SEMG2_MACNE
ID SEMG2_MACNE Reviewed; 582 AA.
AC Q5U7M9;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Semenogelin-2;
DE AltName: Full=Semenogelin II;
DE Short=SGII;
DE Flags: Precursor;
GN Name=SEMG2;
OS Macaca nemestrina (Pig-tailed macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9545;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15531881; DOI=10.1038/ng1471;
RA Dorus S., Evans P.D., Wyckoff G.J., Choi S.S., Lahn B.T.;
RT "Rate of molecular evolution of the seminal protein gene SEMG2 correlates
RT with levels of female promiscuity.";
RL Nat. Genet. 36:1326-1329(2004).
CC -!- FUNCTION: Participates in the formation of a gel matrix (sperm
CC coagulum) entrapping the accessory gland secretions and ejaculated
CC spermatozoa. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SERPINA5. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the semenogelin family. {ECO:0000305}.
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DR EMBL; AY781391; AAV51949.1; -; mRNA.
DR RefSeq; NP_001295937.1; NM_001309008.1.
DR GeneID; 105496431; -.
DR CTD; 6407; -.
DR OrthoDB; 305064at2759; -.
DR Proteomes; UP000233120; Whole Genome Shotgun Assembly.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0050817; P:coagulation; IEA:InterPro.
DR GO; GO:1901318; P:negative regulation of flagellated sperm motility; IEA:InterPro.
DR InterPro; IPR008836; Semenogelin.
DR Pfam; PF05474; Semenogelin; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..582
FT /note="Semenogelin-2"
FT /id="PRO_0000032364"
FT REGION 25..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 129..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 445..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..307
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..335
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..422
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 582 AA; 65976 MW; 06740D4DCDAD393E CRC64;
MKSIILFVLS LLLILEKQAA VMGQKGGSKG QLSSGSSRFP HRHRSQHYSG QKDKQHTESK
GSFSIQHTYH VDANDHDRTR KSQQYYLNAQ HKTTKSKQHL RRRQRLLNYK QKGRGRVKPK
RHFHLIVIHR KGGQVHHGTQ NPSQDQGNSP SGKGIFRQYS NTEKRLWVHG LSKEQASASG
AQKGRTQGGS QSSYVLQTEE LVVNKQQLET KNSHQNKGHY QNVVDVREEH SGKLQTSLHP
AHQDRLQHGP KDIFTTQDEL LVYNKNQHQT KNLNQDQEHG QKAHKISYQS SRTEERQLNH
GEKSVQKDVS KGSISIQTEE KIHGKSQNQV TIPSQDQEHG HKENKISYQS SSAEERRLNS
GEKGIQKGVX KGSISIQTEE KIYGKSQNQV TIPSQDQEHG HKENKISYQS SSAEERRLNS
GEKGIQKGVX KGSISIQTEE KIYGKSQNQV TIPSQDQEHG HKENKISYQS SSTEQRQLNY
GRKSIQKDVI QSSLSFQTEK LVEGKSQIQT PNPNQGQWSG QNAKGNSGKS ADGEQDLLSH
EQEGRYQQEF SGAHNTVNIE HEVAYDDLLT QQYNEDRNPI ST