ID   SERIC_NEMVE             Reviewed;         456 AA.
AC   A7S4N4;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Probable serine incorporator;
GN   Name=serinc; ORFNames=v1g242820;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Enhances the incorporation of serine into phosphatidylserine
CC       and sphingolipids. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TDE1 family. {ECO:0000305}.
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DR   EMBL; DS469579; EDO41353.1; -; Genomic_DNA.
DR   RefSeq; XP_001633416.1; XM_001633366.1.
DR   AlphaFoldDB; A7S4N4; -.
DR   SMR; A7S4N4; -.
DR   EnsemblMetazoa; EDO41353; EDO41353; NEMVEDRAFT_v1g242820.
DR   GeneID; 5513123; -.
DR   KEGG; nve:5513123; -.
DR   eggNOG; KOG2592; Eukaryota.
DR   HOGENOM; CLU_029574_5_0_1; -.
DR   InParanoid; A7S4N4; -.
DR   OMA; VRILTAW; -.
DR   OrthoDB; 1276632at2759; -.
DR   PhylomeDB; A7S4N4; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0006658; P:phosphatidylserine metabolic process; IEA:InterPro.
DR   GO; GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR   InterPro; IPR029557; Serinc1/3.
DR   InterPro; IPR005016; TDE1/TMS.
DR   PANTHER; PTHR10383; PTHR10383; 2.
DR   PANTHER; PTHR10383:SF51; PTHR10383:SF51; 2.
DR   Pfam; PF03348; Serinc; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Lipid biosynthesis; Lipid metabolism; Membrane;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..456
FT                   /note="Probable serine incorporator"
FT                   /id="PRO_0000342157"
FT   TRANSMEM        10..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        95..115
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        301..321
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        430..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   456 AA;  50341 MW;  9C3001AE47B1A2B8 CRC64;
     MGAVLGACTA ASCAANLACC CGSAACSLCC NFCPTCKNST STRIVYSIFL LFGLVVSCIV
     LAPGIRHKLN QIPYLCEHAS ETCDSIVGYL AVYRVCFGLA AFFLLFCLLM YGVTSSRDVR
     SKIQNGFWGI KILLFLGAIV AAFFIPQGKF SEVWMYFGLI GSFLFILIQL VLLVDFAHTW
     NSSWVGRMEE SGSKVWAVLL LCATFLMYGF CVAGIVCLYV YFTYSQESSC HTNKFFISFN
     LILCIIASVL AIHPKVQERL PTSGLLQASV ISLYTVYLTW SALSFQPDKN CNGFYETHIT
     LAGMDSQAII GVILMFVMVV YASVRTASSS QVGKLGMSSP KHSSALDKET TVLSEGDETR
     SDVGLVEEGG EGRRVYDDED GGVAYSYSFY HFMLMLASLY IMMTLTNWYK PVGSDFSKLQ
     YSETAVWVKI ASSWLCQLIY IWTLLAPALF PDRDFS