ID   SERIC_DICDI             Reviewed;         417 AA.
AC   Q54UF8;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Probable serine incorporator;
GN   Name=serinc; ORFNames=DDB_G0281099;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Enhances the incorporation of serine into phosphatidylserine
CC       and sphingolipids. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TDE1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000040; EAL66846.1; -; Genomic_DNA.
DR   RefSeq; XP_640818.1; XM_635726.1.
DR   AlphaFoldDB; Q54UF8; -.
DR   SMR; Q54UF8; -.
DR   STRING; 44689.DDB0238344; -.
DR   PaxDb; Q54UF8; -.
DR   EnsemblProtists; EAL66846; EAL66846; DDB_G0281099.
DR   GeneID; 8622872; -.
DR   KEGG; ddi:DDB_G0281099; -.
DR   dictyBase; DDB_G0281099; -.
DR   eggNOG; KOG2592; Eukaryota.
DR   HOGENOM; CLU_029574_5_0_1; -.
DR   InParanoid; Q54UF8; -.
DR   OMA; MEPDDKQ; -.
DR   PhylomeDB; Q54UF8; -.
DR   Reactome; R-DDI-977347; Serine biosynthesis.
DR   PRO; PR:Q54UF8; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005016; TDE1/TMS.
DR   InterPro; IPR029559; Tms1-like.
DR   PANTHER; PTHR10383; PTHR10383; 1.
DR   PANTHER; PTHR10383:SF9; PTHR10383:SF9; 1.
DR   Pfam; PF03348; Serinc; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..417
FT                   /note="Probable serine incorporator"
FT                   /id="PRO_0000342155"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        339..359
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        391..411
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   417 AA;  46200 MW;  3CF0E13342206296 CRC64;
     MQSFMTGAPG HHIQSIKKST STRLVYVVFF LLVSIVAYIL SYWTFSWFNN LDVLKICSKG
     DNECKGALVV YRLTFGLALY HILLGLVMIN VKSAGDSRAK LQDGYWPLKI LLLGVLIFVS
     FFIPNSFFRV YTWISIFSAA IFIFIQLVLL IECAYSLNES CVRKIEDEGH SGKKWYVLLC
     VLSFGSIALA VAGTVLMLVF YGRGSCSINQ FYIVFNLGIC LIVGVLSISE KVREYRPSSG
     LFQSGVVMLY CTYLIYSAIN SEPPGTCSSN NTSSPKESTI IIGAVFTIIS VCYSAFRSSD
     STELLGNHNH YSSIPTDPNA ETTGVADDEC ECTAYNYSFF HFTFACGAMY LSALLTNWAT
     MTSTDITSSS TSSSNSTISV DSGMVSVWVK VVSSWVVVLL YLWTLIGPIL LRNRVWD