ID   SEN15_SCHPO             Reviewed;         143 AA.
AC   Q7LKV3;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Probable tRNA-splicing endonuclease subunit sen15;
DE   AltName: Full=tRNA-intron endonuclease sen15;
GN   Name=sen15; ORFNames=SPAC959.10;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Non-catalytic subunit of the tRNA-splicing endonuclease
CC       complex, a complex responsible for identification and cleavage of the
CC       splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice
CC       sites to release the intron. The products are an intron and two tRNA
CC       half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There
CC       are no conserved sequences at the splice sites, but the intron is
CC       invariably located at the same site in the gene, placing the splice
CC       sites an invariant distance from the constant structural features of
CC       the tRNA body (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: tRNA splicing endonuclease is a heterotetramer composed of
CC       sen2, sen15, sen34 and sen54. Interacts directly with sen34 (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SEN15 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAE46913.1; -; Genomic_DNA.
DR   RefSeq; NP_001018260.1; NM_001019595.2.
DR   AlphaFoldDB; Q7LKV3; -.
DR   SMR; Q7LKV3; -.
DR   BioGRID; 280542; 4.
DR   STRING; 4896.SPAC959.10.1; -.
DR   MaxQB; Q7LKV3; -.
DR   PaxDb; Q7LKV3; -.
DR   EnsemblFungi; SPAC959.10.1; SPAC959.10.1:pep; SPAC959.10.
DR   GeneID; 3361466; -.
DR   KEGG; spo:SPAC959.10; -.
DR   PomBase; SPAC959.10; sen15.
DR   VEuPathDB; FungiDB:SPAC959.10; -.
DR   eggNOG; ENOG502SC4F; Eukaryota.
DR   HOGENOM; CLU_083361_2_0_1; -.
DR   InParanoid; Q7LKV3; -.
DR   OMA; QWDELKI; -.
DR   PhylomeDB; Q7LKV3; -.
DR   PRO; PR:Q7LKV3; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0000214; C:tRNA-intron endonuclease complex; ISO:PomBase.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0090502; P:RNA phosphodiester bond hydrolysis, endonucleolytic; IEA:GOC.
DR   GO; GO:0000379; P:tRNA-type intron splice site recognition and cleavage; ISO:PomBase.
DR   Gene3D; 3.40.1350.10; -; 1.
DR   InterPro; IPR042777; Sen15_fungi.
DR   InterPro; IPR018593; tRNA-endonuc_su_Sen15.
DR   InterPro; IPR011856; tRNA_endonuc-like_dom_sf.
DR   InterPro; IPR036167; tRNA_intron_Endo_cat-like_sf.
DR   PANTHER; PTHR28518; PTHR28518; 1.
DR   Pfam; PF09631; Sen15; 1.
DR   SUPFAM; SSF53032; SSF53032; 1.
PE   3: Inferred from homology;
KW   Reference proteome; tRNA processing.
FT   CHAIN           1..143
FT                   /note="Probable tRNA-splicing endonuclease subunit sen15"
FT                   /id="PRO_0000194027"
SQ   SEQUENCE   143 AA;  16467 MW;  4B96D12DCD5FB696 CRC64;
     MQHNTFLPND AVEEQKQNPY YGILRAVETD LRLGQRWCEL KVHVLDIDLK TKRPLLSGIP
     VNGQLKDKLQ YVLPLYLQET ISIEFLSSVF DSMKKLSLPL VKDARGLSGD EFFLYLGIMC
     SDSTIVYYKI TDGLIKPRQN DEE