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SERHL_DANRE
ID   SERHL_DANRE             Reviewed;         326 AA.
AC   A2BGU9; Q6NYD3; Q803G4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Serine hydrolase-like protein;
DE            EC=3.1.-.-;
GN   Name=serhl; ORFNames=ch211-214c7.1, zgc:55804;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable serine hydrolase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH44494.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAH66637.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; BX511120; CAM14020.1; -; Genomic_DNA.
DR   EMBL; BC044494; AAH44494.1; ALT_INIT; mRNA.
DR   EMBL; BC066637; AAH66637.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_955909.2; NM_199615.2.
DR   AlphaFoldDB; A2BGU9; -.
DR   SMR; A2BGU9; -.
DR   STRING; 7955.ENSDARP00000042157; -.
DR   ESTHER; danre-A2BGU9; SERHL.
DR   MEROPS; S33.B18; -.
DR   PaxDb; A2BGU9; -.
DR   PeptideAtlas; A2BGU9; -.
DR   Ensembl; ENSDART00000042158; ENSDARP00000042157; ENSDARG00000032340.
DR   GeneID; 322648; -.
DR   KEGG; dre:322648; -.
DR   CTD; 94009; -.
DR   ZFIN; ZDB-GENE-030131-1368; serhl.
DR   eggNOG; KOG1454; Eukaryota.
DR   GeneTree; ENSGT00530000063960; -.
DR   HOGENOM; CLU_020336_8_2_1; -.
DR   InParanoid; A2BGU9; -.
DR   OMA; RGLMPVP; -.
DR   OrthoDB; 1285824at2759; -.
DR   PhylomeDB; A2BGU9; -.
DR   TreeFam; TF326547; -.
DR   PRO; PR:A2BGU9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 1.
DR   Bgee; ENSDARG00000032340; Expressed in cardiac ventricle and 24 other tissues.
DR   GO; GO:0016787; F:hydrolase activity; IBA:GO_Central.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   PRINTS; PR00111; ABHYDROLASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..326
FT                   /note="Serine hydrolase-like protein"
FT                   /id="PRO_0000369253"
FT   DOMAIN          44..155
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        118
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   326 AA;  37106 MW;  C4641D7A578E2A29 CRC64;
     MLPAFMSLRH FTTTTMRRAA SEFRMPVPWG ELRGQVWGPS HGRPVLCLHG WADNSGTFNT
     LVPLLPNDWR FVAIDFPGHG LSSHRPDGCF YAFPFYVADV RRVVEALQWK RFSIIGHSMG
     GNVAGMFSAL YPEMVESVVL LDTYGFLPTE VTDMFTNMRK GINDQIQYDN MANERKERVY
     TYEKAKERLK VANPYLSDQS ADILLERAVR EVDGGFVFTR DFRINLKNII YINIDQCLHV
     LSQVKAKVML LLAKDGLFKT FTLPDGYADR ICKSWTDQKA TFVEVEGDHH VHLNNPEAVS
     SVITDFLQPQ SPDQTESQSG NQTSRL
 
 
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