ID   SEMA_VACCW              Reviewed;         295 AA.
AC   P24764; Q80HU1;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Semaphorin-like protein A39;
GN   OrderedLocusNames=VACWR163; ORFNames=A39R;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1856205; DOI=10.1016/s0021-9258(18)92757-2;
RA   Amegadzie B.Y., Ahn B.-Y., Moss B.;
RT   "Identification, sequence, and expression of the gene encoding a Mr 35,000
RT   subunit of the vaccinia virus DNA-dependent RNA polymerase.";
RL   J. Biol. Chem. 266:13712-13718(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2045793; DOI=10.1099/0022-1317-72-6-1349;
RA   Smith G.L., Chan Y.S., Howard S.T.;
RT   "Nucleotide sequence of 42 kbp of vaccinia virus strain WR from near the
RT   right inverted terminal repeat.";
RL   J. Gen. Virol. 72:1349-1376(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- MISCELLANEOUS: In the Western Reserve strain (WR), the A39R protein is
CC       intracellular and not secreted as observed in other vaccinia strains
CC       such as Copenhagen strain (COP). The WR equivalent of the semaphorin-
CC       like protein is split into two ORFs which are likely to be truncated
CC       and non-functional. This ORF would be the N-terminal part.
CC   -!- SIMILARITY: Belongs to the semaphorin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA48335.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAA01811.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAA40587.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; M61187; AAA48335.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; D11079; BAA01811.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; X57318; CAA40587.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AY243312; AAO89442.1; -; Genomic_DNA.
DR   PIR; JQ1775; JQ1775.
DR   PIR; S29921; S29921.
DR   RefSeq; YP_233045.1; NC_006998.1.
DR   SMR; P24764; -.
DR   DIP; DIP-2177N; -.
DR   IntAct; P24764; 1.
DR   MINT; P24764; -.
DR   DNASU; 3707693; -.
DR   GeneID; 3707693; -.
DR   KEGG; vg:3707693; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..295
FT                   /note="Semaphorin-like protein A39"
FT                   /id="PRO_0000099328"
FT   DOMAIN          1..295
FT                   /note="Sema"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00352"
FT   CONFLICT        96..98
FT                   /note="ANT -> TNN (in Ref. 1; CAA40587/AAA48335 and 2;
FT                   BAA01811)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        290..294
FT                   /note="HYVPI -> YSKSA (in Ref. 1; CAA40587/AAA48335 and 2;
FT                   BAA01811)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   295 AA;  33657 MW;  2A9E6FB7A9645B7C CRC64;
     MMVLLHAVYS IVFVDVIIIK VQRYINDILT LDIFYLFKMI PLLFILFYFA NGIEWHKFET
     SEEIISTYLL DDVLYTGVNG AVYTFSNNKL NKTGLANTNY ITTSIKVEDA DKDTLVCGTN
     NGNPKCWKID GSDDPKHRGR GYAPYQNSKV TIISHNGCVL SDINISKEGI KRWRRFDGPC
     GYDLYTADNV IPKDGLRGAF VDKDGTYDKV YILFTDTIGS KRIVKIPYIA QMCLNDEGGP
     SSLSSHRWST FLKVELECDI DGRSYRQIIH SRTIKTDNDT ILYVFFDSPH YVPIL