ID   SERIC_MONBE             Reviewed;         483 AA.
AC   A9UY97;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Probable serine incorporator;
GN   Name=serinc; ORFNames=18904;
OS   Monosiga brevicollis (Choanoflagellate).
OC   Eukaryota; Choanoflagellata; Craspedida; Salpingoecidae; Monosiga.
OX   NCBI_TaxID=81824;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MX1 / ATCC 50154;
RX   PubMed=18273011; DOI=10.1038/nature06617;
RG   JGI Sequencing;
RA   King N., Westbrook M.J., Young S.L., Kuo A., Abedin M., Chapman J.,
RA   Fairclough S., Hellsten U., Isogai Y., Letunic I., Marr M., Pincus D.,
RA   Putnam N., Rokas A., Wright K.J., Zuzow R., Dirks W., Good M.,
RA   Goodstein D., Lemons D., Li W., Lyons J.B., Morris A., Nichols S.,
RA   Richter D.J., Salamov A., Bork P., Lim W.A., Manning G., Miller W.T.,
RA   McGinnis W., Shapiro H., Tjian R., Grigoriev I.V., Rokhsar D.;
RT   "The genome of the choanoflagellate Monosiga brevicollis and the origin of
RT   metazoans.";
RL   Nature 451:783-788(2008).
CC   -!- FUNCTION: Enhances the incorporation of serine into phosphatidylserine
CC       and sphingolipids. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TDE1 family. {ECO:0000305}.
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DR   EMBL; CH991549; EDQ89821.1; -; Genomic_DNA.
DR   RefSeq; XP_001745243.1; XM_001745191.1.
DR   AlphaFoldDB; A9UY97; -.
DR   SMR; A9UY97; -.
DR   STRING; 81824.XP_001745243.1; -.
DR   EnsemblProtists; EDQ89821; EDQ89821; MONBRDRAFT_18904.
DR   GeneID; 5890460; -.
DR   KEGG; mbr:MONBRDRAFT_18904; -.
DR   eggNOG; KOG2592; Eukaryota.
DR   InParanoid; A9UY97; -.
DR   OMA; MEPDDKQ; -.
DR   Proteomes; UP000001357; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005016; TDE1/TMS.
DR   InterPro; IPR029559; Tms1-like.
DR   PANTHER; PTHR10383; PTHR10383; 1.
DR   PANTHER; PTHR10383:SF9; PTHR10383:SF9; 1.
DR   Pfam; PF03348; Serinc; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..483
FT                   /note="Probable serine incorporator"
FT                   /id="PRO_0000342156"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        414..434
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   483 AA;  52665 MW;  51196206B5806C33 CRC64;
     MGLVASCFGG LAAYAAESVA CCCGSAACSL CCRSCPSCTN STSTRITYAI LFFLSSIAAW
     IMLDKDVSKG LMKVCCYHST LFRLVLFTQP AIKTTTNVVP WGELGVMRIM FSVCLFHLFL
     SLCTIGVSSS KDPRSSLHNG MWFIKLILLV GAMVGSFFIS NSFFIGASWS WIGLVGAVLF
     MIVQFILLVD FAYSWNDSWV GKLEEGSKCA GFGSYRLISA TVMLMAFVIT LTVLMFHFYT
     NGDCKLSNFF IGFNLALALL VTLTSMLPSV REALPSSGIL QSSVVAAYAT YLVWSAVSGV
     PSTCHPLIAV APLFLSSRGF LPPLPYVALK PAECGGDAGT NTAAIVIGAL LTFISVAYSS
     IRTSSKSQLG KLGLQQGSNE NIYLMDDKAA DFDEDDEDRR LQRVVDNEQD AVRYSWSFFH
     LTFAVAALYL MMVLTEWDSS DADVRIGKGW ASVWVQVVSS WVIFLLYGWT MMAPVCLPDR
     DFS