NeuroReport 9:3975-3979(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=B;
CC IsoId=O88632-1; Sequence=Displayed;
CC Name=A;
CC IsoId=O88632-2; Sequence=VSP_006042;
CC -!- TISSUE SPECIFICITY: Expressed ubiquitously in adulthood. During
CC embryogenesis, expressed in subregions of the central nervous system
CC and various other tissues like skin, kidney, lung and intestine.
CC -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
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DR EMBL; AF080090; AAC28108.1; -; mRNA.
DR EMBL; AF080091; AAC28109.1; -; mRNA.
DR EMBL; AC152718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC162905; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC010976; AAH10976.1; -; mRNA.
DR CCDS; CCDS23505.1; -. [O88632-2]
DR CCDS; CCDS81069.1; -. [O88632-1]
DR RefSeq; NP_001298080.1; NM_001311151.1. [O88632-1]
DR RefSeq; NP_035479.2; NM_011349.3. [O88632-2]
DR RefSeq; XP_006511739.1; XM_006511676.3.
DR RefSeq; XP_017168717.1; XM_017313228.1. [O88632-1]
DR AlphaFoldDB; O88632; -.
DR SMR; O88632; -.
DR BioGRID; 203165; 4.
DR STRING; 10090.ENSMUSP00000079400; -.
DR GlyGen; O88632; 2 sites.
DR PhosphoSitePlus; O88632; -.
DR MaxQB; O88632; -.
DR PaxDb; O88632; -.
DR PRIDE; O88632; -.
DR ProteomicsDB; 256613; -. [O88632-1]
DR ProteomicsDB; 256614; -. [O88632-2]
DR Antibodypedia; 30785; 208 antibodies from 29 providers.
DR DNASU; 20350; -.
DR Ensembl; ENSMUST00000080560; ENSMUSP00000079400; ENSMUSG00000034684. [O88632-2]
DR Ensembl; ENSMUST00000192727; ENSMUSP00000141865; ENSMUSG00000034684. [O88632-1]
DR GeneID; 20350; -.
DR KEGG; mmu:20350; -.
DR UCSC; uc009rms.1; mouse. [O88632-1]
DR UCSC; uc009rmt.1; mouse. [O88632-2]
DR CTD; 6405; -.
DR MGI; MGI:1096347; Sema3f.
DR VEuPathDB; HostDB:ENSMUSG00000034684; -.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000156703; -.
DR HOGENOM; CLU_009051_5_0_1; -.
DR InParanoid; O88632; -.
DR OMA; QDYLPAT; -.
DR OrthoDB; 157685at2759; -.
DR TreeFam; TF352628; -.
DR BioGRID-ORCS; 20350; 4 hits in 75 CRISPR screens.
DR PRO; PR:O88632; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; O88632; protein.
DR Bgee; ENSMUSG00000034684; Expressed in ectoplacental cone and 174 other tissues.
DR ExpressionAtlas; O88632; baseline and differential.
DR Genevisible; O88632; MM.
DR GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR GO; GO:0098978; C:glutamatergic synapse; IDA:SynGO.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045499; F:chemorepellent activity; IDA:MGI.
DR GO; GO:0030215; F:semaphorin receptor binding; IBA:GO_Central.
DR GO; GO:0048846; P:axon extension involved in axon guidance; IDA:MGI.
DR GO; GO:0007411; P:axon guidance; IDA:MGI.
DR GO; GO:0021785; P:branchiomotor neuron axon guidance; IMP:ParkinsonsUK-UCL.
DR GO; GO:0021612; P:facial nerve structural organization; IMP:ParkinsonsUK-UCL.
DR GO; GO:0040011; P:locomotion; IC:GOC-OWL.
DR GO; GO:0050919; P:negative chemotaxis; IDA:MGI.
DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IDA:MGI.
DR GO; GO:0021675; P:nerve development; IMP:BHF-UCL.
DR GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
DR GO; GO:1901166; P:neural crest cell migration involved in autonomic nervous system development; IMP:ParkinsonsUK-UCL.
DR GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR GO; GO:0099175; P:regulation of postsynapse organization; IDA:SynGO.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IBA:GO_Central.
DR GO; GO:1902287; P:semaphorin-plexin signaling pathway involved in axon guidance; IMP:ParkinsonsUK-UCL.
DR GO; GO:1902285; P:semaphorin-plexin signaling pathway involved in neuron projection guidance; IMP:BHF-UCL.
DR GO; GO:0061549; P:sympathetic ganglion development; IMP:BHF-UCL.
DR GO; GO:0097490; P:sympathetic neuron projection extension; IMP:BHF-UCL.
DR GO; GO:0097491; P:sympathetic neuron projection guidance; IMP:BHF-UCL.
DR GO; GO:0021637; P:trigeminal nerve structural organization; IMP:ParkinsonsUK-UCL.
DR GO; GO:0036484; P:trunk neural crest cell migration; IMP:MGI.
DR GO; GO:0036486; P:ventral trunk neural crest cell migration; IMP:ParkinsonsUK-UCL.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; PTHR11036; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF101912; SSF101912; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..785
FT /note="Semaphorin-3F"
FT /id="PRO_0000032321"
FT DOMAIN 31..545
FT /note="Sema"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DOMAIN 605..695
FT /note="Ig-like C2-type"
FT REGION 583..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 753..785
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..785
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 53
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 104..115
FT /evidence="ECO:0000250"
FT DISULFID 133..142
FT /evidence="ECO:0000250"
FT DISULFID 300..412
FT /evidence="ECO:0000250"
FT DISULFID 324..372
FT /evidence="ECO:0000250"
FT DISULFID 548..566
FT /evidence="ECO:0000250"
FT DISULFID 678..746
FT /evidence="ECO:0000250"
FT VAR_SEQ 153..183
FT /note="Missing (in isoform A)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:9875739"
FT /id="VSP_006042"
FT CONFLICT 350
FT /note="V -> I (in Ref. 1; AAC28108/AAC28109 and 3;
FT AAH10976)"
FT /evidence="ECO:0000305"
FT CONFLICT 756
FT /note="R -> S (in Ref. 1; AAC28108/AAC28109 and 3;
FT AAH10976)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 785 AA; 88549 MW; 8F3F0935096C24A1 CRC64;
MLVTAFILWA SLLTGAWPAT PIQDQLPATP RVRLSFKELK ATGTAHFFNF LLNTTDYRIL
LKDEDHDRMY VGSKDYVLSL DLHDINREPL IIHWAASPQR IEECILSGKD GNGECGNFVR
LIQPWNRTHL YVCGTGAYNP MCTYVNRGRR AQALPWTQMQ VVRGRGSRAT DGADRPTPTA
PRQDYIFYLE PEKLESGKGK CPYDPKLDTA SALINEELYA GVYIDFMGTD AAIFRTLGKQ
TAMRTDQYNS RWLNDPSFIH AELIPDSAER NDDKLYFFFR ERSAEAPQNP AVYARIGRIC
LNDDGGHCCL VNKWSTFLKA RLVCSVPGED GIETHFDELQ DVFVQQTQDV RNPVIYAVFT
SSGSVFRGSA VCVYSMADIR MVFNGPFAHK EGPNYQWMPF SGKMPYPRPG TCPGGTFTPS
MKSTKDYPDE VINFMRTHPL MYQAVYPLQR RPLVVRTGAP YRLTTVAVDQ VDAADGRYEV
LFLGTDRGTV QKVIVLPKDD QEVEELMLEE VEVFKEPAPV KTMTISSKRQ QLYVASAVGV
THLSLHRCQA YGAACADCCL ARDPYCAWDG QACSRYTASS KRRSRRQDVR HGNPIRQCRG
FNSNANKNAV ESVQYGVAGS AAFLECQPRS PQATVKWLFQ RDPSDRRREI RAEDRFLRTE
QGLLLRALQL GDRGLYSCTA TENNFKHIVT RVQLHVLGRD AVHAALFPPL AVSVPPPPGT
GPPTPPYQEL AQLLAQPEVG LIHQYCQGYW RHVPPRPREA PGALRPPELQ DQKKPRNRRH
HPPDT
