ID   SENP5_MACFA             Reviewed;         755 AA.
AC   Q8WP32;
DT   28-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Sentrin-specific protease 5;
DE            EC=3.4.22.-;
DE   AltName: Full=Sentrin/SUMO-specific protease SENP5;
GN   Name=SENP5; ORFNames=QtsA-16408;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
CC   -!- FUNCTION: Protease that catalyzes two essential functions in the SUMO
CC       pathway: processing of full-length SUMO3 to its mature form and
CC       deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak
CC       proteolytic activity against full-length SUMO1 or SUMO1 conjugates.
CC       Required for cell division. {ECO:0000250|UniProtKB:Q96HI0}.
CC   -!- SUBUNIT: Interacts with CCAR2. {ECO:0000250|UniProtKB:Q96HI0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peptidase C48 family. {ECO:0000305}.
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DR   EMBL; AB074445; BAB72076.1; -; mRNA.
DR   RefSeq; NP_001270238.1; NM_001283309.1.
DR   AlphaFoldDB; Q8WP32; -.
DR   SMR; Q8WP32; -.
DR   STRING; 9541.XP_005545351.1; -.
DR   MEROPS; C48.008; -.
DR   GeneID; 102117667; -.
DR   CTD; 205564; -.
DR   eggNOG; KOG0778; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019783; F:ubiquitin-like protein peptidase activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0016926; P:protein desumoylation; IEA:InterPro.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR003653; Peptidase_C48_C.
DR   InterPro; IPR045577; SENP3_5_cons_dom.
DR   InterPro; IPR033465; SENP5.
DR   PANTHER; PTHR12606:SF10; PTHR12606:SF10; 1.
DR   Pfam; PF02902; Peptidase_C48; 1.
DR   Pfam; PF19722; SENP3_5_N; 1.
DR   SUPFAM; SSF54001; SSF54001; 1.
DR   PROSITE; PS50600; ULP_PROTEASE; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Hydrolase; Nucleus; Protease;
KW   Reference proteome; Thiol protease; Ubl conjugation pathway.
FT   CHAIN           1..755
FT                   /note="Sentrin-specific protease 5"
FT                   /id="PRO_0000101724"
FT   REGION          269..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          563..724
FT                   /note="Protease"
FT   ACT_SITE        646
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        663
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        713
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   755 AA;  86290 MW;  40EC773CA29B8CEA CRC64;
     MKKQRKILWR KGIHLAFSEK WNTGFGGFKK FYFHQHLCIL KAKLGRPITR NRQLRHFQGG
     KKALQIQKTW VKDEPPCAKT KFSVDTPHAS TLSSPVKRKD TKHFVSSSRT LLRLQAEKLL
     SSAKNSDHEY CREKNLLKTV TDFPSNSALG QANGHRPRTD PQASDFPMKF NGESQSPGES
     GAIVITLSNH KRKGFCYGCC RGPEHHRNGG PLIPKQFQLN RHRRIKLSPL MMYEKLSMIR
     FRYRILRSQH FRTKSKVCKL RKAQRSWVQK VTGDHQETLR ENGEGGSGSP FPSPEPKDPS
     CRQQPYFPDM DSNAVVKGTN SHVPDGHTKG SPFLGKELSL DEAFPDQQNG SATHAWDQSS
     CASPKWECTE LIHDIPLPEH HSNTMFVSET EKEIATLGQE NRTSSLSDDG VKLSVSGADT
     SVSSVDGPVS QKAVHSENSY QMEEDGSLKQ NILSSELLDH PYCKSPLEAP LVCSGLKLEN
     QVGGGKDSQK ASPVDDEQLS VCLSGFLDEV MKKYGSLVPL SEKEVLGRLK DVFNEDFSNR
     KPFINREITN YRARHQKCNF RIFYNKHMLD MDDLATLDGQ NWLNDQVINM YGELIMDAVP
     DKVHFFNSFF HRQLVTKGYN GVKRWTKKVD LFKKSLLLIP IHLEVHWSLI TVTLSNRIIS
     FYDSQGIHFK FCVENIRKYL LTEAREKNRP EFLQGWQTAV TKCIPQQKND SDCGVFVLQY
     CKCLALEQPF QFSQEDMPRV RKRIYKELCE CRLMD