ID   SERF1_BOVIN             Reviewed;          62 AA.
AC   Q32P76;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Small EDRK-rich factor 1;
GN   Name=SERF1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positive regulator of amyloid protein aggregation and
CC       proteotoxicity (By similarity). Induces conformational changes in
CC       amyloid proteins, such as APP, HTT, and SNCA, driving them into compact
CC       formations preceding the formation of aggregates (By similarity).
CC       {ECO:0000250|UniProtKB:O75920}.
CC   -!- SUBUNIT: Interacts with SNCA; this interaction promotes the aggregation
CC       of SNCA. {ECO:0000250|UniProtKB:O75920}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:Q9BKU8}. Nucleus {ECO:0000250|UniProtKB:Q9BKU8}.
CC   -!- SIMILARITY: Belongs to the SERF family. {ECO:0000305}.
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DR   EMBL; BC108230; AAI08231.1; -; mRNA.
DR   RefSeq; NP_001106772.1; NM_001113301.1.
DR   AlphaFoldDB; Q32P76; -.
DR   STRING; 9913.ENSBTAP00000045674; -.
DR   PaxDb; Q32P76; -.
DR   GeneID; 526395; -.
DR   KEGG; bta:526395; -.
DR   CTD; 8293; -.
DR   eggNOG; KOG4488; Eukaryota.
DR   HOGENOM; CLU_165034_1_1_1; -.
DR   InParanoid; Q32P76; -.
DR   OrthoDB; 1641955at2759; -.
DR   TreeFam; TF330718; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR040211; SERF1/2.
DR   InterPro; IPR007513; Uncharacterised_SERF_N.
DR   PANTHER; PTHR13596; PTHR13596; 1.
DR   Pfam; PF04419; 4F5; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..62
FT                   /note="Small EDRK-rich factor 1"
FT                   /id="PRO_0000268194"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   62 AA;  7379 MW;  AD75CC1B0AF5D53E CRC64;
     MARGNQRELA RQKNMKKSQE ISKGKRKEDS LTTSQRKQRD SEIMQQKQKA ANERKSMQTR
     EK