ID   SERC2_MOUSE             Reviewed;         450 AA.
AC   Q8K0E7;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Serine incorporator 2;
DE   AltName: Full=Tumor differentially expressed protein 2-like;
GN   Name=Serinc2; Synonyms=Tde2l;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TDE1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC031720; AAH31720.1; -; mRNA.
DR   CCDS; CCDS51310.1; -.
DR   RefSeq; NP_766290.2; NM_172702.3.
DR   AlphaFoldDB; Q8K0E7; -.
DR   SMR; Q8K0E7; -.
DR   STRING; 10090.ENSMUSP00000101618; -.
DR   PhosphoSitePlus; Q8K0E7; -.
DR   PaxDb; Q8K0E7; -.
DR   PRIDE; Q8K0E7; -.
DR   ProteomicsDB; 256965; -.
DR   Antibodypedia; 31115; 173 antibodies from 27 providers.
DR   DNASU; 230779; -.
DR   Ensembl; ENSMUST00000105996; ENSMUSP00000101618; ENSMUSG00000023232.
DR   GeneID; 230779; -.
DR   KEGG; mmu:230779; -.
DR   UCSC; uc008uzc.1; mouse.
DR   CTD; 347735; -.
DR   MGI; MGI:1919132; Serinc2.
DR   VEuPathDB; HostDB:ENSMUSG00000023232; -.
DR   eggNOG; KOG2592; Eukaryota.
DR   GeneTree; ENSGT01030000234623; -.
DR   HOGENOM; CLU_029574_5_0_1; -.
DR   InParanoid; Q8K0E7; -.
DR   OMA; WYRPDES; -.
DR   OrthoDB; 1276632at2759; -.
DR   TreeFam; TF312881; -.
DR   Reactome; R-MMU-977347; Serine biosynthesis.
DR   BioGRID-ORCS; 230779; 2 hits in 75 CRISPR screens.
DR   ChiTaRS; Serinc2; mouse.
DR   PRO; PR:Q8K0E7; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q8K0E7; protein.
DR   Bgee; ENSMUSG00000023232; Expressed in manus and 151 other tissues.
DR   ExpressionAtlas; Q8K0E7; baseline and differential.
DR   Genevisible; Q8K0E7; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006658; P:phosphatidylserine metabolic process; ISO:MGI.
DR   GO; GO:1904219; P:positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity; ISO:MGI.
DR   GO; GO:1904222; P:positive regulation of serine C-palmitoyltransferase activity; ISO:MGI.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR   InterPro; IPR029554; SERINC2.
DR   InterPro; IPR005016; TDE1/TMS.
DR   PANTHER; PTHR10383; PTHR10383; 1.
DR   PANTHER; PTHR10383:SF22; PTHR10383:SF22; 1.
DR   Pfam; PF03348; Serinc; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..450
FT                   /note="Serine incorporator 2"
FT                   /id="PRO_0000218969"
FT   TRANSMEM        5..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        264..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        380..402
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   450 AA;  50478 MW;  BD9111690A875B45 CRC64;
     MGACLGACSL LSCASCLCGS APCILCGCCP STRNSTVSRL LFTSFLFLGV LVSIIMLSPG
     VESQLYKLPW VCEDRTQQPL VLQGPLDCGS LLGFRAVYRM CFATAAFFFF FMLLMICVRS
     SRDPRAAIQN GFWFFKFLIL VGITVGAFYI PDGSFPKIWF YFGVVGSFLF ILIQLILFVD
     FAHSWNQRWL CKAEECDSPA WYAGLFFFTF LFYLLSIAAV ALMFVYYTES GACHEGKVFI
     SLNLTFCVCV SIIAVLPKVQ DAQPNSGLLQ ASVITLYTMF VTWSALSNVP DQKCNPHLPT
     KNGTGQVDLE DYSTVWWDAP SIVGLVIFIL CTFFISLRSS DHRQVNSLMQ TEECPAEMVQ
     QQQVAVSDGR AYDNEQDGVT YSYSFFHFCL VLASLHVMMT LTNWYSPGET RKMISTWTSV
     WVKICASWAG LFLYLWTLVA PLLLPNRDFS