ID   SEP15_ONCMY             Reviewed;         157 AA.
AC   Q6X4M2;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   23-FEB-2022, entry version 47.
DE   RecName: Full=Selenoprotein F {ECO:0000250|UniProtKB:O60613};
DE   Flags: Precursor;
GN   Name=selenof {ECO:0000250|UniProtKB:O60613};
GN   Synonyms=sep15 {ECO:0000303|PubMed:14662307};
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAP94226.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Retina {ECO:0000269|PubMed:14662307};
RX   PubMed=14662307; DOI=10.1016/s1096-4959(03)00262-8;
RA   Dann S.G., Allison W.T., Levin D.B., Hawryshyn C.W.;
RT   "Identification of a unique transcript down-regulated in the retina of
RT   rainbow trout (Oncorhynchus mykiss) at smoltification.";
RL   Comp. Biochem. Physiol. 136B:849-860(2003).
CC   -!- FUNCTION: May be involved in redox reactions associated with the
CC       formation of disulfide bonds. May contribute to the quality control of
CC       protein folding in the endoplasmic reticulum (By similarity). May be
CC       involved in retinal development. {ECO:0000250,
CC       ECO:0000269|PubMed:14662307}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in the brain, liver and retina. Localized
CC       to the retinal ganglion cell layer, the inner nuclear layer and the
CC       outer nuclear layer at both parr and smolt stages.
CC       {ECO:0000269|PubMed:14662307}.
CC   -!- SIMILARITY: Belongs to the selenoprotein M/F family. {ECO:0000305}.
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DR   EMBL; AY255833; AAP94226.1; -; mRNA.
DR   RefSeq; NP_001117926.1; NM_001124454.1.
DR   GeneID; 110530087; -.
DR   KEGG; omy:110530087; -.
DR   CTD; 9403; -.
DR   OrthoDB; 1405992at2759; -.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; ISS:UniProtKB.
DR   Gene3D; 3.40.30.50; -; 1.
DR   InterPro; IPR038219; Sep15/SelM_sf.
DR   InterPro; IPR039992; Sep15_SelM.
DR   InterPro; IPR014912; Sep15_SelM_dom.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR13077; PTHR13077; 1.
DR   Pfam; PF08806; Sep15_SelM; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Selenocysteine; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..157
FT                   /note="Selenoprotein F"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000022309"
FT   NON_STD         84
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000303|PubMed:14662307"
SQ   SEQUENCE   157 AA;  17590 MW;  19141B26AF8A1C0A CRC64;
     MSGEVYILWL LSLIQTLSAY GADLSSEACR ELGFSSCWGC SSCDLLGEFS LSSIQPVCKQ
     CCQQEVHMES RKLYPGAILE VCGUKLGRFP QVQAFVRSDK PKMFKGLQIK YVRGADPILK
     LLDDNGNIAE EPSILKWNTD SVEEFLSEKL EVYNTDL