ID   SEP8A_XENLA             Reviewed;         427 AA.
AC   Q6AXA6;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Septin-8-A;
GN   Name=sept8-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. Septin GTPase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01056}.
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DR   EMBL; BC079687; AAH79687.1; -; mRNA.
DR   RefSeq; NP_001087375.1; NM_001093906.1.
DR   AlphaFoldDB; Q6AXA6; -.
DR   SMR; Q6AXA6; -.
DR   BioGRID; 104059; 1.
DR   IntAct; Q6AXA6; 1.
DR   DNASU; 447199; -.
DR   GeneID; 447199; -.
DR   KEGG; xla:447199; -.
DR   CTD; 447199; -.
DR   Xenbase; XB-GENE-1032912; septin8.L.
DR   OrthoDB; 845354at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 447199; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   CDD; cd01850; CDC_Septin; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030379; G_SEPTIN_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR030646; SEPT8.
DR   InterPro; IPR016491; Septin.
DR   PANTHER; PTHR18884:SF54; PTHR18884:SF54; 1.
DR   Pfam; PF00735; Septin; 1.
DR   PIRSF; PIRSF006698; Septin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51719; G_SEPTIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..427
FT                   /note="Septin-8-A"
FT                   /id="PRO_0000363231"
FT   DOMAIN          39..305
FT                   /note="Septin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          49..56
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          101..104
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          184..187
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          376..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          320..409
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        376..398
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..417
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         49..56
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         104
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         185..193
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         239
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         254
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   427 AA;  49738 MW;  0039E52F2D503798 CRC64;
     MAATDVQRAS NEEKRSLAMS GHVGFDSLPD QLVSKSVTQG FCFNILCVGE TGIGKSTLMN
     TLFNTTFETE EASHYENGVC LRPRTYDLQE SNVHLKLTIV DTVGFGDQIN KDDSYRSVVD
     YIDTQFENYL QEELKIRRSL FNFHDSRIHV CLYFITPTGH SLKSLDLVTM KKLDSKVNII
     PIIAKADTIS KSELHKFKIK IMSELVSNGV QIYQFPTDDD AVAEINSVMN AHLPFAVVGS
     TEEVKVGNKL VRARQYPWGV VQVENESHCD FVKLREMLIR VNMEDLREQT HTRHYELYRR
     CKLEEMGFKD NDPDTQPFSL QETYEAKRKE FLSELQRKEE EMRQMFVNKV KETEAELKER
     ERELQEKFMQ LKRIHQEESK KVEDKRRDLE EEMNSFNRRK AAMEALQSQS FQATSQQPLK
     KDKDRKN