ID   SEM4D_CHICK             Reviewed;         295 AA.
AC   Q90665;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Semaphorin-4D;
DE   AltName: Full=Collapsin-4;
DE            Short=COLL-4;
DE   Flags: Fragment;
GN   Name=SEMA4D; Synonyms=COLL4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7605628; DOI=10.1016/0896-6273(95)90261-9;
RA   Luo Y., Shepherd I., Li J., Renzi M.J., Chang S., Raper J.A.;
RT   "A family of molecules related to collapsin in the embryonic chick nervous
RT   system.";
RL   Neuron 14:1131-1140(1995).
CC   -!- FUNCTION: Cell surface receptor for PLXNB1 that plays an important role
CC       in cell-cell signaling (By similarity). Regulates GABAergic synapse
CC       development (By similarity). Promotes the development of inhibitory
CC       synapses in a PLXNB1-dependent manner (By similarity). Modulates the
CC       complexity and arborization of developing neurites in hippocampal
CC       neurons by activating PLXNB1 and interaction with PLXNB1 mediates
CC       activation of RHOA (By similarity). {ECO:0000250|UniProtKB:O09126,
CC       ECO:0000250|UniProtKB:Q92854}.
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with PLXNB1 (By
CC       similarity). {ECO:0000250|UniProtKB:Q92854}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q92854};
CC       Single-pass type I membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
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DR   EMBL; U28242; AAA86898.1; -; mRNA.
DR   RefSeq; NP_001280031.1; NM_001293102.1.
DR   AlphaFoldDB; Q90665; -.
DR   SMR; Q90665; -.
DR   STRING; 9031.ENSGALP00000037144; -.
DR   PaxDb; Q90665; -.
DR   GeneID; 396331; -.
DR   KEGG; gga:396331; -.
DR   CTD; 10507; -.
DR   VEuPathDB; HostDB:geneid_396331; -.
DR   eggNOG; KOG3611; Eukaryota.
DR   InParanoid; Q90665; -.
DR   OrthoDB; 64683at2759; -.
DR   PhylomeDB; Q90665; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0045499; F:chemorepellent activity; IBA:GO_Central.
DR   GO; GO:0030215; F:semaphorin receptor binding; IBA:GO_Central.
DR   GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR   GO; GO:0050919; P:negative chemotaxis; IBA:GO_Central.
DR   GO; GO:0010693; P:negative regulation of alkaline phosphatase activity; IBA:GO_Central.
DR   GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
DR   GO; GO:0043931; P:ossification involved in bone maturation; IBA:GO_Central.
DR   GO; GO:0030335; P:positive regulation of cell migration; IBA:GO_Central.
DR   GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR   GO; GO:1905704; P:positive regulation of inhibitory synapse assembly; ISS:UniProtKB.
DR   GO; GO:0071526; P:semaphorin-plexin signaling pathway; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Developmental protein; Differentiation; Disulfide bond;
KW   Glycoprotein; Membrane; Neurogenesis; Reference proteome.
FT   CHAIN           <1..>295
FT                   /note="Semaphorin-4D"
FT                   /id="PRO_0000176712"
FT   DOMAIN          <1..273
FT                   /note="Sema"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DOMAIN          275..>295
FT                   /note="PSI"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        205
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        30..143
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DISULFID        54..99
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   DISULFID        276..293
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   NON_TER         1
FT   NON_TER         295
SQ   SEQUENCE   295 AA;  33525 MW;  298A49414C352F0A CRC64;
     DDKIYFFFTE VSVEYEFVGK LMIPRIARVC KRDQGGLRTL QKKWTSFLKA RLICTIPDKN
     LIFNIINDVF TLKSPTLKEP VIYGVFTPQL NNVGLSAVCA YNLSAVEEVF SKGKYMQSAT
     VEQSHTKWVR YNGEIPNPRP GACINNEARA LNYVTSLNLP DKTLQFVKDH PLMDDSVTPV
     GDRPRLVKRD VKYTQIVVDR VRALNGTIYD VMFISTDQGA LHKAISYENG MHIIEETQLF
     PKFEPVQTLL LSSKKSRRYL YAGSNSGVVQ SPVAFCDTYT TCFDCVLARD PYCAW