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SEN1_SCHPO
ID   SEN1_SCHPO              Reviewed;        1687 AA.
AC   Q92355;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Helicase sen1;
DE            EC=3.6.4.-;
GN   Name=sen1; ORFNames=SPAC6G9.10c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   PROTEIN SEQUENCE OF 1230-1241 AND 1489-1493, FUNCTION, AND SUBUNIT.
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=10545196; DOI=10.1021/bi991470c;
RA   Kim H.-D., Choe J., Seo Y.-S.;
RT   "The sen1(+) gene of Schizosaccharomyces pombe, a homologue of budding
RT   yeast SEN1, encodes an RNA and DNA helicase.";
RL   Biochemistry 38:14697-14710(1999).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: ATP-dependent 5'->3' DNA/RNA helicase required for the
CC       expression and maturation of diverse classes of non-protein-coding RNAs
CC       like precursor tRNAs, rRNAs and small nuclear (snRNA) and nucleolar
CC       (snoRNA) RNAs. Directs RNA polymerase II transcription termination on
CC       snoRNAs as well as on several short protein-coding genes. May also play
CC       a role in transcription-coupled nucleotide excision repair (By
CC       similarity). {ECO:0000250, ECO:0000269|PubMed:10545196}.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:10545196}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16823372}.
CC   -!- SIMILARITY: Belongs to the DNA2/NAM7 helicase family. {ECO:0000305}.
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DR   EMBL; CU329670; CAB03612.1; -; Genomic_DNA.
DR   PIR; T39072; T39072.
DR   RefSeq; NP_594119.1; NM_001019543.2.
DR   AlphaFoldDB; Q92355; -.
DR   SMR; Q92355; -.
DR   BioGRID; 278055; 36.
DR   STRING; 4896.SPAC6G9.10c.1; -.
DR   iPTMnet; Q92355; -.
DR   MaxQB; Q92355; -.
DR   PaxDb; Q92355; -.
DR   PRIDE; Q92355; -.
DR   EnsemblFungi; SPAC6G9.10c.1; SPAC6G9.10c.1:pep; SPAC6G9.10c.
DR   GeneID; 2541556; -.
DR   KEGG; spo:SPAC6G9.10c; -.
DR   PomBase; SPAC6G9.10c; sen1.
DR   VEuPathDB; FungiDB:SPAC6G9.10c; -.
DR   eggNOG; KOG1801; Eukaryota.
DR   HOGENOM; CLU_000459_2_0_1; -.
DR   InParanoid; Q92355; -.
DR   OMA; MIFMECW; -.
DR   PhylomeDB; Q92355; -.
DR   PRO; PR:Q92355; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0000785; C:chromatin; IDA:PomBase.
DR   GO; GO:0016604; C:nuclear body; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0033678; F:5'-3' DNA/RNA helicase activity; IDA:PomBase.
DR   GO; GO:0032574; F:5'-3' RNA helicase activity; IDA:PomBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0001147; F:transcription termination site sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IBA:GO_Central.
DR   GO; GO:0006386; P:termination of RNA polymerase III transcription; IMP:PomBase.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd18808; SF1_C_Upf1; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR045055; DNA2/NAM7-like.
DR   InterPro; IPR041679; DNA2/NAM7-like_C.
DR   InterPro; IPR041677; DNA2/NAM7_AAA_11.
DR   InterPro; IPR024481; Helicase_Sen1_N.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR026121; Sen1.
DR   PANTHER; PTHR10887; PTHR10887; 1.
DR   PANTHER; PTHR10887:SF487; PTHR10887:SF487; 1.
DR   Pfam; PF13086; AAA_11; 1.
DR   Pfam; PF13087; AAA_12; 1.
DR   Pfam; PF12726; SEN1_N; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Direct protein sequencing; Helicase; Hydrolase;
KW   mRNA processing; Nucleotide-binding; Nucleus; Reference proteome;
KW   rRNA processing; tRNA processing.
FT   CHAIN           1..1687
FT                   /note="Helicase sen1"
FT                   /id="PRO_0000080723"
FT   REGION          781..801
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1661..1687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         1134
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         1155..1159
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         1407
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         1445
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
FT   BINDING         1574
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1687 AA;  192548 MW;  92C82F2049E2680D CRC64;
     MAENLSDQDC FEKLSSSKEG QHWFCSGLLT QYIQPTFFWF AHDETPSFKW VLNAYHERLR
     SCTSCIQAYY ELRNESLAKG SYSFTGFSIT DLQEKWNKWD IIRVLEDFKA LEDETIDFTS
     LPCLIFETLL NPKLFTCKNI YKNAIDAFNG LLSDWCSNIF LPGYLLFFYE ASHPDVLEWV
     HSFFKENTEI RISSATVDAV FNTVVFESQN SSDSDCNFVS ISSPEFWERT YMFLELLPLQ
     SITAACESIL KDYLLNLVKT SESLSSQQMS CLRICCNSSS FWSAADSFKE VSSFLKNLLK
     NVTATPFEVS DMNWAYIIAS FFRTCLNDFV SVFPEWLKGF VEEKRTIGFI IYSVLDALFD
     LLSLDYSSPS FLNNTLSLMN ANSITILQDY PEYMLKLRLH SLLYDIAFIS WSHKAITKNP
     SFVFDPSYEL SPFWKLDNLQ EEKISDVLFS KISSCCFAHD IEISENSTPS GTMVQFAELW
     QVMSEYISGF LKGFSEKSST EISNMLGDSS KFDTVVSFLL SPTQPLYVSA FHIVQIITNC
     TKNRNEALKK LVAMDFRGIV HGLADAVLNW QSILSFFPAL RIMRFLSITN KSLSSDNSAF
     TENDIPTLGA YWQCIWNILD LVFSNVARWS LNNPADTVKA LMKLTLKFVD DLFQNDGIFI
     KLLAKFDSLI LLGETSESLF SFIMWLKIND LELRGIVINS LCKLFTKFSN FDYLFEDRTV
     TFLTDFIIRK QKAHLSADQC KQLANVLTQA SPEAKTVLEQ HRLSEMRKTK KQTELTNSAH
     VIKPSPTPQI TVKQNTTKSS SAPRMGMLEQ LKQEYLTKRN FESKLKSSAV SSRKPTFNEV
     KPANLLAEDL SDNEDDIDRK QGLFSLAKAN KIPEIRQQER RQVQLLSNST IKMHPSQIRM
     MTNRNVANVK ARLFPSMTDF YKEILSWEPA NQSPNPVLKF HKLDGKIIDS FKTVEHYMEV
     LQPMIFMECW SQIQSTKLDL KFSPVEGIMV ERTAVNNFVD IGVSVAPKDL YGYPLYDTEV
     VSLAFNKEDA SSMKGLCCFA KVERIVRQTN GVLVVLRTLP SMEILNKLQG NCALWFLKLT
     NLATFTRQYA GIRGLPYFHL ADDIIRARPC SQPVKHSSSE IKAAMKRYQV NEPQAKAIMC
     ALDNNGFTLI QGPPGTGKTK TIIGIISALL VDLSRYHITR PNQQSKSTES KQQILLCAPS
     NAAVDEVLLR LKRGFLLENG EKYIPRVVRI GNPETINVSV RDLSLEYQTE KQLLEVNQGA
     IDLGSLQELT RWRDTFYDCI QKIEELEKQI DVARDVAEDT KSLGKELQNK INEKNLAEQK
     VEELQSQSFT KNKEVDLLRK KAQKAILKQA DVVCATLSGS GHDLVAHSSL NFSTVIIDEA
     AQAVELDTII PLRYGAKKCI LVGDPNQLPP TVLSKKAASL NYSQSLFVRI QKNFSNQMCL
     LSIQYRMHPD ISHFPSKKFY DSRLEDGDNM AEKTQQVWHV NPKFTQYRLF DVRGKERTSN
     TMSTYNLEEV EYLVNMVDEL LNKFPDVNFT GRIGVITPYR SQLHELRRAF KVKYGKSFMS
     TIDIQTVDGF QGQEKDIIFF SCVKSYSKHG IGFLRDFRRL NVALTRARSS LLIIGNMETL
     KTDDLWGSLV DDALSRKLVE SPHIDSEGRL ITISRTSEKR MKNEEFVEPP SKKLANSEPS
     KEIRQRS
 
 
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