ID   SEP8A_DANRE             Reviewed;         420 AA.
AC   Q642H3; Q498W9; Q7SXT0;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Septin-8-A;
GN   Name=sept8a;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. Septin GTPase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01056}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH55257.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAH81662.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAI00045.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC055257; AAH55257.1; ALT_INIT; mRNA.
DR   EMBL; BC081662; AAH81662.1; ALT_INIT; mRNA.
DR   EMBL; BC100044; AAI00045.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001108589.1; NM_001115117.1.
DR   AlphaFoldDB; Q642H3; -.
DR   SMR; Q642H3; -.
DR   STRING; 7955.ENSDARP00000102463; -.
DR   PaxDb; Q642H3; -.
DR   GeneID; 321590; -.
DR   KEGG; dre:321590; -.
DR   CTD; 321590; -.
DR   ZFIN; ZDB-GENE-030131-309; sept8a.
DR   eggNOG; KOG3859; Eukaryota.
DR   InParanoid; Q642H3; -.
DR   OrthoDB; 845354at2759; -.
DR   PhylomeDB; Q642H3; -.
DR   PRO; PR:Q642H3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR   GO; GO:0031105; C:septin complex; IBA:GO_Central.
DR   GO; GO:0005940; C:septin ring; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0061640; P:cytoskeleton-dependent cytokinesis; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   CDD; cd01850; CDC_Septin; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030379; G_SEPTIN_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016491; Septin.
DR   Pfam; PF00735; Septin; 1.
DR   PIRSF; PIRSF006698; Septin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51719; G_SEPTIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..420
FT                   /note="Septin-8-A"
FT                   /id="PRO_0000363229"
FT   DOMAIN          39..305
FT                   /note="Septin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          49..56
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          101..104
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          184..187
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          393..420
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          321..407
FT                   /evidence="ECO:0000255"
FT   BINDING         49..56
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         104
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         185..193
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         239
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         254
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        136
FT                   /note="V -> I (in Ref. 1; AAH55257/AAI00045)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   420 AA;  48999 MW;  C16F6C8FB549B6DD CRC64;
     MAATDVDIFS NEEKRNLSLG GHVGFDSLPD QLVSKSVTQG FCFNILCVGE TGIGKSTLMN
     TLFNTMFENE EASHYQNGVY LRPRTYDLQE SNVHLKLTIV DTVGFGDQIN KEESYKPIVD
     YIDTQFENYL QEELKVKRSL FNYHDTRIHI CLYFISPTGH SLKSLDLVTM KKLDSKVNII
     PIIAKADTIS KSELHKFKIK IMSELVSNGV QIYQFPTDDE AVTEINSSMN AHLPFAVVGS
     VEEVKVGNKT VRARQYPWGV VQVENESHCD FVKLREMLIR VNMEDLREQT HARHYELYRR
     CKLEEMGFKD TDPDSQPFSL QETYEAKRKE FLGDLQKKEE EMRQMFVNKV KETEAELKEK
     ERELHEKFEQ LKRMHQEEKR KVEEKRRELE EEMNAFNRRK VAAETLSLSQ PLKKDKDKKN