SERF2_PLEMO
ID SERF2_PLEMO Reviewed; 59 AA.
AC B1MTI8;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 20.
DE RecName: Full=Small EDRK-rich factor 2;
GN Name=SERF2;
OS Plecturocebus moloch (Dusky titi monkey) (Callicebus moloch).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini;
OC Pitheciidae; Callicebinae; Plecturocebus.
OX NCBI_TaxID=9523;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C.,
RA Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M.,
RA Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N.,
RA Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B.,
RA Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R.,
RA Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C.,
RA Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C.,
RA Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K.,
RA Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J.,
RA Tsipouri V., Young A., Green E.D.;
RT "NISC comparative sequencing initiative.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Positive regulator of amyloid protein aggregation and
CC proteotoxicity (By similarity). Induces conformational changes in
CC amyloid proteins, such as HTT, driving them into compact formations
CC preceding the formation of aggregates (By similarity).
CC {ECO:0000250|UniProtKB:P84101}.
CC -!- SIMILARITY: Belongs to the SERF family. {ECO:0000305}.
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DR EMBL; DP000636; ACA57912.1; -; Genomic_DNA.
DR AlphaFoldDB; B1MTI8; -.
DR InterPro; IPR040211; SERF1/2.
DR InterPro; IPR007513; Uncharacterised_SERF_N.
DR PANTHER; PTHR13596; PTHR13596; 1.
DR Pfam; PF04419; 4F5; 1.
PE 3: Inferred from homology;
FT CHAIN 1..59
FT /note="Small EDRK-rich factor 2"
FT /id="PRO_0000357056"
FT REGION 1..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 59 AA; 6900 MW; 24FB33BF94FFFAE4 CRC64;
MTRGNQRELA RQKNMKKQSD SVKGKRRDDG LSAAARKQRD SEIMQQKQKK ANEKKEEPK