SEM3G_HUMAN
ID SEM3G_HUMAN Reviewed; 782 AA.
AC Q9NS98; Q7L9D9; Q9H7Q3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Semaphorin-3G;
DE AltName: Full=Semaphorin sem2;
DE Flags: Precursor;
GN Name=SEMA3G;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Miyajima N.,
RA Saito T.;
RT "Human semaphorin.";
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Has chemorepulsive activities for sympathetic axons. Ligand
CC of NRP2 (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q9NS98; Q9BSY9: DESI2; NbExp=3; IntAct=EBI-17574989, EBI-12878374;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
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DR EMBL; AB029496; BAA98132.1; -; mRNA.
DR EMBL; AK024425; BAB15715.1; -; mRNA.
DR EMBL; BC098104; AAH98104.1; -; mRNA.
DR EMBL; BC098137; AAH98137.1; -; mRNA.
DR EMBL; BC099724; AAH99724.1; -; mRNA.
DR CCDS; CCDS2856.1; -.
DR RefSeq; NP_064548.1; NM_020163.2.
DR AlphaFoldDB; Q9NS98; -.
DR SMR; Q9NS98; -.
DR BioGRID; 121248; 6.
DR IntAct; Q9NS98; 1.
DR STRING; 9606.ENSP00000231721; -.
DR GlyConnect; 1732; 1 N-Linked glycan (1 site).
DR GlyGen; Q9NS98; 2 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q9NS98; -.
DR PhosphoSitePlus; Q9NS98; -.
DR BioMuta; SEMA3G; -.
DR DMDM; 74761676; -.
DR jPOST; Q9NS98; -.
DR MassIVE; Q9NS98; -.
DR PaxDb; Q9NS98; -.
DR PeptideAtlas; Q9NS98; -.
DR PRIDE; Q9NS98; -.
DR ProteomicsDB; 82517; -.
DR Antibodypedia; 937; 130 antibodies from 19 providers.
DR DNASU; 56920; -.
DR Ensembl; ENST00000231721.7; ENSP00000231721.2; ENSG00000010319.7.
DR GeneID; 56920; -.
DR KEGG; hsa:56920; -.
DR MANE-Select; ENST00000231721.7; ENSP00000231721.2; NM_020163.3; NP_064548.1.
DR UCSC; uc003dea.2; human.
DR CTD; 56920; -.
DR DisGeNET; 56920; -.
DR GeneCards; SEMA3G; -.
DR HGNC; HGNC:30400; SEMA3G.
DR HPA; ENSG00000010319; Tissue enhanced (adipose tissue, breast).
DR neXtProt; NX_Q9NS98; -.
DR OpenTargets; ENSG00000010319; -.
DR PharmGKB; PA142670937; -.
DR VEuPathDB; HostDB:ENSG00000010319; -.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000157677; -.
DR HOGENOM; CLU_009051_5_0_1; -.
DR InParanoid; Q9NS98; -.
DR OMA; WPVRPRH; -.
DR OrthoDB; 158418at2759; -.
DR PhylomeDB; Q9NS98; -.
DR TreeFam; TF316102; -.
DR PathwayCommons; Q9NS98; -.
DR SignaLink; Q9NS98; -.
DR BioGRID-ORCS; 56920; 11 hits in 1070 CRISPR screens.
DR ChiTaRS; SEMA3G; human.
DR GenomeRNAi; 56920; -.
DR Pharos; Q9NS98; Tbio.
DR PRO; PR:Q9NS98; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9NS98; protein.
DR Bgee; ENSG00000010319; Expressed in renal glomerulus and 186 other tissues.
DR ExpressionAtlas; Q9NS98; baseline and differential.
DR Genevisible; Q9NS98; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045499; F:chemorepellent activity; IBA:GO_Central.
DR GO; GO:0030215; F:semaphorin receptor binding; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; ISS:UniProtKB.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR GO; GO:0030517; P:negative regulation of axon extension; ISS:UniProtKB.
DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IBA:GO_Central.
DR GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; PTHR11036; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF101912; SSF101912; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..782
FT /note="Semaphorin-3G"
FT /id="PRO_0000257791"
FT DOMAIN 32..519
FT /note="Sema"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DOMAIN 569..671
FT /note="Ig-like C2-type"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..116
FT /evidence="ECO:0000250"
FT DISULFID 134..143
FT /evidence="ECO:0000250"
FT DISULFID 270..382
FT /evidence="ECO:0000250"
FT DISULFID 294..342
FT /evidence="ECO:0000250"
FT DISULFID 522..540
FT /evidence="ECO:0000250"
FT DISULFID 603..655
FT /evidence="ECO:0000250"
FT VARIANT 180
FT /note="S -> N (in dbSNP:rs35811072)"
FT /id="VAR_051929"
FT VARIANT 232
FT /note="I -> T (in dbSNP:rs2276833)"
FT /id="VAR_030292"
FT VARIANT 332
FT /note="V -> I (in dbSNP:rs34540591)"
FT /id="VAR_051930"
SQ SEQUENCE 782 AA; 86701 MW; 85CB424874DF6663 CRC64;
MAPSAWAICW LLGGLLLHGG SSGPSPGPSV PRLRLSYRDL LSANRSAIFL GPQGSLNLQA
MYLDEYRDRL FLGGLDALYS LRLDQAWPDP REVLWPPQPG QREECVRKGR DPLTECANFV
RVLQPHNRTH LLACGTGAFQ PTCALITVGH RGEHVLHLEP GSVESGRGRC PHEPSRPFAS
TFIDGELYTG LTADFLGREA MIFRSGGPRP ALRSDSDQSL LHDPRFVMAA RIPENSDQDN
DKVYFFFSET VPSPDGGSNH VTVSRVGRVC VNDAGGQRVL VNKWSTFLKA RLVCSVPGPG
GAETHFDQLE DVFLLWPKAG KSLEVYALFS TVSAVFQGFA VCVYHMADIW EVFNGPFAHR
DGPQHQWGPY GGKVPFPRPG VCPSKMTAQP GRPFGSTKDY PDEVLQFARA HPLMFWPVRP
RHGRPVLVKT HLAQQLHQIV VDRVEAEDGT YDVIFLGTDS GSVLKVIALQ AGGSAEPEEV
VLEELQVFKV PTPITEMEIS VKRQMLYVGS RLGVAQLRLH QCETYGTACA ECCLARDPYC
AWDGASCTHY RPSLGKRRFR RQDIRHGNPA LQCLGQSQEE EAVGLVAATM VYGTEHNSTF
LECLPKSPQA AVRWLLQRPG DEGPDQVKTD ERVLHTERGL LFRRLSRFDA GTYTCTTLEH
GFSQTVVRLA LVVIVASQLD NLFPPEPKPE EPPARGGLAS TPPKAWYKDI LQLIGFANLP
RVDEYCERVW CRGTTECSGC FRSRSRGKQA RGKSWAGLEL GKKMKSRVHA EHNRTPREVE
AT
