ID   SEP15_PIG               Reviewed;         162 AA.
AC   A1Z623;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 2.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Selenoprotein F {ECO:0000250|UniProtKB:O60613};
DE   AltName: Full=15 kDa selenoprotein {ECO:0000303|Ref.1};
DE   Flags: Precursor;
GN   Name=SELENOF {ECO:0000250|UniProtKB:O60613};
GN   Synonyms=SEP15 {ECO:0000312|EMBL:ABM54177.1};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spleen;
RA   Zhou J.C., Zhao H., Sun Q., Wang K.N., Xia X.J., Lei X.G.;
RT   "Cloning and characterization of pig selenoprotein 15kDa.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in redox reactions associated with the
CC       formation of disulfide bonds (By similarity). May contribute to the
CC       quality control of protein folding in the endoplasmic reticulum. May
CC       regulate protein folding by enhancing the catalytic activity of
CC       UGGT1/UGCGL1 and UGGT2/UGCGL2 (By similarity).
CC       {ECO:0000250|UniProtKB:O60613, ECO:0000250|UniProtKB:Q923V8}.
CC   -!- SUBUNIT: Forms a tight complex with UGGT1/UGCGL1. Interacts with
CC       UGGT2/UGCGL2. Interacts with RDH11. {ECO:0000250|UniProtKB:O60613}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250}.
CC       Note=The association with UGGT1/UGCGL1 is essential for its retention
CC       in the endoplasmic reticulum. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the selenoprotein M/F family. {ECO:0000305}.
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DR   EMBL; EF178474; ABM54177.1; -; mRNA.
DR   RefSeq; NP_001078912.1; NM_001085443.1.
DR   STRING; 9823.ENSSSCP00000023410; -.
DR   PaxDb; A1Z623; -.
DR   PeptideAtlas; A1Z623; -.
DR   PRIDE; A1Z623; -.
DR   Ensembl; ENSSSCT00000028257; ENSSSCP00000023410; ENSSSCG00000030125.
DR   Ensembl; ENSSSCT00015069317; ENSSSCP00015027755; ENSSSCG00015052041.
DR   Ensembl; ENSSSCT00025008955; ENSSSCP00025003526; ENSSSCG00025006762.
DR   Ensembl; ENSSSCT00030016349; ENSSSCP00030007319; ENSSSCG00030011926.
DR   Ensembl; ENSSSCT00035103035; ENSSSCP00035044020; ENSSSCG00035075794.
DR   Ensembl; ENSSSCT00040087579; ENSSSCP00040038473; ENSSSCG00040064151.
DR   Ensembl; ENSSSCT00045022408; ENSSSCP00045015436; ENSSSCG00045013163.
DR   Ensembl; ENSSSCT00050064105; ENSSSCP00050027588; ENSSSCG00050047072.
DR   Ensembl; ENSSSCT00055042936; ENSSSCP00055034158; ENSSSCG00055021860.
DR   Ensembl; ENSSSCT00060075079; ENSSSCP00060032428; ENSSSCG00060055116.
DR   Ensembl; ENSSSCT00065073845; ENSSSCP00065032157; ENSSSCG00065053918.
DR   Ensembl; ENSSSCT00070031340; ENSSSCP00070026124; ENSSSCG00070015960.
DR   GeneID; 100038009; -.
DR   KEGG; ssc:100038009; -.
DR   CTD; 9403; -.
DR   VGNC; VGNC:98854; SELENOF.
DR   eggNOG; KOG3384; Eukaryota.
DR   GeneTree; ENSGT00940000154284; -.
DR   InParanoid; A1Z623; -.
DR   OMA; FPQVQFV; -.
DR   OrthoDB; 1405992at2759; -.
DR   Proteomes; UP000008227; Chromosome 4.
DR   Proteomes; UP000314985; Chromosome 4.
DR   Bgee; ENSSSCG00000030125; Expressed in hindlimb bud and 42 other tissues.
DR   GO; GO:0005788; C:endoplasmic reticulum lumen; IBA:GO_Central.
DR   GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR   Gene3D; 3.40.30.50; -; 1.
DR   InterPro; IPR038219; Sep15/SelM_sf.
DR   InterPro; IPR039992; Sep15_SelM.
DR   InterPro; IPR014912; Sep15_SelM_dom.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR13077; PTHR13077; 1.
DR   Pfam; PF08806; Sep15_SelM; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Reference proteome; Selenocysteine; Signal.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..162
FT                   /note="Selenoprotein F"
FT                   /id="PRO_0000318610"
FT   NON_STD         93
FT                   /note="Selenocysteine"
SQ   SEQUENCE   162 AA;  17843 MW;  E502C9CA9E374371 CRC64;
     MAAEPGGWLG PALGLRLLLA TALQMVSAFG AEFSSESCRE LGFSSNLLCG SCDLLGQFDL
     LQLDPDCRGC CQEEAQFETK KLYAGAILEV CGUKLGRFPQ VQAFVRSDKP KLFRGLQIKY
     VRGSDPVLKL LDDNGNIAEE LSILKWNTDS VEEFLSEKLQ RV