SEM3G_MOUSE
ID SEM3G_MOUSE Reviewed; 780 AA.
AC Q4LFA9; Q3UVA7;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2005, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Semaphorin-3G;
DE Flags: Precursor;
GN Name=Sema3g;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SPECIFICITY.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=16098142; DOI=10.1111/j.1365-2443.2005.00877.x;
RA Taniguchi M., Masuda T., Fukaya M., Kataoka H., Mishina M., Yaginuma H.,
RA Watanabe M., Shimizu T.;
RT "Identification and characterization of a novel member of murine semaphorin
RT family.";
RL Genes Cells 10:785-792(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Has chemorepulsive activities for sympathetic axons. Ligand
CC of NRP2. {ECO:0000269|PubMed:16098142}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Highly expressed in lung and kidney. Weakly
CC expressed in brain.
CC -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
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DR EMBL; AB127607; BAE06156.1; -; mRNA.
DR EMBL; AK137463; BAE23363.1; -; mRNA.
DR CCDS; CCDS26908.1; -.
DR RefSeq; NP_001020550.1; NM_001025379.1.
DR AlphaFoldDB; Q4LFA9; -.
DR SMR; Q4LFA9; -.
DR BioGRID; 230073; 1.
DR STRING; 10090.ENSMUSP00000087643; -.
DR GlyConnect; 2695; 1 N-Linked glycan (1 site).
DR GlyGen; Q4LFA9; 3 sites, 1 N-linked glycan (1 site).
DR iPTMnet; Q4LFA9; -.
DR PhosphoSitePlus; Q4LFA9; -.
DR MaxQB; Q4LFA9; -.
DR PaxDb; Q4LFA9; -.
DR PeptideAtlas; Q4LFA9; -.
DR PRIDE; Q4LFA9; -.
DR ProteomicsDB; 261151; -.
DR Antibodypedia; 937; 130 antibodies from 19 providers.
DR Ensembl; ENSMUST00000090180; ENSMUSP00000087643; ENSMUSG00000021904.
DR GeneID; 218877; -.
DR KEGG; mmu:218877; -.
DR UCSC; uc007sxe.1; mouse.
DR CTD; 56920; -.
DR MGI; MGI:3041242; Sema3g.
DR VEuPathDB; HostDB:ENSMUSG00000021904; -.
DR eggNOG; KOG3611; Eukaryota.
DR GeneTree; ENSGT00940000157677; -.
DR HOGENOM; CLU_009051_5_0_1; -.
DR InParanoid; Q4LFA9; -.
DR OMA; WPVRPRH; -.
DR OrthoDB; 158418at2759; -.
DR PhylomeDB; Q4LFA9; -.
DR TreeFam; TF316102; -.
DR BioGRID-ORCS; 218877; 0 hits in 73 CRISPR screens.
DR PRO; PR:Q4LFA9; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q4LFA9; protein.
DR Bgee; ENSMUSG00000021904; Expressed in right lung and 174 other tissues.
DR Genevisible; Q4LFA9; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0045499; F:chemorepellent activity; IBA:GO_Central.
DR GO; GO:0030215; F:semaphorin receptor binding; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IPI:UniProtKB.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR GO; GO:0030517; P:negative regulation of axon extension; IDA:UniProtKB.
DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IBA:GO_Central.
DR GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
DR GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR GO; GO:0071526; P:semaphorin-plexin signaling pathway; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; PTHR11036; 1.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF01403; Sema; 1.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF101912; SSF101912; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..780
FT /note="Semaphorin-3G"
FT /id="PRO_0000257792"
FT DOMAIN 32..519
FT /note="Sema"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT DOMAIN 569..671
FT /note="Ig-like C2-type"
FT CARBOHYD 44
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 127
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 652
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 105..116
FT /evidence="ECO:0000250"
FT DISULFID 134..143
FT /evidence="ECO:0000250"
FT DISULFID 270..382
FT /evidence="ECO:0000250"
FT DISULFID 294..342
FT /evidence="ECO:0000250"
FT DISULFID 522..540
FT /evidence="ECO:0000250"
FT DISULFID 603..655
FT /evidence="ECO:0000250"
FT CONFLICT 385
FT /note="K -> R (in Ref. 2; BAE23363)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 780 AA; 86695 MW; 433F4D96F53CB4A5 CRC64;
MDPSAWAICC LLGSLLFHVG IPSPGPSPSV PRLRLSYRDL LSTNRSAIFL GPRGSLDLQV
MYLDEYRDRL FLGSRDALYS LRLDQAWPDP REVLWLPQPG QKVECVRKGK DPLTECANFV
RVLQPHNRTH LLACGTGAFQ PICTFITVGH RGEHVLRLDA SSVENGRGRC PHEPSRPFAS
TFVGGELYTG LTADFLGREA MIFRSGGPRP ALRSDSDQSL LHEPRFVMAA RIPDNSDRDD
DKVYFFFSET VPSPDGGPGH VTISRVGRVC VNDAGGQRVL VNKWSTFLKA RLVCSVPGPG
GAETHFDQLE DVFLLWPKAG KSLEVYALFS TVSAVFQGFA VCVYHMVDIW EVFNGPFAHR
DGPQHQWGPY GGKVPFPRPG VCPSKMTAQP GRPFGSTKDY PDEVLQFVRD HPLMFQPVRP
RRGRPVLVKT HLAQRLRQIV VDRVEAEDGT YDVIFLGTDS GSVLKVIALQ GGGLTEPEEV
VLEELQVFKV PTPITEMEIS VKRQTLYVGS PLGVARLQLH QCETYGSACA ECCLARDPYC
AWDGTACARY RPSSGKRRFR RQDIRHGNPA VQCLGQGQSQ NKAASGLMTR VFGTEHNSTF
LECLPKSPQA AVRWFLQRPG DKGTDQVKTD ERVVQTAQGL LFRRLSRHDA GNYTCTTLEH
GFSQTVVRFA LEVIAAVQLD SLFLRESRLE EPSAWGSLAS ASPKTWYKDI LQLTGFANLP
RVDEYCERVW CRGVGERSGS FRGKGKQAKG KSWAGLELGK KMKSRVLAEH NRTPREVEAT
