ID   SERP1_BOVIN             Reviewed;          66 AA.
AC   Q3ZBR1;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Stress-associated endoplasmic reticulum protein 1;
DE   AltName: Full=Ribosome-attached membrane protein 4;
GN   Name=SERP1; Synonyms=RAMP4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Interacts with target proteins during their translocation
CC       into the lumen of the endoplasmic reticulum. Protects unfolded target
CC       proteins against degradation during ER stress. May facilitate
CC       glycosylation of target proteins after termination of ER stress. May
CC       modulate the use of N-glycosylation sites on target proteins (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SEC61B, SEC61A1 and the SEC61 complex.
CC       Interacts with CANX (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein.
CC       Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RAMP4 family. {ECO:0000305}.
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DR   EMBL; BC103162; AAI03163.1; -; mRNA.
DR   RefSeq; NP_001107555.1; NM_001114083.2.
DR   AlphaFoldDB; Q3ZBR1; -.
DR   SMR; Q3ZBR1; -.
DR   STRING; 9913.ENSBTAP00000012000; -.
DR   PaxDb; Q3ZBR1; -.
DR   Ensembl; ENSBTAT00000012000; ENSBTAP00000012000; ENSBTAG00000009104.
DR   GeneID; 528100; -.
DR   KEGG; bta:528100; -.
DR   CTD; 27230; -.
DR   VEuPathDB; HostDB:ENSBTAG00000009104; -.
DR   VGNC; VGNC:34464; SERP1.
DR   eggNOG; KOG3491; Eukaryota.
DR   GeneTree; ENSGT00940000161729; -.
DR   HOGENOM; CLU_160944_3_0_1; -.
DR   InParanoid; Q3ZBR1; -.
DR   OMA; TSQWLIG; -.
DR   OrthoDB; 1605112at2759; -.
DR   TreeFam; TF313229; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000009104; Expressed in saliva-secreting gland and 107 other tissues.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IBA:GO_Central.
DR   GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
DR   GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR   GO; GO:0010259; P:multicellular organism aging; IEA:Ensembl.
DR   GO; GO:0048644; P:muscle organ morphogenesis; IEA:Ensembl.
DR   GO; GO:0060124; P:positive regulation of growth hormone secretion; IEA:Ensembl.
DR   GO; GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0046622; P:positive regulation of organ growth; IEA:Ensembl.
DR   GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0006486; P:protein glycosylation; IBA:GO_Central.
DR   GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR   InterPro; IPR010580; ER_stress-assoc.
DR   PANTHER; PTHR15601; PTHR15601; 1.
DR   Pfam; PF06624; RAMP4; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..66
FT                   /note="Stress-associated endoplasmic reticulum protein 1"
FT                   /id="PRO_0000274793"
FT   TOPO_DOM        1..38
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..66
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   66 AA;  7374 MW;  DC15C0143AAE0D91 CRC64;
     MVAKQRIRMA NEKHSKNITQ RGNVAKTSRN APEEKASVGP WLLALFIFVV CGSAIFQIIQ
     SIRMGM