SERA_ENTHI
ID SERA_ENTHI Reviewed; 233 AA.
AC P21138;
DT 01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1991, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Serine-rich 25 kDa antigen protein;
DE Short=SREHP;
DE AltName: Full=SHEHP;
OS Entamoeba histolytica.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=5759;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=ATCC 30459 / HM-1:IMSS;
RX PubMed=1695007; DOI=10.1073/pnas.87.13.4976;
RA Stanley S.L. Jr., Becker A., Kunz-Jenkins C., Foster L., Li E.;
RT "Cloning and expression of a membrane antigen of Entamoeba histolytica
RT possessing multiple tandem repeats.";
RL Proc. Natl. Acad. Sci. U.S.A. 87:4976-4980(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1741023; DOI=10.1016/0166-6851(92)90234-b;
RA Li E., Stanley S.L. Jr.;
RT "Isolation and characterization of genomic clones encoding a serine-rich
RT Entamoeba histolytica protein.";
RL Mol. Biochem. Parasitol. 50:355-358(1992).
RN [3]
RP PHOSPHORYLATION, AND GLYCOSYLATION.
RX PubMed=7876162; DOI=10.1074/jbc.270.8.4121;
RA Stanley S.L. Jr., Tian K., Koester J.P., Li E.;
RT "The serine-rich Entamoeba histolytica protein is a phosphorylated membrane
RT protein containing O-linked terminal N-acetylglucosamine residues.";
RL J. Biol. Chem. 270:4121-4126(1995).
CC -!- SUBCELLULAR LOCATION: Membrane.
CC -!- PTM: Phosphorylated on serine residue(s). {ECO:0000269|PubMed:7876162}.
CC -!- PTM: O-glycosylated; glycans consist of single N-acetylglucosamine
CC residues. {ECO:0000269|PubMed:7876162}.
CC -!- PTM: O-acylated; acyl group is probably palmitate, not myristate.
CC {ECO:0000269|PubMed:7876162}.
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DR EMBL; M34438; AAA74500.1; -; mRNA.
DR EMBL; M80910; AAA29117.1; -; Genomic_DNA.
DR AlphaFoldDB; P21138; -.
DR SMR; P21138; -.
DR GlyConnect; 555; 1 O-Linked glycan.
DR VEuPathDB; AmoebaDB:EHI5A_211690; -.
DR VEuPathDB; AmoebaDB:EHI_116360; -.
DR eggNOG; ENOG502RSM7; Eukaryota.
DR OMA; CAGMSRE; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Glycoprotein; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Repeat;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..233
FT /note="Serine-rich 25 kDa antigen protein"
FT /id="PRO_0000097690"
FT TRANSMEM 217..233
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 82..93
FT /note="1-1"
FT REPEAT 102..113
FT /note="1-2"
FT REPEAT 114..125
FT /note="1-3"
FT REPEAT 126..137
FT /note="1-4"
FT REPEAT 138..149
FT /note="1-5"
FT REPEAT 150..161
FT /note="1-6"
FT REPEAT 162..169
FT /note="2-1"
FT REPEAT 170..177
FT /note="2-2"
FT REPEAT 178..185
FT /note="2-3"
FT REPEAT 186..193
FT /note="2-4"
FT REGION 35..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..161
FT /note="6 X 12 AA tandem repeats of S-S-S-D-K-P-D-N-K-P-E-A"
FT REGION 162..193
FT /note="4 X 8 AA tandem repeats of S-S-T-N-K-P-E-A"
FT COMPBIAS 38..61
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..161
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 233 AA; 24719 MW; 5B2FE4081E8E6971 CRC64;
MFAFLLFIAF TSATNIILDL DQEVKDTNIY GVFLKNEASP EKLEEAEEKE KSSSAKPESS
SNEDNEDDED EKASSSDNSE SSSSDKPDNK PEASSSDKPE ASSSDKPDNK PEASSSDKPD
NKPEASSSDK PDNKPEASSS DKPDNKPEAS SSDKPDNKPE ASSTNKPEAS STNKPEASST
NKPEASSTNK PEASSTSNSN DKSGSSSDND NNNLDAASSP FIVFCAIIIA IIF
