ID   SEMG2_PANTR             Reviewed;         407 AA.
AC   Q5U7N4; A4K2P3;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Semenogelin-2;
DE   AltName: Full=Semenogelin II;
DE            Short=SGII;
DE   Flags: Precursor;
GN   Name=SEMG2;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15531881; DOI=10.1038/ng1471;
RA   Dorus S., Evans P.D., Wyckoff G.J., Choi S.S., Lahn B.T.;
RT   "Rate of molecular evolution of the seminal protein gene SEMG2 correlates
RT   with levels of female promiscuity.";
RL   Nat. Genet. 36:1326-1329(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=17267810; DOI=10.1101/gr.6004607;
RG   NISC comparative sequencing program;
RA   Hurle B., Swanson W., Green E.D.;
RT   "Comparative sequence analyses reveal rapid and divergent evolutionary
RT   changes of the WFDC locus in the primate lineage.";
RL   Genome Res. 17:276-286(2007).
CC   -!- FUNCTION: Participates in the formation of a gel matrix (sperm
CC       coagulum) entrapping the accessory gland secretions and ejaculated
CC       spermatozoa. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SERPINA5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the semenogelin family. {ECO:0000305}.
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DR   EMBL; AY781386; AAV51944.1; -; mRNA.
DR   EMBL; DP000037; ABO52928.1; -; Genomic_DNA.
DR   RefSeq; NP_001009138.1; NM_001009138.1.
DR   STRING; 9598.ENSPTRP00000054529; -.
DR   GeneID; 493189; -.
DR   KEGG; ptr:493189; -.
DR   CTD; 6407; -.
DR   InParanoid; Q5U7N4; -.
DR   OrthoDB; 305064at2759; -.
DR   Proteomes; UP000002277; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0050817; P:coagulation; IEA:InterPro.
DR   GO; GO:1901318; P:negative regulation of flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0048240; P:sperm capacitation; IBA:GO_Central.
DR   InterPro; IPR008836; Semenogelin.
DR   Pfam; PF05474; Semenogelin; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Repeat; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..407
FT                   /note="Semenogelin-2"
FT                   /id="PRO_0000032365"
FT   REGION          25..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          96..193
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..407
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        110..127
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        136..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        275..307
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        335..362
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        370..394
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        12
FT                   /note="V -> L (in Ref. 2; ABO52928)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   407 AA;  45812 MW;  EB0BCBA06D74D529 CRC64;
     MKSIILFVLS LVLILEKQAA VMGQKDGSKG QLPSGSSQFP HGQKGQHYFG QKDQQHTKSK
     GSFSIQHTYH VDINDHDQTR KSQQYDLNAL HKVTKSKQHL DGSQQLLNYK QEGRDHDKSE
     GHFHMIVIHH KGGQAHCGTQ NPSQDQGNSP SGKGLSSQYS NTEKRLWVHG LSKEQASASG
     AQKGRTQGGS QSSYVLQTEE LVVNKQQLET KNSHQNKGHY QNVVDVREEH SGKLQTSLHP
     AHQDRLQHGP KDIFTTQDEL LVYNKNQHQT KNLNQDQEHG QKAHKISYQS SRTEERQLNH
     GEKSVQKDVS KGSISIQTEE KIHGKSQNQV TIHSQDQEHG HKENKMSYQS SSTEERHLNC
     GEKGIQKGVS KGSISIQTEE QIHGKSQNXV RIPSQAQEYG RKENKIS