SERC4_MOUSE
ID SERC4_MOUSE Reviewed; 492 AA.
AC Q5XK03; Q8C8U1;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Serine incorporator 4;
GN Name=Serinc4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Incorporates a polar amino acid serine into membranes and
CC facilitates the synthesis of two serine-derived lipids,
CC phosphatidylserine and sphingolipids. {ECO:0000250|UniProtKB:A6NH21}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TDE1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC31945.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK044479; BAC31945.1; ALT_FRAME; mRNA.
DR EMBL; AL845466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC083132; AAH83132.1; -; mRNA.
DR CCDS; CCDS16646.1; -.
DR RefSeq; NP_001020542.1; NM_001025371.2.
DR AlphaFoldDB; Q5XK03; -.
DR SMR; Q5XK03; -.
DR STRING; 10090.ENSMUSP00000051261; -.
DR PhosphoSitePlus; Q5XK03; -.
DR PaxDb; Q5XK03; -.
DR PRIDE; Q5XK03; -.
DR Antibodypedia; 11477; 54 antibodies from 16 providers.
DR Ensembl; ENSMUST00000056312; ENSMUSP00000051261; ENSMUSG00000046110.
DR GeneID; 574418; -.
DR KEGG; mmu:574418; -.
DR UCSC; uc008lze.1; mouse.
DR CTD; 619189; -.
DR MGI; MGI:2441842; Serinc4.
DR VEuPathDB; HostDB:ENSMUSG00000046110; -.
DR eggNOG; KOG2592; Eukaryota.
DR GeneTree; ENSGT01030000234623; -.
DR HOGENOM; CLU_029574_5_2_1; -.
DR InParanoid; Q5XK03; -.
DR OMA; IHNFWFL; -.
DR OrthoDB; 1276632at2759; -.
DR PhylomeDB; Q5XK03; -.
DR TreeFam; TF312881; -.
DR Reactome; R-MMU-977347; Serine biosynthesis.
DR BioGRID-ORCS; 574418; 2 hits in 40 CRISPR screens.
DR PRO; PR:Q5XK03; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q5XK03; protein.
DR Bgee; ENSMUSG00000046110; Expressed in retinal neural layer and 68 other tissues.
DR ExpressionAtlas; Q5XK03; baseline and differential.
DR Genevisible; Q5XK03; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR InterPro; IPR029563; Serinc4.
DR InterPro; IPR005016; TDE1/TMS.
DR PANTHER; PTHR10383; PTHR10383; 1.
DR PANTHER; PTHR10383:SF5; PTHR10383:SF5; 1.
DR Pfam; PF03348; Serinc; 1.
PE 2: Evidence at transcript level;
KW Lipid biosynthesis; Lipid metabolism; Membrane; Phospholipid biosynthesis;
KW Phospholipid metabolism; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..492
FT /note="Serine incorporator 4"
FT /id="PRO_0000333872"
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 219..239
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 464..484
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 53
FT /note="R -> T (in Ref. 1; BAC31945)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="S -> P (in Ref. 1; BAC31945)"
FT /evidence="ECO:0000305"
FT CONFLICT 217
FT /note="L -> F (in Ref. 1; BAC31945)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 492 AA; 53907 MW; 7EF5BDAB070D2646 CRC64;
MMGAKVVTGR STTQGLAQQH GGVSNVVETP FNQASCCGPV SWTSGCHSLT ESRCSRLLYI
LLHVGASAIC CLLLSKTVVE RVWGKAHGIQ MPSVLCAHLF GSSDCPVLSG SGAVYRVCAG
TATFHLLQAV LLVRLHSPTN PRAQLHNSFW SLKLLFLLGL CVVAFCIPDE DLFPAWHYIG
ICGGFTFILL QLVLITAFAQ SWNKNWQTGA AQDCSWLLGV SLATLGFYSM AGVGAVLLFH
QYTHPDGCLL NKMLLSLHLC FCGLLSLLSI APCIRRKQPN SGLLQASIIS CYIMYLTFSA
LSSRPPETIT FQGQNHTLCL PGRNKMEPQI PDTSVAVFSA GIMYACVLFA CNEASYLAEL
FGPLWIIKVY KYEFQKPSVC FCCPQTVEPE DGQRSRARSA DQETPPAAQV QSQHLSYSYS
GFHFAFFLAS LYVMVTLTNW FSYEEAELEK TFTKGSWATF WVKVASCWAC VLLYLGLLLA
PLLAPHSESP PP
