BGB_DROME
ID BGB_DROME Reviewed; 213 AA.
AC Q24040; Q95TG4; Q9W0B9;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2004, sequence version 3.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Protein big brother;
GN Name=Bgb; ORFNames=CG7959;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=8622696; DOI=10.1128/mcb.16.3.932;
RA Golling G., Li L., Pepling M., Stebbins M., Gergen J.P.;
RT "Drosophila homologs of the proto-oncogene product PEBP2/CBF beta regulate
RT the DNA-binding properties of Runt.";
RL Mol. Cell. Biol. 16:932-942(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- FUNCTION: Regulates the DNA-binding properties of Runt.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CBF-beta family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB03676.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; U22177; AAB03676.1; ALT_INIT; mRNA.
DR EMBL; AE014296; AAF47533.3; -; Genomic_DNA.
DR EMBL; AY058784; AAL14013.1; -; mRNA.
DR RefSeq; NP_477065.3; NM_057717.5.
DR AlphaFoldDB; Q24040; -.
DR SMR; Q24040; -.
DR BioGRID; 63732; 11.
DR DIP; DIP-22891N; -.
DR IntAct; Q24040; 11.
DR STRING; 7227.FBpp0072641; -.
DR PaxDb; Q24040; -.
DR DNASU; 38198; -.
DR EnsemblMetazoa; FBtr0072758; FBpp0072641; FBgn0013753.
DR GeneID; 38198; -.
DR KEGG; dme:Dmel_CG7959; -.
DR CTD; 107447; -.
DR FlyBase; FBgn0013753; Bgb.
DR VEuPathDB; VectorBase:FBgn0013753; -.
DR eggNOG; KOG4785; Eukaryota.
DR GeneTree; ENSGT00390000018132; -.
DR HOGENOM; CLU_074992_0_1_1; -.
DR InParanoid; Q24040; -.
DR OMA; CCEGHTE; -.
DR OrthoDB; 1254153at2759; -.
DR PhylomeDB; Q24040; -.
DR Reactome; R-DME-8878166; Transcriptional regulation by RUNX2.
DR Reactome; R-DME-8931987; RUNX1 regulates estrogen receptor mediated transcription.
DR Reactome; R-DME-8934593; Regulation of RUNX1 Expression and Activity.
DR Reactome; R-DME-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR Reactome; R-DME-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR Reactome; R-DME-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
DR Reactome; R-DME-8939245; RUNX1 regulates transcription of genes involved in BCR signaling.
DR Reactome; R-DME-8939246; RUNX1 regulates transcription of genes involved in differentiation of myeloid cells.
DR Reactome; R-DME-8939247; RUNX1 regulates transcription of genes involved in interleukin signaling.
DR Reactome; R-DME-8941326; RUNX2 regulates bone development.
DR Reactome; R-DME-8941858; Regulation of RUNX3 expression and activity.
DR Reactome; R-DME-8951936; RUNX3 regulates p14-ARF.
DR Reactome; R-DME-9018519; Estrogen-dependent gene expression.
DR SignaLink; Q24040; -.
DR BioGRID-ORCS; 38198; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 38198; -.
DR PRO; PR:Q24040; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0013753; Expressed in eye disc (Drosophila) and 29 other tissues.
DR ExpressionAtlas; Q24040; baseline and differential.
DR Genevisible; Q24040; DM.
DR GO; GO:0016513; C:core-binding factor complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0003713; F:transcription coactivator activity; IDA:FlyBase.
DR GO; GO:0008134; F:transcription factor binding; TAS:FlyBase.
DR GO; GO:0035206; P:regulation of hemocyte proliferation; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 2.40.250.10; -; 1.
DR InterPro; IPR003417; CBF_beta.
DR InterPro; IPR036552; CBF_bsu_sf.
DR PANTHER; PTHR10276; PTHR10276; 1.
DR Pfam; PF02312; CBF_beta; 1.
DR SUPFAM; SSF50723; SSF50723; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome.
FT CHAIN 1..213
FT /note="Protein big brother"
FT /id="PRO_0000064920"
FT CONFLICT 8
FT /note="A -> S (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 24
FT /note="P -> K (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 141
FT /note="E -> D (in Ref. 1; AAB03676)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 213 AA; 25177 MW; 6FC6156136B362AA CRC64;
MMNEAALANM IPYDTIGLYE QPKPRFIFKM PRVVPDQKSK FESDELFRRL SRESEVRYTG
YRERSIEERQ VRFMNGCREG HTEASFVASG TNLQLVFNAN QNPYLHDKEC DFDKEHGKVH
IKSYFIMNGV CVRFRGWIDL ERLDGVGCLE YDERRAMHED AILRDQIDRY NQRLREFEDT
KRAYRDNRQD EMEAVRRGVA SGGIGVGASM WRR
