BGL01_ARATH
ID BGL01_ARATH Reviewed; 517 AA.
AC Q3ECW8; F4HRB1; F4HRB2;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Beta-glucosidase 1;
DE Short=AtBGLU1;
DE EC=3.2.1.21;
DE Flags: Precursor;
GN Name=BGLU1; OrderedLocusNames=At1g45191; ORFNames=T2P3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15604686; DOI=10.1007/s11103-004-0790-1;
RA Xu Z., Escamilla-Trevino L.L., Zeng L., Lalgondar M., Bevan D.R.,
RA Winkel B.S.J., Mohamed A., Cheng C.-L., Shih M.-C., Poulton J.E., Esen A.;
RT "Functional genomic analysis of Arabidopsis thaliana glycoside hydrolase
RT family 1.";
RL Plant Mol. Biol. 55:343-367(2004).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing beta-D-glucosyl residues
CC with release of beta-D-glucose.; EC=3.2.1.21;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q3ECW8-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AEE32093.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEE32094.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC084820; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE32093.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE32094.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; ANM60926.1; -; Genomic_DNA.
DR RefSeq; NP_001323174.1; NM_001333250.1. [Q3ECW8-1]
DR RefSeq; NP_849771.2; NM_179440.2.
DR RefSeq; NP_973974.2; NM_202245.2.
DR AlphaFoldDB; Q3ECW8; -.
DR SMR; Q3ECW8; -.
DR STRING; 3702.AT1G45191.1; -.
DR CAZy; GH1; Glycoside Hydrolase Family 1.
DR PaxDb; Q3ECW8; -.
DR PRIDE; Q3ECW8; -.
DR ProteomicsDB; 240463; -. [Q3ECW8-1]
DR EnsemblPlants; AT1G45191.6; AT1G45191.6; AT1G45191. [Q3ECW8-1]
DR GeneID; 841088; -.
DR Gramene; AT1G45191.6; AT1G45191.6; AT1G45191. [Q3ECW8-1]
DR KEGG; ath:AT1G45191; -.
DR Araport; AT1G45191; -.
DR TAIR; locus:1005716680; AT1G45191.
DR eggNOG; KOG0626; Eukaryota.
DR HOGENOM; CLU_001859_1_0_1; -.
DR InParanoid; Q3ECW8; -.
DR OrthoDB; 408001at2759; -.
DR BioCyc; ARA:AT1G45191-MON; -.
DR PRO; PR:Q3ECW8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q3ECW8; baseline and differential.
DR GO; GO:0008422; F:beta-glucosidase activity; IBA:GO_Central.
DR GO; GO:0102483; F:scopolin beta-glucosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10353; PTHR10353; 1.
DR Pfam; PF00232; Glyco_hydro_1; 1.
DR PRINTS; PR00131; GLHYDRLASE1.
DR SUPFAM; SSF51445; SSF51445; 1.
DR PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Disulfide bond; Glycoprotein; Glycosidase; Hydrolase;
KW Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..517
FT /note="Beta-glucosidase 1"
FT /id="PRO_0000389563"
FT ACT_SITE 191
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 406
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT BINDING 48
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 145
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 190
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 333
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 451
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 458..459
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT CARBOHYD 216
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 221
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 441
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 473
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 512
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 210..217
FT /evidence="ECO:0000250"
SQ SEQUENCE 517 AA; 58585 MW; 726DA4B0420B2EAC CRC64;
MEDVLTLITM IVLLLLAFHG FGKCSSDLYS RSDFPEGFVF GAGISAYQWE GAVDEDGRKP
SVWDTFLHCR KMDNGDIACD GYHKYKEDVQ LMAETGLHTF RFSISWSRLI SNGRGSINPK
GLQFYKNFIQ ELVKHGIEPH VTLHHYDFPQ YLEDDYGGWT NRKIIKDFTA YADVCFREFG
NHVKFWTTIN EANIFTIGGY NDGNSPPGRC SFPGRNCTLG NSSTETYIVG HNLLLAHASV
SRLYKQKYKD IQGGSVGFSL FAMNFTPSTN SKDDEIATKR ANDFYLGWML EPLIYGDYPD
VMKRTIGSRL PVFSKEESEQ VKGSSDFIGV IHYLTALVTN IDINPSLSGI PDFNSDMGES
INILSMRVRI SRLPNSDEKC LIFFITLSIL EYIKQSYGNP PVYILENGKT MNQDLELQQK
DTPRIEYLDA YIGAVLKAVR NGSDTRGYFV WSFMDLYELL NGYKSSFGLY SVNFSDPHRK
RSPKLSAHWY SGFLKGKPTF LGSQGITQLH SNFSSSR
