SERF2_MOUSE
ID SERF2_MOUSE Reviewed; 59 AA.
AC P84102; A2ARQ3; O75918; O88891; Q9BZH7;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Small EDRK-rich factor 2;
DE AltName: Full=Protein 4F5-related;
DE Short=4F5rel;
GN Name=Serf2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9731538; DOI=10.1038/1753;
RA Scharf J.M., Endrizzi M.G., Wetter A., Huang S., Thompson T.G., Zerres K.,
RA Dietrich W.F., Wirth B., Kunkel L.M.;
RT "Identification of a candidate modifying gene for spinal muscular atrophy
RT by comparative genomics.";
RL Nat. Genet. 20:83-86(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Embryonic stem cell, Kidney, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Pancreas;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Positive regulator of amyloid protein aggregation and
CC proteotoxicity (By similarity). Induces conformational changes in
CC amyloid proteins, such as HTT, driving them into compact formations
CC preceding the formation of aggregates (By similarity).
CC {ECO:0000250|UniProtKB:P84101}.
CC -!- SIMILARITY: Belongs to the SERF family. {ECO:0000305}.
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DR EMBL; AF073297; AAC63515.1; -; mRNA.
DR EMBL; AK002351; BAB22030.3; -; mRNA.
DR EMBL; AK008802; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK010749; BAB27157.1; -; mRNA.
DR EMBL; AK012395; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK012603; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK018746; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AL845466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS16645.1; -.
DR RefSeq; NP_035484.1; NM_011354.3.
DR AlphaFoldDB; P84102; -.
DR BioGRID; 237553; 1.
DR STRING; 10090.ENSMUSP00000123181; -.
DR iPTMnet; P84102; -.
DR PhosphoSitePlus; P84102; -.
DR EPD; P84102; -.
DR MaxQB; P84102; -.
DR PaxDb; P84102; -.
DR PeptideAtlas; P84102; -.
DR PRIDE; P84102; -.
DR ProteomicsDB; 256622; -.
DR TopDownProteomics; P84102; -.
DR Antibodypedia; 34934; 77 antibodies from 17 providers.
DR Ensembl; ENSMUST00000139253; ENSMUSP00000123181; ENSMUSG00000074884.
DR GeneID; 378702; -.
DR KEGG; mmu:378702; -.
DR UCSC; uc008lzd.2; mouse.
DR CTD; 10169; -.
DR MGI; MGI:1337041; Serf2.
DR VEuPathDB; HostDB:ENSMUSG00000074884; -.
DR eggNOG; KOG4488; Eukaryota.
DR GeneTree; ENSGT00910000144347; -.
DR HOGENOM; CLU_165034_1_1_1; -.
DR InParanoid; P84102; -.
DR OMA; QRDADIM; -.
DR TreeFam; TF330718; -.
DR BioGRID-ORCS; 378702; 4 hits in 71 CRISPR screens.
DR ChiTaRS; Serf2; mouse.
DR PRO; PR:P84102; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P84102; protein.
DR Bgee; ENSMUSG00000074884; Expressed in white adipose tissue and 64 other tissues.
DR ExpressionAtlas; P84102; baseline and differential.
DR Genevisible; P84102; MM.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0031648; P:protein destabilization; ISO:MGI.
DR InterPro; IPR040211; SERF1/2.
DR InterPro; IPR007513; Uncharacterised_SERF_N.
DR PANTHER; PTHR13596; PTHR13596; 1.
DR Pfam; PF04419; 4F5; 1.
PE 1: Evidence at protein level;
KW Reference proteome.
FT CHAIN 1..59
FT /note="Small EDRK-rich factor 2"
FT /id="PRO_0000050713"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 59 AA; 6900 MW; 24FB33BF94FFFAE4 CRC64;
MTRGNQRELA RQKNMKKQSD SVKGKRRDDG LSAAARKQRD SEIMQQKQKK ANEKKEEPK
