ID   SERP1_PONAB             Reviewed;          66 AA.
AC   Q5REZ1;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Stress-associated endoplasmic reticulum protein 1;
DE   AltName: Full=Ribosome-attached membrane protein 4;
GN   Name=SERP1; Synonyms=RAMP4;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Interacts with target proteins during their translocation
CC       into the lumen of the endoplasmic reticulum. Protects unfolded target
CC       proteins against degradation during ER stress. May facilitate
CC       glycosylation of target proteins after termination of ER stress. May
CC       modulate the use of N-glycosylation sites on target proteins (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SEC61B, SEC61A1 and the SEC61 complex.
CC       Interacts with CANX (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane protein.
CC       Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane
CC       protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RAMP4 family. {ECO:0000305}.
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DR   EMBL; CR857372; CAH89666.1; -; mRNA.
DR   RefSeq; NP_001124752.1; NM_001131280.1.
DR   AlphaFoldDB; Q5REZ1; -.
DR   SMR; Q5REZ1; -.
DR   STRING; 9601.ENSPPYP00000015887; -.
DR   GeneID; 100171602; -.
DR   KEGG; pon:100171602; -.
DR   CTD; 27230; -.
DR   eggNOG; KOG3491; Eukaryota.
DR   InParanoid; Q5REZ1; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010580; ER_stress-assoc.
DR   PANTHER; PTHR15601; PTHR15601; 1.
DR   Pfam; PF06624; RAMP4; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Protein transport; Reference proteome;
KW   Translocation; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..66
FT                   /note="Stress-associated endoplasmic reticulum protein 1"
FT                   /id="PRO_0000274796"
FT   TOPO_DOM        1..38
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        60..66
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   66 AA;  7302 MW;  DC1696215AAE0D91 CRC64;
     MVAKQRIRMA NEKHSKNITQ RGNVAKTSRN APGEKASVGP WLLALFIFVV CGSAIFQIIQ
     SIRMGM