SEO1_YEAST
ID SEO1_YEAST Reviewed; 593 AA.
AC P39709; D6VPF0;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Probable transporter SEO1;
GN Name=SEO1; OrderedLocusNames=YAL067C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7731988; DOI=10.1073/pnas.92.9.3809;
RA Bussey H., Kaback D.B., Zhong W.-W., Vo D.H., Clark M.W., Fortin N.,
RA Hall J., Ouellette B.F.F., Keng T., Barton A.B., Su Y., Davies C.J.,
RA Storms R.K.;
RT "The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:3809-3813(1995).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Not known; suppressor of sulfoxide ethionine resistance.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Allantoate
CC permease family. {ECO:0000305}.
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DR EMBL; U12980; AAC04968.1; -; Genomic_DNA.
DR EMBL; BK006935; DAA06920.1; -; Genomic_DNA.
DR PIR; S51956; S51956.
DR RefSeq; NP_009333.1; NM_001178208.1.
DR AlphaFoldDB; P39709; -.
DR BioGRID; 31762; 48.
DR DIP; DIP-8291N; -.
DR IntAct; P39709; 2.
DR MINT; P39709; -.
DR STRING; 4932.YAL067C; -.
DR TCDB; 2.A.1.14.37; the major facilitator superfamily (mfs).
DR iPTMnet; P39709; -.
DR PaxDb; P39709; -.
DR PRIDE; P39709; -.
DR EnsemblFungi; YAL067C_mRNA; YAL067C; YAL067C.
DR GeneID; 851230; -.
DR KEGG; sce:YAL067C; -.
DR SGD; S000000062; SEO1.
DR VEuPathDB; FungiDB:YAL067C; -.
DR eggNOG; KOG2533; Eukaryota.
DR HOGENOM; CLU_001265_4_2_1; -.
DR InParanoid; P39709; -.
DR OMA; WNIFCWN; -.
DR BioCyc; YEAST:G3O-28866-MON; -.
DR PRO; PR:P39709; -.
DR Proteomes; UP000002311; Chromosome I.
DR RNAct; P39709; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031224; C:intrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISS:SGD.
DR GO; GO:0015124; F:allantoate transmembrane transporter activity; ISS:SGD.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IMP:SGD.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..593
FT /note="Probable transporter SEO1"
FT /id="PRO_0000121368"
FT TOPO_DOM 1..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..151
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 152..175
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..200
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 222..234
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 256..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..302
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..363
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 385..411
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 412..432
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 433..438
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 460..466
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 488..499
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 500..520
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 521..532
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 533..553
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 554..593
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 593 AA; 68842 MW; 6B7B1A2A7D5EAA44 CRC64;
MYSIVKEIIV DPYKRLKWGF IPVKRQVEDL PDDLNSTEIV TISNSIQSHE TAENFITTTS
EKDQLHFETS SYSEHKDNVN VTRSYEYRDE ADRPWWRFFD EQEYRINEKE RSHNKWYSWF
KQGTSFKEKK LLIKLDVLLA FYSCIAYWVK YLDTVNINNA YVSGMKEDLG FQGNDLVHTQ
VMYTVGNIIF QLPFLIYLNK LPLNYVLPSL DLCWSLLTVG AAYVNSVPHL KAIRFFIGAF
EAPSYLAYQY LFGSFYKHDE MVRRSAFYYL GQYIGILSAG GIQSAVYSSL NGVNGLEGWR
WNFIIDAIVS VVVGLIGFYS LPGDPYNCYS IFLTDDEIRL ARKRLKENQT GKSDFETKVF
DIKLWKTIFS DWKIYILTLW NIFCWNDSNV SSGAYLLWLK SLKRYSIPKL NQLSMITPGL
GMVYLMLTGI IADKLHSRWF AIIFTQVFNI IGNSILAAWD VAEGAKWFAF MLQCFGWAMA
PVLYSWQNDI CRRDAQTRAI TLVTMNIMAQ SSTAWISVLV WKTEEAPRYL KGFTFTACSA
FCLSIWTFVV LYFYKRDERN NAKKNGIVLY NSKHGVEKPT SKDVETLSVS DEK
