ID   SERF1_MOUSE             Reviewed;          62 AA.
AC   O88892;
DT   19-SEP-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Small EDRK-rich factor 1;
DE   AltName: Full=Protein 4F5;
DE            Short=m4F5;
GN   Name=Serf1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=C57BL/6J;
RX   PubMed=9731538; DOI=10.1038/1753;
RA   Scharf J.M., Endrizzi M.G., Wetter A., Huang S., Thompson T.G., Zerres K.,
RA   Dietrich W.F., Wirth B., Kunkel L.M.;
RT   "Identification of a candidate modifying gene for spinal muscular atrophy
RT   by comparative genomics.";
RL   Nat. Genet. 20:83-86(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/Sv;
RX   PubMed=10486205; DOI=10.1006/geno.1999.5910;
RA   Endrizzi M., Huang S., Scharf J.M., Kelter A.R., Wirth B., Kunkel L.M.,
RA   Miller W., Dietrich W.F.;
RT   "Comparative sequence analysis of the mouse and human Lgn1/SMA interval.";
RL   Genomics 60:137-151(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   INTERACTION WITH SNCA, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=31034892; DOI=10.1016/j.jmb.2019.04.031;
RA   Merle D.A., Witternigg A., Tam-Amersdorfer C., Hartlmueller C.,
RA   Spreitzer E., Schrank E., Wagner-Lichtenegger S., Werzer O., Zangger K.,
RA   Kungl A.J., Madl T., Meyer N.H., Falsone S.F.;
RT   "Increased Aggregation Tendency of Alpha-Synuclein in a Fully Disordered
RT   Protein Complex.";
RL   J. Mol. Biol. 431:2581-2598(2019).
CC   -!- FUNCTION: Positive regulator of amyloid protein aggregation and
CC       proteotoxicity (By similarity). Induces conformational changes in
CC       amyloid proteins, such as APP, HTT, and SNCA, driving them into compact
CC       formations preceding the formation of aggregates (By similarity).
CC       {ECO:0000250|UniProtKB:O75920}.
CC   -!- SUBUNIT: Interacts with SNCA; this interaction promotes the aggregation
CC       of SNCA. {ECO:0000269|PubMed:31034892}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:31034892}.
CC       Nucleus {ECO:0000250|UniProtKB:O75920}.
CC   -!- TISSUE SPECIFICITY: Expressed in brain (at protein level)
CC       (PubMed:31034892). Highly expressed in the testis (PubMed:9731538).
CC       {ECO:0000269|PubMed:31034892, ECO:0000269|PubMed:9731538}.
CC   -!- SIMILARITY: Belongs to the SERF family. {ECO:0000305}.
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DR   EMBL; AF073517; AAC63514.1; -; mRNA.
DR   EMBL; AF131205; AAD56758.1; -; Genomic_DNA.
DR   EMBL; BC028510; AAH28510.1; -; mRNA.
DR   CCDS; CCDS36765.1; -.
DR   RefSeq; NP_035483.1; NM_011353.2.
DR   AlphaFoldDB; O88892; -.
DR   STRING; 10090.ENSMUSP00000022145; -.
DR   iPTMnet; O88892; -.
DR   PhosphoSitePlus; O88892; -.
DR   MaxQB; O88892; -.
DR   PaxDb; O88892; -.
DR   PRIDE; O88892; -.
DR   DNASU; 20365; -.
DR   Ensembl; ENSMUST00000022145; ENSMUSP00000022145; ENSMUSG00000021643.
DR   Ensembl; ENSMUST00000129014; ENSMUSP00000121421; ENSMUSG00000021643.
DR   GeneID; 20365; -.
DR   KEGG; mmu:20365; -.
DR   UCSC; uc007rqf.2; mouse.
DR   CTD; 20365; -.
DR   MGI; MGI:1337114; Serf1.
DR   VEuPathDB; HostDB:ENSMUSG00000021643; -.
DR   eggNOG; KOG4488; Eukaryota.
DR   GeneTree; ENSGT00940000161793; -.
DR   HOGENOM; CLU_165034_1_1_1; -.
DR   InParanoid; O88892; -.
DR   OMA; KKDGDPK; -.
DR   OrthoDB; 1641955at2759; -.
DR   PhylomeDB; O88892; -.
DR   TreeFam; TF330718; -.
DR   BioGRID-ORCS; 20365; 0 hits in 69 CRISPR screens.
DR   ChiTaRS; Serf1; mouse.
DR   PRO; PR:O88892; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; O88892; protein.
DR   Bgee; ENSMUSG00000021643; Expressed in embryonic brain and 252 other tissues.
DR   ExpressionAtlas; O88892; baseline and differential.
DR   Genevisible; O88892; MM.
DR   GO; GO:0005829; C:cytosol; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; ISO:MGI.
DR   GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR   GO; GO:1990000; P:amyloid fibril formation; IEA:Ensembl.
DR   GO; GO:0031648; P:protein destabilization; IEA:Ensembl.
DR   InterPro; IPR040211; SERF1/2.
DR   InterPro; IPR007513; Uncharacterised_SERF_N.
DR   PANTHER; PTHR13596; PTHR13596; 1.
DR   Pfam; PF04419; 4F5; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..62
FT                   /note="Small EDRK-rich factor 1"
FT                   /id="PRO_0000050711"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..62
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   62 AA;  7322 MW;  174DC9BB067982A6 CRC64;
     MARGNQREIA RQKNMKKTQE ISKGKRKEDS LTASQRKQRD SEIMQQKQKI ANEKKSMQTT
     EK