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SEMG2_HYLKL
ID   SEMG2_HYLKL             Reviewed;         522 AA.
AC   Q6X2M3;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Semenogelin-2;
DE   AltName: Full=Semenogelin II;
DE            Short=SGII;
DE   Flags: Precursor;
GN   Name=SEMG2;
OS   Hylobates klossii (Kloss's gibbon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Hylobates.
OX   NCBI_TaxID=9587;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=14629036; DOI=10.1007/s00239-003-2474-x;
RA   Jensen-Seaman M.I., Li W.-H.;
RT   "Evolution of the hominoid semenogelin genes, the major proteins of
RT   ejaculated semen.";
RL   J. Mol. Evol. 57:261-270(2003).
CC   -!- FUNCTION: Participates in the formation of a gel matrix (sperm
CC       coagulum) entrapping the accessory gland secretions and ejaculated
CC       spermatozoa. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SERPINA5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the semenogelin family. {ECO:0000305}.
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DR   EMBL; AY259291; AAP86629.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6X2M3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050817; P:coagulation; IEA:InterPro.
DR   GO; GO:1901318; P:negative regulation of flagellated sperm motility; IEA:InterPro.
DR   InterPro; IPR008836; Semenogelin.
DR   Pfam; PF05474; Semenogelin; 2.
PE   3: Inferred from homology;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..522
FT                   /note="Semenogelin-2"
FT                   /id="PRO_0000032360"
FT   REGION          26..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..522
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..158
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..307
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..358
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..410
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        411..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        469..513
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   522 AA;  59027 MW;  CEBDF15E3359E1D7 CRC64;
     MKSIILFVLS LLLILEKQAA VMGQKCGSKG QLPSGSSQFP RGQKGQHYSG QKDEQHTKSK
     GSFSIQHTYH VDINDHDRTQ KSQQYDLNAQ HKMTKSKQHL GGSQELLNYK QEGRDHDKSK
     DHFHMIVIHH KGGQAHRGTQ NPSQDQGNSP SGKGISSQYS NTEKRLWVHG LTKEQASASG
     AQKGRTQGGS QSSYVLQTEE LVANKQQRET QNSPQNKGHY QNVVEMREEH SSKLQTSLHP
     AYQDRLQHGP KDIFTTQDEL LVYNKNQHQT KNLNQDQEHG QKTHKISYQS SRTEERQLNR
     GEKSVQKDVS KGGISIQTEE KIHGKSQNQV TIHSQGQEHG HKENKMSYQS SSTEERHLNC
     GEKGIHKGVS KGSISIQTEE QIHGKSQNQV RIPSQAQEHG HKENKMSYQS SSTEERRLNY
     GGKSMQKDVS QSSTSFHTEK LVEGKSQIQT PNPNQDQWSV QNAKGKSDQS AGREQDLLSH
     EQKGRHQQES SEARNIVITE HEVAYDDHLT QQYNEDRNPV ST
 
 
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