ID   SEP8B_XENLA             Reviewed;         427 AA.
AC   Q6IRQ5;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Septin-8-B;
GN   Name=sept8-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. Septin GTPase family. {ECO:0000255|PROSITE-
CC       ProRule:PRU01056}.
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DR   EMBL; BC070648; AAH70648.1; -; mRNA.
DR   RefSeq; NP_001084958.1; NM_001091489.1.
DR   AlphaFoldDB; Q6IRQ5; -.
DR   SMR; Q6IRQ5; -.
DR   GeneID; 432016; -.
DR   KEGG; xla:432016; -.
DR   CTD; 432016; -.
DR   Xenbase; XB-GENE-6256297; septin8.S.
DR   OrthoDB; 845354at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 432016; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   CDD; cd01850; CDC_Septin; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR030379; G_SEPTIN_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR030646; SEPT8.
DR   InterPro; IPR016491; Septin.
DR   PANTHER; PTHR18884:SF54; PTHR18884:SF54; 1.
DR   Pfam; PF00735; Septin; 1.
DR   PIRSF; PIRSF006698; Septin; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51719; G_SEPTIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; GTP-binding; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..427
FT                   /note="Septin-8-B"
FT                   /id="PRO_0000363232"
FT   DOMAIN          39..305
FT                   /note="Septin-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          49..56
FT                   /note="G1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          101..104
FT                   /note="G3 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          184..187
FT                   /note="G4 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01056"
FT   REGION          406..427
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          320..407
FT                   /evidence="ECO:0000255"
FT   BINDING         49..56
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         104
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         185..193
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         239
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         254
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   427 AA;  49761 MW;  B0CFFF8F4799FA5F CRC64;
     MAATDVERAS NEEKRSLALS GHVGFDSLPD QLVGKSVTQG FCFNILCVGE TGIGKSTLMN
     TLFNTTFETE EASHYENGVR LRPRTYELQE SNVHLKLTIV DTVGFGDQIN KDDSYRSVVD
     YIDTQFETYL QEELKIRRSL FNYHDSRIHV CLYFITPTGH SLKSLDLVAM KKLDSKVNII
     PIIAKADTIS KSELHKFKIK IMSELVSNGV QIYQFPTDDD AVAEINSVMN AHLPFAVVGS
     TEEVKVGNKL VRARQYPWGV VQVENESHCD FVKLREMLIR VNMEDLREQT HTRHYELYRR
     CKLEEMGFKD NDPDTQPFSL QETYEAKRKE FLSELQKKEE EMRQMFVNKV KETESELKER
     ERELQEKFMQ LKRIHQEESK KVEDKRRDLE EEMNAFNRRK VAMETLQSQS FQATSQQPLK
     KDKDRKN