ID   BGBP_PENMO              Reviewed;         366 AA.
AC   Q8N0N3;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Beta-1,3-glucan-binding protein {ECO:0000312|EMBL:AAM21213.1};
DE            Short=GBP {ECO:0000303|PubMed:11755673};
DE   Flags: Precursor;
OS   Penaeus monodon (Giant tiger prawn).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata;
OC   Penaeoidea; Penaeidae; Penaeus.
OX   NCBI_TaxID=6687;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAM21213.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC   TISSUE=Hemocyte {ECO:0000269|PubMed:11755673};
RX   PubMed=11755673; DOI=10.1016/s0145-305x(01)00074-x;
RA   Sritunyalucksana K., Lee S.Y., Soderhall K.;
RT   "A beta-1,3-glucan binding protein from the black tiger shrimp, Penaeus
RT   monodon.";
RL   Dev. Comp. Immunol. 26:237-245(2002).
CC   -!- FUNCTION: Binds to beta-1,3-glucan. May play a role in recognition of
CC       microorganisms and in activation of the prophenoloxidase cascade.
CC       {ECO:0000269|PubMed:11755673}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Constitutively expressed in hemocytes.
CC       {ECO:0000269|PubMed:11755673}.
CC   -!- INDUCTION: Not induced by injection with the beta-1,3-glucan curdlan or
CC       the shrimp pathogen V.harveyi. {ECO:0000269|PubMed:11755673}.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 16 family. {ECO:0000305}.
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DR   EMBL; AF368168; AAM21213.1; -; mRNA.
DR   AlphaFoldDB; Q8N0N3; -.
DR   SMR; Q8N0N3; -.
DR   CAZy; GH16; Glycoside Hydrolase Family 16.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001872; F:(1->3)-beta-D-glucan binding; IDA:UniProtKB.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; NAS:UniProtKB.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000757; GH16.
DR   Pfam; PF00722; Glyco_hydro_16; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51762; GH16_2; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Immunity; Innate immunity; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..366
FT                   /note="Beta-1,3-glucan-binding protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000407278"
FT   DOMAIN          18..364
FT                   /note="GH16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01098"
FT   CARBOHYD        66
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   366 AA;  41497 MW;  6F540A60E83FDD7D CRC64;
     MKGFVASVVL LACGALAADI VEPEDCTSFP CMIFEDNFDY LDNDIWEHEI TMSGGGNWEF
     QAYVNNRSIS YTRDSTLFIK PDLTSNWKGE DFLSSGTLDL WGMNGRGDVC TGNSYYGCSR
     VGSSSNIINP VTSARLRTMS NFAFRYGRLE VRAKMPRGDW LWPAIWMLPR NWPYGLWPAS
     GEIDILESRG NDDFGTLGNQ YGGTTLHWGP FWPYNFFEKT HAEYSANTGS FADDFHVWRL
     DWTKDNMEFY VDDVLQLTVD PGTSFWDFAG MGPFFDNPWA AGAKMAPFDQ KFYLILNVAV
     GGTNGFFPDG IASKPWSNLS PTAFLDFWNA RDEWLPSWKA GEDRISEGAA MQVDYVRVWK
     MESTEQ