SERC2_HUMAN
ID SERC2_HUMAN Reviewed; 455 AA.
AC Q96SA4; A0AVB4; B4DJK5; B7Z567; B7ZAP2; E7EUZ9; Q86Y23;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 3.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Serine incorporator 2;
DE AltName: Full=Tumor differentially expressed protein 2-like;
GN Name=SERINC2; Synonyms=TDE2L; ORFNames=FKSG84, UNQ263/PRO300;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Wang Y.-G., Gong L.;
RT "Cloning and characterization of FKSG84, a novel gene located on human
RT chromosome 1.";
RL Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Li N., Zhang W., Wan T., Cao X.;
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96SA4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96SA4-2; Sequence=VSP_042464;
CC Name=3;
CC IsoId=Q96SA4-3; Sequence=VSP_042463;
CC Name=4;
CC IsoId=Q96SA4-4; Sequence=VSP_046840;
CC -!- SIMILARITY: Belongs to the TDE1 family. {ECO:0000305}.
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DR EMBL; AF352325; AAK83284.1; -; mRNA.
DR EMBL; AY094595; AAM22522.1; -; mRNA.
DR EMBL; AY358560; AAQ88924.1; -; mRNA.
DR EMBL; AK298512; BAH12803.1; -; mRNA.
DR EMBL; AK316357; BAH14728.1; -; mRNA.
DR EMBL; AK296118; BAG58867.1; -; mRNA.
DR EMBL; AC114494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC084580; AAH84580.1; -; mRNA.
DR EMBL; BC126283; AAI26284.1; -; mRNA.
DR EMBL; BC126285; AAI26286.1; -; mRNA.
DR CCDS; CCDS30662.1; -. [Q96SA4-1]
DR CCDS; CCDS55583.1; -. [Q96SA4-4]
DR CCDS; CCDS55584.1; -. [Q96SA4-3]
DR CCDS; CCDS55585.1; -. [Q96SA4-2]
DR RefSeq; NP_001185966.1; NM_001199037.1. [Q96SA4-3]
DR RefSeq; NP_001185967.1; NM_001199038.1. [Q96SA4-4]
DR RefSeq; NP_001185968.1; NM_001199039.1.
DR RefSeq; NP_061035.2; NM_018565.3. [Q96SA4-2]
DR RefSeq; NP_849196.2; NM_178865.4. [Q96SA4-1]
DR AlphaFoldDB; Q96SA4; -.
DR SMR; Q96SA4; -.
DR BioGRID; 131485; 57.
DR IntAct; Q96SA4; 5.
DR STRING; 9606.ENSP00000362814; -.
DR iPTMnet; Q96SA4; -.
DR PhosphoSitePlus; Q96SA4; -.
DR BioMuta; SERINC2; -.
DR DMDM; 380865453; -.
DR MassIVE; Q96SA4; -.
DR PaxDb; Q96SA4; -.
DR PeptideAtlas; Q96SA4; -.
DR PRIDE; Q96SA4; -.
DR ProteomicsDB; 18537; -.
DR ProteomicsDB; 78094; -. [Q96SA4-1]
DR ProteomicsDB; 78095; -. [Q96SA4-2]
DR ProteomicsDB; 78096; -. [Q96SA4-3]
DR Antibodypedia; 31115; 173 antibodies from 27 providers.
DR DNASU; 347735; -.
DR Ensembl; ENST00000373709.8; ENSP00000362813.3; ENSG00000168528.12. [Q96SA4-1]
DR Ensembl; ENST00000373710.5; ENSP00000362814.1; ENSG00000168528.12. [Q96SA4-4]
DR Ensembl; ENST00000536384.2; ENSP00000439048.1; ENSG00000168528.12. [Q96SA4-2]
DR Ensembl; ENST00000536859.5; ENSP00000444307.1; ENSG00000168528.12. [Q96SA4-3]
DR GeneID; 347735; -.
DR KEGG; hsa:347735; -.
DR MANE-Select; ENST00000373709.8; ENSP00000362813.3; NM_178865.5; NP_849196.2.
DR UCSC; uc001bst.4; human. [Q96SA4-1]
DR CTD; 347735; -.
DR DisGeNET; 347735; -.
DR GeneCards; SERINC2; -.
DR HGNC; HGNC:23231; SERINC2.
DR HPA; ENSG00000168528; Tissue enhanced (liver).
DR MIM; 614549; gene.
DR neXtProt; NX_Q96SA4; -.
DR OpenTargets; ENSG00000168528; -.
DR PharmGKB; PA134933002; -.
DR VEuPathDB; HostDB:ENSG00000168528; -.
DR eggNOG; KOG2592; Eukaryota.
DR GeneTree; ENSGT01030000234623; -.
DR HOGENOM; CLU_029574_5_0_1; -.
DR InParanoid; Q96SA4; -.
DR OMA; WYRPDES; -.
DR TreeFam; TF312881; -.
DR PathwayCommons; Q96SA4; -.
DR Reactome; R-HSA-977347; Serine biosynthesis.
DR SignaLink; Q96SA4; -.
DR BioGRID-ORCS; 347735; 12 hits in 1071 CRISPR screens.
DR ChiTaRS; SERINC2; human.
DR GenomeRNAi; 347735; -.
DR Pharos; Q96SA4; Tbio.
DR PRO; PR:Q96SA4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q96SA4; protein.
DR Bgee; ENSG00000168528; Expressed in mucosa of transverse colon and 128 other tissues.
DR Genevisible; Q96SA4; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0006658; P:phosphatidylserine metabolic process; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR InterPro; IPR029554; SERINC2.
DR InterPro; IPR005016; TDE1/TMS.
DR PANTHER; PTHR10383; PTHR10383; 1.
DR PANTHER; PTHR10383:SF22; PTHR10383:SF22; 1.
DR Pfam; PF03348; Serinc; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..455
FT /note="Serine incorporator 2"
FT /id="PRO_0000218968"
FT TRANSMEM 5..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 96..118
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 131..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 202..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..256
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..339
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 385..407
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 422..444
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..13
FT /note="MGACLGACSLLSC -> MRSMRLREEESPGPSHT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042463"
FT VAR_SEQ 1..13
FT /note="MGACLGACSLLSC -> MDGRMMRSMRLREEESPGPSHT (in isoform
FT 4)"
FT /evidence="ECO:0000305"
FT /id="VSP_046840"
FT VAR_SEQ 4..13
FT /note="CLGACSLLSC -> EGAPDFLSCPRVRR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042464"
FT VARIANT 303
FT /note="G -> S (in dbSNP:rs34728687)"
FT /id="VAR_061838"
FT CONFLICT 4
FT /note="C -> L (in Ref. 1; AAK83284)"
FT /evidence="ECO:0000305"
FT CONFLICT 81
FT /note="V -> A (in Ref. 4; BAH14728)"
FT /evidence="ECO:0000305"
FT CONFLICT 98
FT /note="Y -> H (in Ref. 4; BAH14728)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="F -> FF (in Ref. 3; AAQ88924)"
FT /evidence="ECO:0000305"
FT CONFLICT 368
FT /note="Q -> QQ (in Ref. 1; AAK83284, 2; AAM22522, 3;
FT AAQ88924, 4; BAH12803/BAH14728 and 6; AAH84580/AAI26284/
FT AAI26286)"
FT /evidence="ECO:0000305"
FT CONFLICT 382
FT /note="D -> G (in Ref. 4; BAH14728)"
FT /evidence="ECO:0000305"
FT CONFLICT 451
FT /note="N -> K (in Ref. 1; AAK83284)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 455 AA; 50742 MW; D18D21B535C7A73C CRC64;
MGACLGACSL LSCASCLCGS APCILCSCCP ASRNSTVSRL IFTFFLFLGV LVSIIMLSPG
VESQLYKLPW VCEEGAGIPT VLQGHIDCGS LLGYRAVYRM CFATAAFFFF FTLLMLCVSS
SRDPRAAIQN GFWFFKFLIL VGLTVGAFYI PDGSFTNIWF YFGVVGSFLF ILIQLVLLID
FAHSWNQRWL GKAEECDSRA WYAGLFFFTL LFYLLSIAAV ALMFMYYTEP SGCHEGKVFI
SLNLTFCVCV SIAAVLPKVQ DAQPNSGLLQ ASVITLYTMF VTWSALSSIP EQKCNPHLPT
QLGNETVVAG PEGYETQWWD APSIVGLIIF LLCTLFISLR SSDHRQVNSL MQTEECPPML
DATQQQQQVA ACEGRAFDNE QDGVTYSYSF FHFCLVLASL HVMMTLTNWY KPGETRKMIS
TWTAVWVKIC ASWAGLLLYL WTLVAPLLLR NRDFS
