ID   SEMG2_MACMU             Reviewed;         706 AA.
AC   Q95196;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Semenogelin-2;
DE   AltName: Full=Semenogelin II;
DE            Short=SGII;
DE   Flags: Precursor;
GN   Name=SEMG2;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9128720; DOI=10.1111/j.1432-1033.1997.00025.x;
RA   Ulvsbaeck M., Lundwall A.;
RT   "Cloning of the semenogelin II gene of the rhesus monkey. Duplications of
RT   360 bp extend the coding region in man, rhesus monkey and baboon.";
RL   Eur. J. Biochem. 245:25-31(1997).
CC   -!- FUNCTION: Participates in the formation of a gel matrix (sperm
CC       coagulum) entrapping the accessory gland secretions and ejaculated
CC       spermatozoa.
CC   -!- SUBUNIT: Interacts with SERPINA5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the semenogelin family. {ECO:0000305}.
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DR   EMBL; X92589; CAA63333.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q95196; -.
DR   STRING; 9544.ENSMMUP00000023119; -.
DR   eggNOG; ENOG502T80H; Eukaryota.
DR   InParanoid; Q95196; -.
DR   Proteomes; UP000006718; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050817; P:coagulation; IEA:InterPro.
DR   GO; GO:1901318; P:negative regulation of flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0048240; P:sperm capacitation; IBA:GO_Central.
DR   InterPro; IPR008836; Semenogelin.
DR   Pfam; PF05474; Semenogelin; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..706
FT                   /note="Semenogelin-2"
FT                   /id="PRO_0000032363"
FT   REGION          25..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          131..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..339
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        340..366
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..399
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        400..426
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..459
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..486
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        494..519
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        534..579
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        594..652
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        653..667
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   706 AA;  79875 MW;  F9ADB15CCFDA6A6F CRC64;
     MKSIILFVLS LLLILEKQAA VMGQKGGSKG QLSSGSSRFP HRHRSQHYSG QKDKQHTESK
     GSFSIQHTYH VDANDHDRTR KSQQYYLNAQ HKTTKSKQHL RRRQRLLNYK QKGRGRVKPK
     RHFHLIVIHR KGGQVHHGTQ NPSQDQGNSP SGKGIFRQYS NTEERLWFRG LSKEQASASG
     AQKGRTQGGS QTNYVLQTEE LVANKQQNKQ QRETQNSHRN KGHYQNVFEV REEHSSKLQT
     SLHPAHQHRL QHGYKDIFTT QNELLVYNKN QHQTKNLNQD QEHGQKAHKG SYQSSSTEER
     QPNHEENSVQ KGVPKGSISI QTEEKIYGKS QNQVTIPSQD QEHGHKENKI SYQSSSAEER
     RLNSGEKGIQ KGVPKGSISI QTEEKIYGKS QNQVTIPSQD QEHGHKENKI SYQSSSAEER
     RLNSGEKGIQ KGVPKGSISI QTEEKIYGKS QNQVTIPSQD QEHGHKENKI SYQSSSTEER
     RLNSGEKGIQ RGVSKGSISI QTEEKIHGKS QNQVAIPSQD QEHGHKENKI SYQSSSAEER
     QLNSGEKGIQ KGVSKGSISI QTEEKIYGKS QNQVTIPSQD QEHGHKENKI AYQSSSTEER
     QLNYGGKSIQ KDVSQSSLSF QTEKLVEGKS QIQTPNPNQG QWSGQNAKGN SGKSADREQD
     LLSHEQEGRY QQEFSGAHNT VNIEHEVAYD DLLTQQYNED RNPVST