ID   SEML_HUMAN              Reviewed;         128 AA.
AC   Q6ZVN7;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Putative protein SEM1, isoform 2 {ECO:0000312|HGNC:HGNC:10845};
GN   Name=SEM1 {ECO:0000312|HGNC:HGNC:10845}; Synonyms=C7orf76;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative promoter usage; Named isoforms=2;
CC       Name=2;
CC         IsoId=Q6ZVN7-1; Sequence=Displayed;
CC       Name=1;
CC         IsoId=P60896-1; Sequence=External;
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DR   EMBL; AK124274; BAC85824.1; -; mRNA.
DR   EMBL; AC092031; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001188379.1; NM_001201450.1.
DR   RefSeq; NP_001188380.1; NM_001201451.1.
DR   AlphaFoldDB; Q6ZVN7; -.
DR   STRING; 9606.ENSP00000481021; -.
DR   BioMuta; SEM1; -.
DR   PaxDb; Q6ZVN7; -.
DR   PRIDE; Q6ZVN7; -.
DR   Antibodypedia; 30181; 152 antibodies from 27 providers.
DR   Ensembl; ENST00000356686.2; ENSP00000349114.1; ENSG00000127922.10. [Q6ZVN7-1]
DR   UCSC; uc064fom.1; human. [Q6ZVN7-1]
DR   GeneCards; SEM1; -.
DR   HGNC; HGNC:10845; SEM1.
DR   HPA; ENSG00000127922; Low tissue specificity.
DR   MalaCards; SEM1; -.
DR   neXtProt; NX_Q6ZVN7; -.
DR   OpenTargets; ENSG00000127922; -.
DR   VEuPathDB; HostDB:ENSG00000127922; -.
DR   eggNOG; ENOG502TE1I; Eukaryota.
DR   GeneTree; ENSGT00940000162732; -.
DR   HOGENOM; CLU_2009139_0_0_1; -.
DR   InParanoid; Q6ZVN7; -.
DR   OrthoDB; 1474875at2759; -.
DR   PhylomeDB; Q6ZVN7; -.
DR   PathwayCommons; Q6ZVN7; -.
DR   SignaLink; Q6ZVN7; -.
DR   BioGRID-ORCS; 7979; 665 hits in 1077 CRISPR screens.
DR   ChiTaRS; SHFM1; human.
DR   GenomeRNAi; 7979; -.
DR   Pharos; Q6ZVN7; Tbio.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q6ZVN7; protein.
DR   Bgee; ENSG00000127922; Expressed in calcaneal tendon and 202 other tissues.
DR   ExpressionAtlas; Q6ZVN7; baseline and differential.
DR   GO; GO:0000502; C:proteasome complex; IBA:GO_Central.
DR   GO; GO:0008541; C:proteasome regulatory particle, lid subcomplex; IEA:InterPro.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0006406; P:mRNA export from nucleus; IEA:InterPro.
DR   GO; GO:0043248; P:proteasome assembly; IEA:InterPro.
DR   InterPro; IPR007834; DSS1_SEM1.
DR   InterPro; IPR041319; DUF5543.
DR   PANTHER; PTHR16771; PTHR16771; 1.
DR   Pfam; PF17697; DUF5543; 1.
PE   2: Evidence at transcript level;
KW   Alternative promoter usage; Reference proteome.
FT   CHAIN           1..128
FT                   /note="Putative protein SEM1, isoform 2"
FT                   /id="PRO_0000319035"
FT   REGION          22..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        86
FT                   /note="R -> G (in Ref. 1; BAC85824)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   128 AA;  14085 MW;  168AB7945F5ADAB8 CRC64;
     MYCQDSNICA VFAVQGGKVG RKHGIKRGRR PSIRSPAQRA RGPWIHESKH PAFAKQQINL
     EMPNSRATTE LAWVCSSTSR KKKWARSLTL STAPLSPPPS LVHCEDCSCL PGCHSGDLYN
     LAPAERTC