ID   SEP15_DANRE             Reviewed;         153 AA.
AC   Q802F3; Q6IQ99;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Selenoprotein F {ECO:0000250|UniProtKB:O60613};
DE   AltName: Full=15 kDa selenoprotein {ECO:0000303|PubMed:12915322};
DE   Flags: Precursor;
GN   Name=selenof {ECO:0000250|UniProtKB:O60613};
GN   Synonyms=cb29, sep15 {ECO:0000312|ZFIN:ZDB-GENE-030327-1};
GN   ORFNames=zgc:86882;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAO65272.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Embryo;
RX   PubMed=12915322; DOI=10.1016/s1567-133x(03)00054-1;
RA   Thisse C., Degrave A., Kryukov G.V., Gladyshev V.N., Obrecht-Pflumio S.,
RA   Krol A., Thisse B., Lescure A.;
RT   "Spatial and temporal expression patterns of selenoprotein genes during
RT   embryogenesis in zebrafish.";
RL   Gene Expr. Patterns 3:525-532(2003).
RN   [2] {ECO:0000312|EMBL:AAH71511.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH71511.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in redox reactions associated with the
CC       formation of disulfide bonds. May contribute to the quality control of
CC       protein folding in the endoplasmic reticulum (By similarity).
CC       {ECO:0000250|UniProtKB:O60613}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen
CC       {ECO:0000250|UniProtKB:O60613}.
CC   -!- TISSUE SPECIFICITY: Higher levels in polster, prechordal plate, axis,
CC       otic vesicle and somites. Lower levels in fin buds.
CC       {ECO:0000269|PubMed:12915322}.
CC   -!- SIMILARITY: Belongs to the selenoprotein M/F family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH71511.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY221263; AAO65272.1; -; mRNA.
DR   EMBL; BC071511; AAH71511.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_840079.1; NM_178294.5.
DR   STRING; 7955.ENSDARP00000114895; -.
DR   PaxDb; Q802F3; -.
DR   Ensembl; ENSDART00000158486; ENSDARP00000137608; ENSDARG00000099664.
DR   GeneID; 352923; -.
DR   KEGG; dre:352923; -.
DR   CTD; 9403; -.
DR   ZFIN; ZDB-GENE-030327-1; selenof.
DR   eggNOG; KOG3384; Eukaryota.
DR   GeneTree; ENSGT00940000154284; -.
DR   InParanoid; Q802F3; -.
DR   OMA; FPQVQFV; -.
DR   OrthoDB; 1405992at2759; -.
DR   PhylomeDB; Q802F3; -.
DR   TreeFam; TF315117; -.
DR   PRO; PR:Q802F3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000099664; Expressed in somite and 39 other tissues.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; ISS:UniProtKB.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   GO; GO:0008430; F:selenium binding; ISS:UniProtKB.
DR   Gene3D; 3.40.30.50; -; 1.
DR   InterPro; IPR038219; Sep15/SelM_sf.
DR   InterPro; IPR039992; Sep15_SelM.
DR   InterPro; IPR014912; Sep15_SelM_dom.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR13077; PTHR13077; 1.
DR   Pfam; PF08806; Sep15_SelM; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Reference proteome; Selenocysteine; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..153
FT                   /note="Selenoprotein F"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000022306"
FT   NON_STD         84
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000312|EMBL:AAO65272.1"
SQ   SEQUENCE   153 AA;  17223 MW;  B710152C26192481 CRC64;
     MAGEVYLLWL LPLLQGLASY GAELSSEACR ELGFSSNLLC SSCELLGQFS LNQLDLPCRQ
     CCQEEAQLEN RKLYPGAILE VCGUKLGRFP QVQAFVRSDK PKLFRGLQIK YVRGSDPVLK
     LLDDNGNIAE ELSILKWNTD SVEEFLSEKL ERI