ID   SERC2_BOVIN             Reviewed;         452 AA.
AC   Q58CW5;
DT   30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Serine incorporator 2;
DE   AltName: Full=Tumor differentially expressed protein 2-like;
GN   Name=SERINC2; Synonyms=TDE2L;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TDE1 family. {ECO:0000305}.
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DR   EMBL; BT021832; AAX46679.1; -; mRNA.
DR   AlphaFoldDB; Q58CW5; -.
DR   SMR; Q58CW5; -.
DR   STRING; 9913.ENSBTAP00000015387; -.
DR   PaxDb; Q58CW5; -.
DR   Ensembl; ENSBTAT00000076368; ENSBTAP00000057114; ENSBTAG00000035081.
DR   VEuPathDB; HostDB:ENSBTAG00000035081; -.
DR   VGNC; VGNC:106920; SERINC2.
DR   eggNOG; KOG2592; Eukaryota.
DR   GeneTree; ENSGT01030000234623; -.
DR   HOGENOM; CLU_029574_5_1_1; -.
DR   InParanoid; Q58CW5; -.
DR   OMA; WYRPDES; -.
DR   Proteomes; UP000009136; Chromosome 2.
DR   Bgee; ENSBTAG00000035081; Expressed in placenta and 104 other tissues.
DR   ExpressionAtlas; Q58CW5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006658; P:phosphatidylserine metabolic process; IEA:InterPro.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR   InterPro; IPR029554; SERINC2.
DR   InterPro; IPR005016; TDE1/TMS.
DR   PANTHER; PTHR10383; PTHR10383; 1.
DR   PANTHER; PTHR10383:SF22; PTHR10383:SF22; 1.
DR   Pfam; PF03348; Serinc; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..452
FT                   /note="Serine incorporator 2"
FT                   /id="PRO_0000236234"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        205..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..256
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        319..339
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        387..407
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        426..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   452 AA;  50425 MW;  AA0937539249155C CRC64;
     MGACLGACSL LSCASCLCGS APCILCSCCP CSHNSTLSRL FFTVFLFLGV LVCVIMLSPG
     VESQLYKLPW VCNEGTGSHV VLQGHIDCGS LLGHRAVYRM CFAMAAFFFL FSLLMVCVRS
     SRDPRAAIQN GFWFFKFLIF VGITVGAFYI PDGSFSNIWF YFGVVGSFIF LLIQLLLLID
     FAHSWNQRWL CKAEECDSRA WYAGLFFFTL LFYALSITAV ALLFVYYTQP GACYEGKVFI
     GLNLTLCVCV SIVAILPKIQ DAQPNSGLLQ ASVITLYTMF VTWLALSNVP DQKCNPHLLT
     HFGNGTVLAG PEGYETHWWD APSIVGLVVF ILCTVFISLR SSDHRQVNSL MQTEECPPVL
     DATQQQVVSE GRAFDNEQDG VTYSYSFFHL CLVLASVHIM MTLTNWYRPG ETRKMISTWT
     AVWVKICASW TGLLLYLWTL VAPLLLPNRD FS