ID   SEPF_STRPN              Reviewed;         179 AA.
AC   P0CB77; Q7D493; Q9ZHB7;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-NOV-2009, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Cell division protein SepF;
GN   Name=sepF; OrderedLocusNames=SP_1664;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
RN   [2]
RP   FUNCTION IN CELL DIVISION.
RC   STRAIN=Rx1;
RX   PubMed=14526035; DOI=10.1128/jb.185.20.6209-6214.2003;
RA   Fadda D., Pischedda C., Caldara F., Whalen M.B., Anderluzzi D.,
RA   Domenici E., Massidda O.;
RT   "Characterization of divIVA and other genes located in the chromosomal
RT   region downstream of the dcw cluster in Streptococcus pneumoniae.";
RL   J. Bacteriol. 185:6209-6214(2003).
CC   -!- FUNCTION: Cell division protein that is part of the divisome complex
CC       and is recruited early to the Z-ring. Probably stimulates Z-ring
CC       formation, perhaps through the cross-linking of FtsZ protofilaments.
CC       Its function overlaps with FtsA (By similarity). {ECO:0000250,
CC       ECO:0000269|PubMed:14526035}.
CC   -!- SUBUNIT: Homodimer. Interacts with FtsZ (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localizes to the
CC       division site, in a FtsZ-dependent manner. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SepF family. {ECO:0000305}.
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DR   EMBL; AE005672; AAK75743.1; -; Genomic_DNA.
DR   PIR; F95193; F95193.
DR   RefSeq; WP_000053388.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P0CB77; -.
DR   SMR; P0CB77; -.
DR   STRING; 170187.SP_1664; -.
DR   EnsemblBacteria; AAK75743; AAK75743; SP_1664.
DR   KEGG; spn:SP_1664; -.
DR   eggNOG; COG1799; Bacteria.
DR   OMA; ASERHYQ; -.
DR   PhylomeDB; P0CB77; -.
DR   BioCyc; SPNE170187:G1FZB-1685-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.110.150; -; 1.
DR   HAMAP; MF_01197; SepF; 1.
DR   InterPro; IPR023052; Cell_div_SepF.
DR   InterPro; IPR007561; Cell_div_SepF/SepF-rel.
DR   InterPro; IPR038594; SepF-like_sf.
DR   PANTHER; PTHR35798; PTHR35798; 1.
DR   Pfam; PF04472; SepF; 1.
PE   1: Evidence at protein level;
KW   Cell cycle; Cell division; Cytoplasm; Septation.
FT   CHAIN           1..179
FT                   /note="Cell division protein SepF"
FT                   /id="PRO_0000334096"
FT   REGION          22..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        31..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   179 AA;  20627 MW;  6A6B297EE65C342C CRC64;
     MSLKDRFDRF IDYFTEDEDS SLPYEKRDEP VFTSVNSSQE PALPMNQPSQ SAGTKENNIT
     RLHARQQELA NQSQRATDKV IIDVRYPRKY EDATEIVDLL AGNESILIDF QYMTEVQARR
     CLDYLDGACH VLAGNLKKVA STMYLLTPVN VIVNVEDIRL PDEDQQGEFG FDMKRNRVR