SEN15_ASHGO
ID SEN15_ASHGO Reviewed; 118 AA.
AC Q759Y8;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=tRNA-splicing endonuclease subunit SEN15;
DE AltName: Full=tRNA-intron endonuclease SEN15;
GN Name=SEN15; OrderedLocusNames=ADR135W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Non-catalytic subunit of the tRNA-splicing endonuclease
CC complex, a complex responsible for identification and cleavage of the
CC splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice
CC sites to release the intron. The products are an intron and two tRNA
CC half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There
CC are no conserved sequences at the splice sites, but the intron is
CC invariably located at the same site in the gene, placing the splice
CC sites an invariant distance from the constant structural features of
CC the tRNA body (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: tRNA splicing endonuclease is a heterotetramer composed of
CC SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN34 (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SEN15 family. {ECO:0000305}.
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DR EMBL; AE016817; AAS52055.1; -; Genomic_DNA.
DR RefSeq; NP_984231.1; NM_209584.1.
DR AlphaFoldDB; Q759Y8; -.
DR SMR; Q759Y8; -.
DR STRING; 33169.AAS52055; -.
DR PRIDE; Q759Y8; -.
DR EnsemblFungi; AAS52055; AAS52055; AGOS_ADR135W.
DR GeneID; 4620392; -.
DR KEGG; ago:AGOS_ADR135W; -.
DR eggNOG; ENOG502SC4F; Eukaryota.
DR HOGENOM; CLU_083361_2_0_1; -.
DR InParanoid; Q759Y8; -.
DR OMA; VYYFVYK; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0000214; C:tRNA-intron endonuclease complex; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000213; F:tRNA-intron endonuclease activity; IEA:EnsemblFungi.
DR GO; GO:0000379; P:tRNA-type intron splice site recognition and cleavage; IBA:GO_Central.
DR Gene3D; 3.40.1350.10; -; 1.
DR InterPro; IPR042777; Sen15_fungi.
DR InterPro; IPR018593; tRNA-endonuc_su_Sen15.
DR InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR InterPro; IPR036167; tRNA_intron_Endo_cat-like_sf.
DR PANTHER; PTHR28518; PTHR28518; 1.
DR Pfam; PF09631; Sen15; 1.
DR SUPFAM; SSF53032; SSF53032; 1.
PE 3: Inferred from homology;
KW Reference proteome; tRNA processing.
FT CHAIN 1..118
FT /note="tRNA-splicing endonuclease subunit SEN15"
FT /id="PRO_0000194025"
SQ SEQUENCE 118 AA; 13189 MW; A26BF4543BB414D8 CRC64;
MSVSYNGGLT GLTALVRNNL VHYQQWSDVE VVPLRDREAL RGRPAQKLSN DDEEIGVEYV
LPVELSQYRS SGVTLEALDK VFSQLPASCK RVVLAISSDD GTVVYYTVYQ GLQRPRKN
