SERC3_HUMAN
ID SERC3_HUMAN Reviewed; 473 AA.
AC Q13530; B4DUE9; O43717; Q9BR33;
DT 25-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2002, sequence version 2.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Serine incorporator 3;
DE AltName: Full=Tumor differentially expressed protein 1 {ECO:0000303|PubMed:10559794};
GN Name=SERINC3; Synonyms=DIFF33, TDE1 {ECO:0000303|PubMed:10559794};
GN ORFNames=SBBI99 {ECO:0000303|Ref.3};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANT
RP ALA-437.
RC TISSUE=Placenta;
RX PubMed=10559794;
RX DOI=10.1002/(sici)1098-2744(199911)26:3<189::aid-mc8>3.0.co;2-t;
RA Bossolasco M., Lebel M., Lemieux N., Mes-Masson A.-M.;
RT "The human TDE gene homologue: localization to 20q13.1-13.3 and variable
RT expression in human tumor cell lines and tissue.";
RL Mol. Carcinog. 26:189-200(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RA Dakuor J., Li H., Morrish D.W.;
RL Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Zhang W., Wan T., Cao X.;
RT "Hypothetical human protein SBBI99.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=26416733; DOI=10.1038/nature15400;
RA Usami Y., Wu Y., Goettlinger H.G.;
RT "SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by
RT Nef.";
RL Nature 526:218-223(2015).
RN [8]
RP FUNCTION, SUBCELLULAR LOCATION, AND SUBCELLULAR LOCATION (MICROBIAL
RP INFECTION).
RX PubMed=26416734; DOI=10.1038/nature15399;
RA Rosa A., Chande A., Ziglio S., De Sanctis V., Bertorelli R., Goh S.L.,
RA McCauley S.M., Nowosielska A., Antonarakis S.E., Luban J., Santoni F.A.,
RA Pizzato M.;
RT "HIV-1 Nef promotes infection by excluding SERINC5 from virion
RT incorporation.";
RL Nature 526:212-217(2015).
CC -!- FUNCTION: Restriction factor required to restrict infectivity of
CC lentiviruses, such as HIV-1: acts by inhibiting an early step of viral
CC infection. Impairs the penetration of the viral particle into the
CC cytoplasm (PubMed:26416733, PubMed:26416734).
CC {ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}.
CC -!- INTERACTION:
CC Q13530; P28799: GRN; NbExp=3; IntAct=EBI-1045571, EBI-747754;
CC Q13530; O43933: PEX1; NbExp=3; IntAct=EBI-1045571, EBI-988601;
CC Q13530; O76024: WFS1; NbExp=3; IntAct=EBI-1045571, EBI-720609;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86VE9};
CC Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q9QZI9}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q9QZI9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000305|PubMed:26416734}. Note=(Microbial infection) Upon HIV-1
CC infection, it is redirected to perinuclear region following interaction
CC with HIV-1 Nef, excluding it from virions particles, thereby preventing
CC subsequent antiviral defense activity (Probable).
CC {ECO:0000305|PubMed:26416734}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q13530-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q13530-2; Sequence=VSP_056833;
CC -!- TISSUE SPECIFICITY: Ubiquitous. Expression levels were increased
CC fourfold to tenfold in lung tumor tissues compared with normal
CC pulmonary tissues. {ECO:0000269|PubMed:10559794}.
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9QZI9}.
CC -!- SIMILARITY: Belongs to the TDE1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB48858.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAD34641.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF112227; AAD22448.1; -; mRNA.
DR EMBL; U49188; AAB48858.1; ALT_FRAME; mRNA.
DR EMBL; AF153979; AAD34641.1; ALT_FRAME; mRNA.
DR EMBL; AK300618; BAG62311.1; -; mRNA.
DR EMBL; Z97053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006088; AAH06088.1; -; mRNA.
DR CCDS; CCDS13333.1; -. [Q13530-1]
DR RefSeq; NP_006802.1; NM_006811.3. [Q13530-1]
DR RefSeq; NP_945179.1; NM_198941.2. [Q13530-1]
DR RefSeq; XP_016883090.1; XM_017027601.1.
DR AlphaFoldDB; Q13530; -.
DR SMR; Q13530; -.
DR BioGRID; 116155; 19.
DR IntAct; Q13530; 9.
DR MINT; Q13530; -.
DR STRING; 9606.ENSP00000340243; -.
DR TCDB; 9.A.29.3.4; the lantibiotic immunity protein/serine connector (lip/sip) family.
DR GlyGen; Q13530; 2 sites, 1 O-linked glycan (1 site).
DR iPTMnet; Q13530; -.
DR PhosphoSitePlus; Q13530; -.
DR SwissPalm; Q13530; -.
DR BioMuta; SERINC3; -.
DR DMDM; 25453293; -.
DR EPD; Q13530; -.
DR jPOST; Q13530; -.
DR MassIVE; Q13530; -.
DR MaxQB; Q13530; -.
DR PaxDb; Q13530; -.
DR PeptideAtlas; Q13530; -.
DR PRIDE; Q13530; -.
DR ProteomicsDB; 5183; -.
DR ProteomicsDB; 59520; -. [Q13530-1]
DR Antibodypedia; 43693; 191 antibodies from 27 providers.
DR DNASU; 10955; -.
DR Ensembl; ENST00000255175.5; ENSP00000255175.1; ENSG00000132824.14. [Q13530-1]
DR Ensembl; ENST00000342374.5; ENSP00000340243.4; ENSG00000132824.14. [Q13530-1]
DR GeneID; 10955; -.
DR KEGG; hsa:10955; -.
DR MANE-Select; ENST00000342374.5; ENSP00000340243.4; NM_006811.4; NP_006802.1.
DR UCSC; uc002xme.4; human. [Q13530-1]
DR CTD; 10955; -.
DR DisGeNET; 10955; -.
DR GeneCards; SERINC3; -.
DR HGNC; HGNC:11699; SERINC3.
DR HPA; ENSG00000132824; Low tissue specificity.
DR MIM; 607165; gene.
DR neXtProt; NX_Q13530; -.
DR OpenTargets; ENSG00000132824; -.
DR PharmGKB; PA36418; -.
DR VEuPathDB; HostDB:ENSG00000132824; -.
DR eggNOG; KOG2592; Eukaryota.
DR GeneTree; ENSGT01030000234623; -.
DR HOGENOM; CLU_029574_5_0_1; -.
DR InParanoid; Q13530; -.
DR OMA; GNPRVWY; -.
DR OrthoDB; 1276632at2759; -.
DR PhylomeDB; Q13530; -.
DR TreeFam; TF312881; -.
DR PathwayCommons; Q13530; -.
DR Reactome; R-HSA-977347; Serine biosynthesis.
DR SignaLink; Q13530; -.
DR BioGRID-ORCS; 10955; 15 hits in 1079 CRISPR screens.
DR ChiTaRS; SERINC3; human.
DR GeneWiki; SERINC3; -.
DR GenomeRNAi; 10955; -.
DR Pharos; Q13530; Tbio.
DR PRO; PR:Q13530; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q13530; protein.
DR Bgee; ENSG00000132824; Expressed in endothelial cell and 214 other tissues.
DR ExpressionAtlas; Q13530; baseline and differential.
DR Genevisible; Q13530; HS.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; TAS:ProtInc.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0015194; F:L-serine transmembrane transporter activity; TAS:Reactome.
DR GO; GO:0051607; P:defense response to virus; IDA:UniProtKB.
DR GO; GO:0009597; P:detection of virus; IDA:UniProtKB.
DR GO; GO:0045087; P:innate immune response; IDA:UniProtKB.
DR GO; GO:0006564; P:L-serine biosynthetic process; TAS:Reactome.
DR GO; GO:0006658; P:phosphatidylserine metabolic process; IEA:InterPro.
DR GO; GO:1902237; P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR InterPro; IPR029557; Serinc1/3.
DR InterPro; IPR005016; TDE1/TMS.
DR PANTHER; PTHR10383; PTHR10383; 1.
DR PANTHER; PTHR10383:SF51; PTHR10383:SF51; 1.
DR Pfam; PF03348; Serinc; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Antiviral defense; Cell membrane; Cytoplasm;
KW Glycoprotein; Golgi apparatus; Host-virus interaction; Immunity;
KW Innate immunity; Membrane; Phosphoprotein; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..473
FT /note="Serine incorporator 3"
FT /id="PRO_0000218970"
FT TOPO_DOM 1..96
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 154..159
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..203
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..239
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..329
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 351..406
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 407..427
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 428..446
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 468..473
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT MOD_RES 371
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NRX5"
FT CARBOHYD 34
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..55
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056833"
FT VARIANT 437
FT /note="T -> A"
FT /evidence="ECO:0000269|PubMed:10559794"
FT /id="VAR_014315"
SQ SEQUENCE 473 AA; 52580 MW; 9DCB04B2A0AB1132 CRC64;
MGAVLGVFSL ASWVPCLCSG ASCLLCSCCP NSKNSTVTRL IYAFILLLST VVSYIMQRKE
METYLKKIPG FCEGGFKIHE ADINADKDCD VLVGYKAVYR ISFAMAIFFF VFSLLMFKVK
TSKDLRAAVH NGFWFFKIAA LIGIMVGSFY IPGGYFSSVW FVVGMIGAAL FILIQLVLLV
DFAHSWNESW VNRMEEGNPR LWYAALLSFT SAFYILSIIC VGLLYTYYTK PDGCTENKFF
ISINLILCVV ASIISIHPKI QEHQPRSGLL QSSLITLYTM YLTWSAMSNE PDRSCNPNLM
SFITRITAPT LAPGNSTAVV PTPTPPSKSG SLLDSDNFIG LFVFVLCLLY SSIRTSTNSQ
VDKLTLSGSD SVILGDTTTS GASDEEDGQP RRAVDNEKEG VQYSYSLFHL MLCLASLYIM
MTLTSWYSPD AKFQSMTSKW PAVWVKISSS WVCLLLYVWT LVAPLVLTSR DFS
