ID   SEMG2_HYLLA             Reviewed;         582 AA.
AC   Q5U7N1;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Semenogelin-2;
DE   AltName: Full=Semenogelin II;
DE            Short=SGII;
DE   Flags: Precursor;
GN   Name=SEMG2;
OS   Hylobates lar (Common gibbon) (White-handed gibbon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Hylobates.
OX   NCBI_TaxID=9580;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15531881; DOI=10.1038/ng1471;
RA   Dorus S., Evans P.D., Wyckoff G.J., Choi S.S., Lahn B.T.;
RT   "Rate of molecular evolution of the seminal protein gene SEMG2 correlates
RT   with levels of female promiscuity.";
RL   Nat. Genet. 36:1326-1329(2004).
CC   -!- FUNCTION: Participates in the formation of a gel matrix (sperm
CC       coagulum) entrapping the accessory gland secretions and ejaculated
CC       spermatozoa. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SERPINA5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the semenogelin family. {ECO:0000305}.
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DR   EMBL; AY781389; AAV51947.1; -; mRNA.
DR   AlphaFoldDB; Q5U7N1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050817; P:coagulation; IEA:InterPro.
DR   GO; GO:1901318; P:negative regulation of flagellated sperm motility; IEA:InterPro.
DR   InterPro; IPR008836; Semenogelin.
DR   Pfam; PF05474; Semenogelin; 1.
PE   2: Evidence at transcript level;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..582
FT                   /note="Semenogelin-2"
FT                   /id="PRO_0000032361"
FT   REGION          26..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          132..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..295
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          318..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..417
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          439..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..295
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..358
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..417
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..470
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..528
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        529..573
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   582 AA;  65665 MW;  F8EA07771F9EB40B CRC64;
     MKSIILFVLS LLLILEKQAA VMGQKCGSKG QLPSGSSQFP RGQKGQHYSG QKDEQHTKSK
     GSFSIQHTYH VDVNDRDRTQ KSQQYDLNAQ HKMTKSKQHL GGSQELLNYK QEGRDHDKSK
     DHFHMIVIHH KGGQAHRGTQ NPSQDQGNSP SGKGISSQYS NTNKRLWVHG LTKEQASASG
     AQKGRTQGGS QSSYVLQTEE LVANKQQRET QNSPQNKGHY QNVVEMREEH SSKLQTSLHP
     AYQDRLQHGP KDIFTTQDEL LVYNKNQHQT KNLNQDQEHG QKTHKISYQS SRTEERQLNC
     GEKSVQKDVS KGGISIQTEE KIHGKSQNQV TIHSQGQEHG HKENKMSYQS SSTEERHLNC
     GEKGIHKGVS KGSISIQTEE QIHGKSQNQV RIPSQAQEHG HKENKMSYQS SSTEERRLNC
     GEKGIHKGVS KGSISIQTEE QIHGKSQNQV RIPSQAQEHG HKENKMSYQS SSTEERRLNY
     GGKSMQKDVS QSSTSFHTEK LVEGKSQIQT PNPNQDQWSV QNAKGKSDQS AGREQDLLSH
     EQKGRHQQES SEARNIVITE HEVAYDDHLT QQYNEDRNPV ST