ID   SEP8B_DANRE             Reviewed;         423 AA.
AC   A4FUM1;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Septin-8-B;
GN   Name=sept8b;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. Septin GTPase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01056}.
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DR   EMBL; BC115182; AAI15183.1; -; mRNA.
DR   RefSeq; NP_001077035.1; NM_001083566.1.
DR   AlphaFoldDB; A4FUM1; -.
DR   SMR; A4FUM1; -.
DR   STRING; 7955.ENSDARP00000026858; -.
DR   PaxDb; A4FUM1; -.
DR   PeptideAtlas; A4FUM1; -.
DR   GeneID; 571702; -.
DR   KEGG; dre:571702; -.
DR   CTD; 571702; -.
DR   ZFIN; ZDB-GENE-070424-3; sept8b.
DR   eggNOG; KOG3859; Eukaryota.
DR   InParanoid; A4FUM1; -.
DR   OrthoDB; 845354at2759; -.
DR   PhylomeDB; A4FUM1; -.
DR   PRO; PR:A4FUM1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR   GO; GO:0015630; C:microtubule cytoskeleton; IBA:GO_Central.
DR   GO; GO:0031105; C:septin complex; IBA:GO_Central.
DR   GO; GO:0005940; C:septin ring; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0061640; P:cytoskeleton-dependent cytokinesis; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   CDD; cd01850; CDC_Septin; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030379; G_SEPTIN_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR030646; SEPT8.
DR   InterPro; IPR016491; Septin.
DR   PANTHER; PTHR18884:SF54; PTHR18884:SF54; 1.
DR   Pfam; PF00735; Septin; 1.
DR   PIRSF; PIRSF006698; Septin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51719; G_SEPTIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..423
FT                   /note="Septin-8-B"
FT                   /id="PRO_0000363230"
FT   DOMAIN          39..305
FT                   /note="Septin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          49..56
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          101..104
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          184..187
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   COILED          338..404
FT                   /evidence="ECO:0000255"
FT   BINDING         49..56
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         104
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         185..193
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         239
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         254
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   423 AA;  49099 MW;  5C030D5FF71B397E CRC64;
     MAATEVNTYP TEEMRSLSLS GHVGFDSLPD QLVSKSVSQG FSFNILCVGE TGIGKSTLMN
     TLFNTTFENE EASHFHNGVH LRPRTYSLQE SNVDLQLTIV DTVGFGDQVN KEESYKPIVD
     YIDAQFENFL EEELKIKRSL YNYHDSRIHI CLYFIAPTGH SLKSLDLVTM KKLDSKVNII
     PIIAKADTVS KSELQKFKIK IMSELVSNGV QIYQFPTDDE AVAEINSSMN AHLPFAVIGS
     SEEVKIGNKM VRARQYPWGV VQVENESHCD FVKLREMLIR VNMLDLREQT HARHYELYRR
     CKLEEMGFKD TDADSEPFSL QETYVAKRRE FIVELQMKEE QMRQMFVNKV KETEAELKEK
     ERELHERFEM LKRTHQEEKR SLEEMRRDFE EEMNTFNRRK VAAETLQSLQ GSTGLKKDKE
     KKT