SENP8_RAT
ID SENP8_RAT Reviewed; 217 AA.
AC Q5FVJ8;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Sentrin-specific protease 8;
DE EC=3.4.22.-;
DE AltName: Full=Deneddylase-1;
DE AltName: Full=NEDD8-specific protease 1;
DE AltName: Full=Sentrin/SUMO-specific protease SENP8;
GN Name=Senp8;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Protease that catalyzes two essential functions in the NEDD8
CC pathway: processing of full-length NEDD8 to its mature form and
CC deconjugation of NEDD8 from targeted proteins such as cullins or p53.
CC {ECO:0000250|UniProtKB:Q96LD8}.
CC -!- SIMILARITY: Belongs to the peptidase C48 family. {ECO:0000305}.
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DR EMBL; BC089939; AAH89939.1; -; mRNA.
DR RefSeq; NP_001012355.1; NM_001012355.1.
DR AlphaFoldDB; Q5FVJ8; -.
DR SMR; Q5FVJ8; -.
DR STRING; 10116.ENSRNOP00000062239; -.
DR PhosphoSitePlus; Q5FVJ8; -.
DR PaxDb; Q5FVJ8; -.
DR Ensembl; ENSRNOT00000015415; ENSRNOP00000062239; ENSRNOG00000011595.
DR Ensembl; ENSRNOT00000095899; ENSRNOP00000086291; ENSRNOG00000011595.
DR Ensembl; ENSRNOT00000111287; ENSRNOP00000086922; ENSRNOG00000011595.
DR Ensembl; ENSRNOT00000117148; ENSRNOP00000093886; ENSRNOG00000011595.
DR Ensembl; ENSRNOT00000117798; ENSRNOP00000076855; ENSRNOG00000011595.
DR GeneID; 315723; -.
DR KEGG; rno:315723; -.
DR UCSC; RGD:1309955; rat.
DR CTD; 123228; -.
DR RGD; 1309955; Senp8.
DR eggNOG; KOG3246; Eukaryota.
DR GeneTree; ENSGT00390000014038; -.
DR HOGENOM; CLU_043678_3_1_1; -.
DR InParanoid; Q5FVJ8; -.
DR OMA; LLDPPNW; -.
DR OrthoDB; 1313098at2759; -.
DR PhylomeDB; Q5FVJ8; -.
DR TreeFam; TF351057; -.
DR PRO; PR:Q5FVJ8; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000011595; Expressed in skeletal muscle tissue and 19 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016929; F:deSUMOylase activity; IBA:GO_Central.
DR GO; GO:0016926; P:protein desumoylation; IBA:GO_Central.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR003653; Peptidase_C48_C.
DR Pfam; PF02902; Peptidase_C48; 1.
DR SUPFAM; SSF54001; SSF54001; 1.
DR PROSITE; PS50600; ULP_PROTEASE; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Hydrolase; Protease; Reference proteome; Thiol protease;
KW Ubl conjugation pathway.
FT CHAIN 1..217
FT /note="Sentrin-specific protease 8"
FT /id="PRO_0000101729"
FT REGION 11..174
FT /note="Protease"
FT ACT_SITE 102
FT /evidence="ECO:0000250"
FT ACT_SITE 119
FT /evidence="ECO:0000250"
FT ACT_SITE 163
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q96LD8"
SQ SEQUENCE 217 AA; 24728 MW; C03009DA53071864 CRC64;
MDPVVLSYMD SLLRQSDVSL LDPPNWLNDH IIGFAFEYFA SSQFHDCSDH VCFISPEVTQ
FIKCTSSPAE IAMFLEPLDL PHKRVVFLAI NDNSNQAAGG THWSLLVYLQ DKNSFFHYDS
HSRSNSIHAK QVAEKLKAFL GSKGDKLVFV EEKAPAQQNS YDCGMYVICN TEALCQNLFR
RQPESPLQLL TPTYITKKRG EWKDLIARLA KKNRSSY
