ID   SEMG2_MACFA             Reviewed;         582 AA.
AC   Q5U7N0;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   23-FEB-2022, entry version 42.
DE   RecName: Full=Semenogelin-2;
DE   AltName: Full=Semenogelin II;
DE            Short=SGII;
DE   Flags: Precursor;
GN   Name=SEMG2;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15531881; DOI=10.1038/ng1471;
RA   Dorus S., Evans P.D., Wyckoff G.J., Choi S.S., Lahn B.T.;
RT   "Rate of molecular evolution of the seminal protein gene SEMG2 correlates
RT   with levels of female promiscuity.";
RL   Nat. Genet. 36:1326-1329(2004).
CC   -!- FUNCTION: Participates in the formation of a gel matrix (sperm
CC       coagulum) entrapping the accessory gland secretions and ejaculated
CC       spermatozoa. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SERPINA5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the semenogelin family. {ECO:0000305}.
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DR   EMBL; AY781390; AAV51948.1; -; mRNA.
DR   eggNOG; ENOG502T80H; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050817; P:coagulation; IEA:InterPro.
DR   GO; GO:1901318; P:negative regulation of flagellated sperm motility; IEA:InterPro.
DR   InterPro; IPR008836; Semenogelin.
DR   Pfam; PF05474; Semenogelin; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..582
FT                   /note="Semenogelin-2"
FT                   /id="PRO_0000032362"
FT   REGION          25..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..553
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        94..131
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..307
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..362
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        370..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        410..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        470..528
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        529..543
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   582 AA;  65754 MW;  20E56C568FF69CBE CRC64;
     MKSIILFVLS LLLILEKQAA VMGQKGGSKG QLSSGSSRFP HRHRSQHYSG QKDKQHTESK
     GSFSIQHTYH VDANDHDRTR KSQQYYLNAQ HKTTKSKQHL RRHQRLLNYK QKGRGRVKPK
     RHFHLIVIHR KGGQVHHGTQ NPSQDQGNSP SGKGISSQYS NTEERLRVRG LSKEQASASG
     AQKGRTQGGS QTNYVLQTEE LVANKQQRET QNSHRNKGHY QNVVDVRXEH SSKLQTSLRP
     AHQHKLQHGY KDIFTTQDEL LVYNKNQHQT KNLNQDQEHG RKAHKGSYQS SSTEERQPNH
     EEKSVQKGVP KGSISIQTEE KIYGKSQNQV TIPSQDQEHG HKENKISYQS SSAEERRLNS
     GEKGIQKGVS KGSISIQTEE KIHGKSQNQV AIPSQDQEHG HKENKISYQS SSAEERQLNS
     GEKGIQKGVS KGSISIQTEE KIYGKSQNQV TIPSQDQEHG HKENKIAYQS SSTEERQLNY
     GGKSIQKDVS QSSLSFQTEK LVEGKSQIQT PNPNQGQWSG QNAKGNSGKS ADRKQDLLSH
     EQEGRYQQEF SGAHNTVNIE HKVAYDDLLT QQYNEDRNPI ST